 | | Vol. 7.02 – 18 January, 2021 |
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| The authors demonstrated there to be a dispersal of phosphorylated Lamin A/C to structures throughout the cytoplasm in differentiating keratinocytes.
[Cell Death & Differentiation] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
| | DERMAL STEM CELLS & TISSUE REGENERATION |
| | Researchers demonstrated that altered dendritic cell representation in the skin-draining lymph nodes during sensitization to allergens caused Th2-driven contact hypersensitivity.
[Proceedings of the National Academy of Sciences of the United States of America] |
| | Investigators sequenced genomes of single cell-derived clonal lineages obtained from primary skin cells of a large cohort of healthy individuals across a wide range of ages.
[PLoS Genetics] |
| | Scientists investigated whether human interfollicular epidermal keratinocytes with stem-like features, characterized by an α6bri/CD71dim expression, could replace human hair follicular keratinocytes for the recreation of the hair follicle epithelium and respective epithelial-mesenchymal interactions.
[Stem Cell Research & Therapy] |
| | The authors investigated the efficacy of Omega-7 isolated from the sea buckthorn oil in ovine burn wound healing models. In vitro, proliferation and migration assays using cultured primary ovine keratinocytes were performed with or without 0.025% and 0.08% Omega-7, respectively.
[Scientific Reports] |
| | Dermal fibroblasts (DF) are critical for effective wound healing, so scientists sought to establish whether there were any differences in DF cultured from Type 2 diabetes mellitus donors or those without diabetes.
[Scientific Reports] |
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| Investigators showed that MITF, the master transcription factor in melanocytes, controlled ubiquitination in melanoma cells. They identified FBXO32, a component of the SCF E3 ligase complex as a new MITF target gene.
[Cell Death & Differentiation] |
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| Scientists identified lncRNA SPRR2C (small proline-rich protein 2C) as a hub gene with a critical effect on the pathogenesis of psoriasis and response to treatment using both weighted gene coexpression network analysis and differential expression analysis. SPRR2C expression was significantly upregulated in both psoriatic lesion samples and HaCaT cell lines in response to IL-22 treatment.
[Cell Death & Disease] |
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| Researchers showed that the increase in glucose uptake and mitochondrial oxidative phosphorylation confers metastatic ability as a result of aryl hydrocarbon receptor nuclear translocator (ARNT) deficiency.
[Oncogenesis] |
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| Scientists describe the mechanisms whereby adipose‐derived stem cells‐exosomes regulate wound healing and their clinical application.
[Cell Proliferation] |
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| The ubiquitin proteasome system is a key regulatory factor in the proliferation, differentiation, and collagen secretion of skin fibroblasts.
[Molecular Diagnosis & Therapy] |
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| InflaRx N.V. provided an update on the ongoing development of IFX-1, a first-in-class anti-C5a antibody. The company announced plans to start an open label, multicenter Phase II study evaluating IFX-1 alone and in combination with pembrolizumab in patients with PD-1 or PD-L1 inhibitor resistant/refractory locally advanced or metastatic cutaneous squamous cell carcinoma.
[InflaRx N.V.] |
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| Sirnaomics, Inc. announced dose administration for the first patient in a Phase IIa clinical study of the company’s lead drug candidate, STP705, for the treatment of cutaneous basal cell carcinoma.
[Sirnaomics, Inc.] |
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| February 3 – 23, 2021
Virtual |
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| | Harvard Medical School – Boston, Massachusetts, United States |
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| | The Francis Crick Institute – London, England, United Kingdom |
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| | Novo Nordisk – Copenhagen, Denmark |
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| | STEMCELL Technologies, Inc. – Burnaby, British Columbia, Canada |
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| | Fondazione Human Technopole – Milan, Italy |
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