 | | Vol. 6.41 – 23 November, 2020 |
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| Scientists described MelanoIP, a method for rapidly isolating melanosomes and profiling their labile metabolite contents. They used this method to study MFSD12, a transmembrane protein of unknown molecular function that, when suppressed, caused darker pigmentation in mice and humans.
[Nature] |
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| PUBLICATIONSRanked by the impact factor of the journal |
| | DERMAL STEM CELLS & TISSUE REGENERATION |
| | Researchers evaluated individual dendritic cell activation profiles in the context of keratinocytes by R‐OOHs with regard to frequency, specificity, and magnitude of upregulation.
[British Journal of Dermatology] |
| | Scientists found that the Tenascin C (TNC) mRNA level was significantly reduced in the skin tissues of aged mice compared with young mice, consistent with reduced TNC protein expression in aged human skin.
[International Journal of Molecular Sciences] |
| | As a step towards the development of wound healing agents, investigators utilized a human keratinocyte cell line as an in vitro model to define the potential molecular mechanisms of B. rotunda extract in enhancing wound healing.
[Biomedicine & Pharmacotherapy] |
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| The authors showed that single circulating tumor cells from melanoma patients coordinately upregulated lipogenesis and iron homeostasis pathways.
[Cancer Discovery] |
| | Investigators report a mechanism regulated by the oncogenic SOX2-GLI1 transcriptional complex driving melanoma invasion through the induction of the sialyltransferase ST3GAL1. Using in vitro and in vivo studies, they demonstrated that ST3GAL1 drove melanoma metastasis.
[Nature Communications] |
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| Researchers examined the effect of Lotus seedpod extract (LSE) on melanogenesis and the involved signaling pathways in vitro and in vivo. They showed that non-cytotoxic doses of LSE and its main component epigallocatechin reduced both tyrosinase activity and melanin production in the α-melanocyte stimulating hormone-induced melanoma cells.
[Nutrients] |
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| Scientists showed that acetylsalicylic acid and salicylic acid present anticancer effects against a murine model of implanted melanoma. These effects were also validated in 3D- and 2D-cultured melanoma B16F10 cells, where the drugs promoted pro-apoptotic effects.
[Scientific Reports] |
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| Scientists assessed whether 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) affected the development of atopic dermatitis (AD) in vitro and in vivo. The expression of 11β-HSD1 in the epidermis of AD lesions was higher than that in the epidermis of healthy controls.
[Scientific Reports] |
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| Investigators review the potential roles of the unfolded protein response/integrated stress response in the etiology of melanoma and vitiligo.
[Pigment Cell & Melanoma Research] |
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| With the significant role of oxidative phosphorylation (OXPHOS) in metabolic plasticity and symbiosis, the authors outline how mitochondrial transfer from mesenchymal stromal cells to melanoma tumor cells plays a key role in melanoma progression and is the mechanism by which melanoma cells regain OXPHOS capacity even in the presence of mitochondrial mutations.
[British Journal of Cancer] |
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| Arcutis Biotherapeutics, Inc. announced positive topline data from its Phase IIb clinical trial evaluating ARQ-154 as a potential treatment for scalp psoriasis. Roflumilast foam demonstrated statistically significant improvement on the trial’s primary and multiple secondary endpoints.
[Arcutis Biotherapeutics, Inc.] |
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| PharmaTher, Inc. filed a provisional patent application with the US Patent and Trademark Office outlining the potential novel use of psilocybin to treat cancer, which was discovered by panaceAI™, their proprietary psychedelic drug repurposing artificial intelligence platform.
[PharmaTher, Inc. (GlobeNewswire, Inc.)] |
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| April 11 – April 13, 2021
San Diego, California, United States |
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| | Universitätsklinikum Carl Gustav Carus Dresden – Dresden, Germany |
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| | NYU Langone Medical Center – New York, New York, United States |
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| | University of Dundee – Dundee, Scotland, United Kingdom |
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| | Stanford University – Stanford, California, United States |
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| | Columbia University Medical Center – New York, New York, United States |
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