 | | Vol. 7.01 – 11 January, 2021 |
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| The authors describe a method of delivery of chondroitin sulfate to the skin as nanoparticles and demonstrated its anti-inflammatory and antioxidant role using UV irradiation as a model condition.
[ACS Applied Materials & Interfaces] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
| | DERMAL STEM CELLS & TISSUE REGENERATION |
| | The phenolic and terpenophenolic compounds were assayed in the water extract of the hemp variety Futura 75. Protective effects were also investigated in human fibroblast and keratinocytes and isolate mouse skin specimens, which were exposed to hydrogen peroxide and/or to the extract.
[Antioxidants] |
| | Scientists investigated whether IL‐10 alleviated lipopolysaccharide‐induced inflammatory response and skin scarring and explored the possible mechanism of scar formation.
[Journal of Cellular and Molecular Medicine] |
| | Proteomics analysis of octenidine dihydrochloride-treated skin wounds revealed significantly lower levels of key players in tissue remodeling as well as reepithelization after wounding such as pro-inflammatory cytokines and matrix-metalloproteinases when compared to controls.
[Scientific Reports] |
| | Researchers examined the anti-inflammatory effects of carbon dioxide (CO2) in human keratinocytes and skin. Keratinocytes were cultured under 15% CO2, irradiated with ultraviolet B (UVB), and their inflammatory cytokine production was analyzed.
[Scientific Reports] |
| | The authors demonstrated the capacity of human hair follicles for cholesterol transport and trafficking.
[Histochemistry and Cell Biology] |
| | The effects of Epidermal Growth Factor Receptor inhibitors (EGFRi) and Vascular Endothelial Growth Factor Receptor inhibitors at therapeutically relevant concentrations were assessed on proliferation and differentiation markers of human keratinocytes in a novel 3D micro-epidermis tissue culture model.
[BMC Cancer] |
| | | CRO15 exerted anti-melanoma effects on cells lines and cells isolated from patients including the ones derived from tumors resistant to BRAF inhibitor
[Cell Death & Disease] |
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| Scientists investigated the mechanism of metastasis in highly metastatic melanoma and breast cancer cells, and the mechanism of inhibition of metastasis by rhosin.
[Biomedicines] |
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| Investigators presented the action of the B-Raf serine-threonine protein kinase inhibitor (vemurafenib) on the glycans structure and metallomics profiles in melanoma cells without and with BRAF mutations.
[International Journal of Molecular Sciences] |
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| Researchers assessed miR-675-3p-related regulatory mechanisms in melanoma and the clinical relevance of such regulatory activities.
[Human Cell] |
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| The authors discuss the progress made since the last Melanoma Research Foundation assessment, comment on what remains to be overcome, and offer recommendations for the best path forward.
[Clinical Cancer Research] |
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| InMed Pharmaceuticals Inc. announced top-line results from its 755-102-HV Phase I clinical trial. Results of the study indicate that INM-755 cream was safe and well-tolerated on induced open epidermal wounds, caused no systemic or serious adverse effects, and there were no subject withdrawals due to adverse events.
[InMed Pharmaceuticals Inc.] |
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| Istari Oncology, Inc. announced that the FDA has granted orphan drug designation for PVSRIPO for the treatment of advanced melanoma. PVSRIPO is a novel viral immunotherapy, based on the Sabin type 1 polio vaccine, that activates a patient’s innate and adaptive immune system to facilitate an anti-tumor response and establish long-term immunologic memory to help prevent the cancer’s return.
[Istari Oncology, Inc.] |
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| January 25 – 28, 2021
Virtual |
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| | STEMCELL Technologies, Inc. – Burnaby, British Columbia, Canada |
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| | Fondazione Human Technopole – Milan, Italy |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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| | Columbia University Medical Center – New York, New York, United States |
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| | University of Cincinnati – Cincinnati, Ohio, United States |
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