Dermal Cell News Volume 6.06 | Feb 24 2020

TOP STORY

Stroma Remodeling and Reduced Cell Division Define Durable Response to PD-1 Blockade in Melanoma

Researchers showed the genetic and phenotypic changes induced by treatment with programmed cell death-1 (PD-1) blockade in a genetically engineered mouse model of melanoma driven by oncogenic BRAF. [Nat Commun] Full Article

(Ranked by impact factor of the journal)

DERMAL STEM CELLS & TISSUE REGENERATION

Inhibition of Keratinocyte Necroptosis Mediated by RIPK1/RIPK3/MLKL Provides a Protective Effect against Psoriatic Inflammation

The authors provide evidence for the involvement of necroptosis in psoriasis. Receptor interacting protein kinase 1 (RIPK1) and mixed lineage kinase domain-like pseudokinase (MLKL) were significantly upregulated and localized in all layers of the epidermis in human psoriatic lesions, while RIPK3 and phosphorylated MLKL were mainly expressed in keratinocytes, which is located in the upper layers. [Cell Death Dis] Full Article

UVB-Dependent Inhibition of Lipin-1 Protects against Proinflammatory Responses in Human Keratinocytes

The function of lipin-1 in UVB-induced proinflammatory responses was assessed in normal human epidermal keratinocytes. UVB radiation downregulated lipin-1 expression. [Exp Mol Med] Full Article

A TGF-β- and p63-Responsive Enhancer Regulates IFN-κ Expression in Human Keratinocytes

Researchers identified an enhancer ~5 kb upstream of the IFNK gene driving its expression in keratinocytes. The enhancer consisted of binding sites for the transcription factors jun-B, SMAD3/4, AP-2α/γ, and p63, of which the latter two are key regulators of keratinocyte biology. [J Immunol] Abstract

3D Printing of Silver-Doped Polycaprolactone-Poly Propylene Succinate Composite Scaffolds for Skin Tissue Engineering

The cell viability and the cytotoxicity of a developed copolymer were evaluated by using human dermal fibroblast (HDF) cells. The addition of silver nitrate within the polymer matrix resulted in a significant decrease in the adhesion of different types of microorganisms on the scaffold without inducing any cytotoxicity on HDF cells in vitro. [Biomed Mater] Abstract

Auto Micro Atomization Delivery of Human Epidermal Organoids Improves Therapeutic Effects for Skin Wound Healing

Investigators showed the improved effects of cell transplantation therapy using a robust protocol of efficient expansion and delivery of epidermal cells for treatment of severe skin wounds. Human skin tissues were used to generate human epidermal organoids maintained under newly established culture conditions. [Front Bioeng Biotechnol] Full Article

SKIN CANCERS & DISORDERS

T-Type Calcium Channel Inhibition Restores Sensitivity to MAPK Inhibitors in De-Differentiated and Adaptive Melanoma Cells

Scientists investigated the melanoma phenotype switching using a partial reprogramming model to de-differentiate murine melanoma cells and target melanoma therapy adaptation against mitogen-activated protein kinase inhibitors. [Br J Cancer] Full Article

A Targeted Quantitative Proteomic Method Revealed a Substantial Reprogramming of Kinome during Melanoma Metastasis

The authors applied a parallel-reaction monitoring-based targeted proteomic method to assess kinome reprogramming during melanoma metastasis in three pairs of matched primary/metastatic human melanoma cell lines. [Sci Rep] Full Article

A Rare Subpopulation of Melanoma Cells with Low Expression of Metastasis Suppressor NME1 Is Highly Metastatic In Vivo

Investigators identified a rare subpopulation of cells with markedly reduced expression of NME1 in human melanoma cell lines. [Sci Rep] Full Article

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miRNAs as Key Players in the Management of Cutaneous Melanoma

The authors provide an overview of current scientific knowledge regarding the oncogenic or oncosuppressive role of miRNAs in melanoma and their use as biomarkers, with respect to approved therapies for melanoma treatment. [Cells] Abstract | Graphical Abstract | Download Full Article

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Arcutis Announces Enrollment of First Patient in Topical Roflumilast Cream Phase III Open Label Extension Study in Plaque Psoriasis

Arcutis Biotherapeutics, Inc. announced it has enrolled the first patient in an open label extension study, DERMIS-OLE, evaluating topical roflumilast cream as a potential treatment for plaque psoriasis. [Arcutis Biotherapeutics, Inc.] Press Release

Incyte Announces Positive Topline Results from Phase III TRuE-AD Program Evaluating Ruxolitinib Cream in Patients with Atopic Dermatitis

Incyte announced that the second randomized, vehicle-controlled, pivotal Phase III study from the TRuE-AD clinical trial program has met its primary endpoint. [Incyte] Press Release

Bristol-Myers Squibb Advances CytomX Therapeutics’ Anti-CTLA-4 Probody Therapeutic BMS-986249 into Randomized Cohort Expansion (Part IIa) of Ongoing Clinical Trial

CytomX Therapeutics, Inc. announced that its partner, Bristol-Myers Squibb, has initiated a randomized Phase II cohort expansion in its ongoing first-in-human Phase I/IIa trial of the anti-CTLA-4 Probody BMS-986249 alone and in combination with Opdivo^®. [CytomX Therapeutics, Inc.] Press Release

Has the UK Science Minister Been Demoted?

A government reshuffle in the United Kingdom has born another new science minister – a position that has seen a revolving door of appointees, firings and resignations in recent years. The latest appointment also comes with an apparent political demotion for the role, which expert observers say is in conflict with a government that appears to have put research and innovation at the heart of its agenda. [Nature News] Editorial

NIH Hosts Nonhuman Primate Workshop amidst Increased Scrutiny of Monkey Research

More than three years after it hosted a workshop on the science and ethics of biomedical studies on monkeys, the National Institutes of Health (NIH) this week convened another workshop on nonhuman primate research. And much like the previous event, the meeting is drawing sharply divergent reactions from biomedical and animal advocacy groups. [ScienceInsider] Editorial

Animal Welfare Records Return to USDA Website

On February 18, the US Department of Agriculture replaced on its website the animal welfare records that the agency had removed in early 2017 and added records that had been generated since, as ordered by Congress, The Washington Post reports. These documents, unredacted and searchable, include thousands of reports from unannounced inspections at research labs as well as zoos, circuses, dog breeders, and other facilities. [The Scientist] Editorial

White House Formally Invites Public Comment on Open-Access Policies

The White House issued a notice seeking comment on its effort to enhance public access to federally funded research. It’s an old idea creating new controversy. White House Office of Science and Technology Policy Director Kelvin Droegemeier is pushing back against publishers that in December said the administration was quietly pursuing an executive order to require immediate free distribution of taxpayer funded research. [ScienceInsider] Editorial

NEW Tissue Stem Cell Regulation by Autonomous and Non-Autonomous Mechanisms
July 12-17, 2020
Ventura, California, United States

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NEW Postdoctoral Position – Bioinformatics or Statistical Genetics (University of California, San Francisco)

NEW Faculty Positions – Dermatology (Columbia University)

Senior Research Scientist – Sarcoma (Memorial Sloan Kettering Cancer Center)

Postdoctoral Position – Cancer Biology (Kentsis Research Group)

Researcher – Dermatopathology (Weill Cornell Medical College)

Postdoctoral Fellow – Cancer Pathogenesis (University of Cincinnati)

Postdoctoral Position – Tissue Repair and Inflammation (Memorial Sloan Kettering Cancer Center)

Postdoctoral Fellow – Cancer Research (University of California, San Diego)

Postdoctoral Fellowship – DNA Repair in Skin Melanoma Prevention (University of Southern California)

Postdoctoral Position – Microbiota and Autoimmunity (The University of Arizona)

Chief Position – Allergy, Immunology, Rheumatology and Dermatology (Harvard Medical School)

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