 | | Vol. 6.40 – 16 November, 2020 |
| |
|
|
|
Using single-cell RNA sequencing, lineage tracing, whole-organ explant, and live-cell imaging, investigators showed that homeostatic tympanic membrane epidermis was distinct from other epidermal sites and had discrete proliferative zones with a three-dimensional hierarchy of multiple keratinocyte populations.
[Cell Stem Cell] |
|  | | PUBLICATIONSRanked by the impact factor of the journal |
| | DERMAL STEM CELLS & TISSUE REGENERATION |
| | The authors used single-cell RNA sequencing with comparative gene expression analysis to elucidate the transcriptional dynamics of melanocyte stem cells through quiescence, activation, and melanocyte maturation.
[Genes & Development] |
| | Current treatments for nonhealing or chronic wounds were unsatisfactory as they exert a single effect on one specific activity in a process that involves multiple stages. Researchers constructed a silver nanowire-based, three-dimensional, porous foam dressing that was flexible and conductive.
[Biomaterials Science] |
| | In the preclinical trial on a dermal punch model of tissue repair, CPS successfully increased the rate of wound closure, reduced inflammatory cell infiltration, and enhanced collagen deposition. It could also relay changes in internal chemical signals into changes in its intrinsic luminescence for biphasic chemical sensing to prevent the possible occurrence of skin hyperpigmentation caused by minocycline hydrochloride in wound therapy.
[Advanced Healthcare Materials] |
| | Investigators found that the alcohol extract of Ajuga taiwanensis screened from a chemical bank exhibited a potent capacity for suppressing senescence associated biomarkers, including senescence-associated–β-galactosidase and up-regulated p53 in old human dermal fibroblasts without induction of significant cytotoxicity up to 100 µg/ml.
[Scientific Reports] |
| |
|
|
| Scientists showed that downregulation of the AP-1 transcription factor member Fra-2 in melanoma cells was associated with an aggressive melanoma phenotype in vitro and in vivo.
[Cell Death & Differentiation] |
|
|
|
| Employing an in-house human melanoma tissue microarray containing multiple cases of melanomas and benign nevi, coupled with high-throughput, multispectral quantitative fluorescence imaging analysis, researchers found a positive correlation between PLK1 and NOTCH1 in melanoma.
[Molecular Cancer Therapeutics] |
|
|
|
| Scientists focused on the analysis of microenvironmental factors introduced in melanoma heterogeneous spheroids by different dermal fibroblasts.
[Cancers] |
|
|
|
| Researchers evaluated the efficacy of Withaferin A, derived from the medicinal plant Withania Somnifera, as a novel therapeutic agent for the treatment of melanoma.
[Scientific Reports] |
|
|
|
|
| Investigators provide a comprehensive summary of the processes regulated by tumor-associated cells that promote the immune escape of melanoma cells.
[International Journal of Molecular Sciences] |
|
|
|
| The authors discuss the pathogenetic role of various cytokines in Hidradenitis suppurativa and potential therapeutic targets attempted or currently under investigation for this debilitating disease.
[International Journal of Molecular Sciences] |
|
|
|
|
| Biohaven Pharmaceutical Holding Company Ltd. announced that Dr. Richard Granstein, Chairman of Dermatology at Weill Cornell Medicine in New York City, will initiate an investigator-led clinical trial with a Biohaven CGRP-receptor antagonist for the treatment of plaque psoriasis.
[Biohaven Pharmaceutical Holding Company Ltd] |
|
|
|
| Innate Pharma SA announced that the European Medicines Agency granted PRIME designation to lacutamab, the company’s proprietary first-in-class anti-KIR3DL2 humanized cytotoxicity-inducing antibody, for the treatment of patients with relapsed or refractory Sézary syndrome who have received at least two prior systemic therapies.
[Innate Pharma SA] |
|
|
|
|
| April 9 – April 14, 2021
Washington, DC, United States |
|
|
|
|
|
| | University of Dundee – Dundee, Scotland, United Kingdom |
|
|
|
| | Stanford University – Stanford, California, United States |
|
|
|
| | University of California San Diego – La Jolla, California, United States |
|
|
|
| | Columbia University Medical Center – New York, New York, United States |
|
|
|
| | Duke University – Durham, North Carolina, United States |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
