 | | Vol. 6.31 – 31 August, 2020 |
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| Cell-cell communication modeling suggested that basal cell populations served as crucial signaling hubs to maintain epidermal communication.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
| | DERMAL STEM CELLS & TISSUE REGENERATION |
| | By intersecting lipidomic datasets from suspension-induced differentiation and knockdown keratinocytes, scientists pinpointed candidate bioactive lipid subspecies as differentiation regulators.
[Proceedings of the National Academy of Sciences of the United States of America] |
| | Researchers found that the TCF7L2 E-isoforms maintained, whereas the M and S isoforms disrupted morphogenesis of 3D-epithelial cell-derived organoids via regulation of epithelial-mesenchymal transition.
[Cell Death & Disease] |
| | Scientists performed topical and systemic administration of terbinafine in reconstructed human skin (RHS) vs. a RHS plus liver model cultured in TissUse’ HUMIMIC Chip2.
[International Journal of Pharmaceutics] |
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| Clobetasol loaded lipid-polymer hybrid nanoparticles (CP/LPNs) showed an improved cellular uptake with significant growth inhibition of HaCaT cells. In ex vivo studies, these LPNs penetrated into the viable epidermis and dermis region of the psoriatic skin with undetectable quantities leaching to the reservoir.
[Acta Biomaterialia] |
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| Investigators demonstrated interleukin 32 (IL-32) expression in human melanoma positively correlated with overall survival, response to immune checkpoint blockade, and an immune inflamed tumor microenvironment enriched in mature dendritic cells, M1 macrophages and CD8+ T cells.
[JCI Insight] |
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| Researchers investigated the association of macrophage infiltration with prognosis and functional changes in the tumour microenvironment in primary human melanoma.
[British Journal of Cancer] |
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| Downregulation of apoptotic proteins such as HO-1 and Claspin along with the inhibition of the cleavage of Caspase-3 indicated the proteomic background of the altered responsiveness of the melanoma cells exposed to bortezomib and alpha-lipoic acid.
[Scientific Reports] |
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| In the human melanoma MeWo cell line, bestatin and bacitracin inhibited aminopeptidase N and dipeptidyl peptidase IV activities, reduced cell viability and increased DNA fragmentation, suggesting induction of apoptosis.
[International Journal of Biological Macromolecules] |
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| The authors explored the precise role and mechanism of p38 inhibiting cutaneous squamous cell carcinoma associated lincRNA (PICSAR) in cutaneous squamous-cell carcinoma.
[Life Sciences] |
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| Scientists discovered that circ_0079593 was highly expressed in melanoma, and its silencing suppressed melanoma cell proliferation, migration, invasion, glucose metabolism and promoted apoptosis
[Molecular and Cellular Biochemistry] |
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| The authors reveal that cannabinoids, individually or combined, reduce tumor growth and promote apoptosis and autophagy in melanoma cells.
[International Journal of Molecular Sciences] |
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| Scientists introduces four major topics of melanogenesis cascade that include melanocyte development and differentiation, melanogenesis and intracellular trafficking for melanosome biosynthesis, melanin pigmentation and pigment-type switching, and development of a novel therapeutic approach for malignant melanoma by elucidation of melanogenesis cascade.
[International Journal of Molecular Sciences] |
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| Krystal Biotech, Inc. announced the initiation of the PEARL-1 study, a Phase I multi-dose, controlled clinical study of KB301 for the treatment of acne scars and facial wrinkles.
[Krystal Biotech, Inc.] |
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| OncoSec Medical Inc. announced the commencement of an investigator-initiated Phase II study led by Dr. Ahmad A. Tarhini to evaluate its lead product candidate, TAVO™ in combination with intravenous OPDIVO® in up to 33 patients with operable locally/regionally advanced melanoma.
[OncoSec Medical Incorporated] |
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| November 18, 2020
Virtual |
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| | International Iberian Nanotechnology Laboratory – Braga, Portugal |
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| | Karolinska Institute – Stockholm, Sweden |
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| | University of North Carolina at Chapel Hill – Chapel Hill, North Carolina, United States |
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| | Pennsylvania State University – Philadelphia, Pennsylvania, United States |
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| | Terasaki Institute for Biomedical Innovation – Los Angeles, California, United States |
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