 | | Vol. 6.44 – 14 December, 2020 |
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| Researchers performed an unbiased interrogation of tumor mesenchymal stem cells, delineating the co-existence of distinct subsets of cancer-associated fibroblasts in the microenvironment of murine carcinomas, each endowed with unique phenotypic features and functions.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
| | DERMAL STEM CELLS & TISSUE REGENERATION |
| | Scientists found that stem cell factor (SCF) expression in the epidermis was decreased in mouse models of delayed wound closure intended to mimic old age, obesity, and alcoholism. By using SCF conditionally knocked out mice, they demonstrated that keratinocytes’ autocrine production of SCF activates a transient c-kit receptor in keratinocytes.
[Scientific Reports] |
| | Investigators established an ex vivo burn wound model, where wounds were inflicted by applying preheated soldering iron to human skin explants, resulting in highly reproducible deep second-degree burn wounds.
[Scientific Reports] |
| | Human fibroblasts, keratinocytes, and endothelial cells were first treated with human gingival fibroblasts-conditioned media and showed improved migration, proliferation, and angiogenic functions.
[NPJ Regenerative Medicine] |
| | The authors showed that hyperglycemia blunted the hypoxia-dependent induction of miR-210 both in vitro and in human and mouse diabetic wounds.
[Communications Biology] |
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| miR-375 enrichment in Merkel cell carcinoma-derived extracellular vesicles suggests its intercellular signaling function. Investigators demonstrated that horizontally transferred miR-375 caused fibroblast polarization toward cancer-associated fibroblasts.
[Oncogene] |
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| The authors performed a preclinical study to evaluate whether nintedanib might enhance antitumor immunity by targeting cancer-associated fibroblasts and thereby improve the response to immune checkpoint blockade.
[British Journal of Cancer] |
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| Investigators demonstrated that activating transcription factor 3 (ATF-3) exhibited tumor suppressive function in melanoma. Significantly low expression of ATF-3 was found in cultured human metastatic melanoma cell lines.
[Laboratory Investigation] |
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| Scientists identified RP11-705C15.3, a regulator of miR-145-5p, as an oncogenic long non-coding RNA (lncRNA) in melanoma. RP11-705C15.3 competitively bound miR-145-5p, relieved the repressive roles of miR-145-5p on its target NRAS, upregulated NRAS expression, and activated MAPK signaling.
[Cancer Gene Therapy] |
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| The authors provide an update on the current state of knowledge on skin γδ T cell activation, regulation, and function in skin homeostasis and repair in mice and humans.
[International Journal of Molecular Sciences] |
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| Scientists evaluate the efficacy and safety of IL-23 inhibitors in the treatment of plaque psoriasis and psoriatic arthritis.
[American Journal of Clinical Dermatology] |
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| BioLab Sciences announced it has acquired the patents and intellectual property for MyOwn Skin™ from Bogota, Colombia-based Keraderm.
[BioLab Sciences (Business Wire, Inc)] |
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| AbbVie announced top-line results from the Phase IIIb Heads Up study showing that Upadacitinib achieved superiority to Dupilumab for the primary endpoint, the proportion of patients with at least a 75% improvement in the Eczema Area Severity Index at week 16, in adults with moderate to severe atopic dermatitis.
[AbbVie (PR Newswire, LLC)] |
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| BELLUS Health Inc. announced that the first patient has been dosed in the Phase II BLUEPRINT trial of BLU-5937, the company’s highly selective P2X3 antagonist, in patients with chronic pruritus associated with atopic dermatitis.
[BELLUS Health Inc.] |
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| January 13 – 14, 2021
Virtual |
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| | University of Texas MD Anderson Cancer Center – Houston, Texas, United States |
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| | Karolinska Institute – Stockholm, Sweden |
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| | University of Cincinnati – Cincinnati, Ohio, United States |
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| | Columbia University Medical Center – New York, New York, United States |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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