Dermal Cell News Volume 7.10 | Mar 22 2021

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    2021-03-22 | DCN 7.10


    Dermal Cell News by STEMCELL Technologies
    Vol. 7.10 – 22 March, 2021
    TOP STORY

    Melanoma Subpopulations That Rapidly Escape MAPK Pathway Inhibition Incur DNA Damage and Rely on Stress Signaling

    Investigators tracked the responses of thousands of single melanoma cells to BRAF inhibitors and showed that a subset of cells escaped drug via non-genetic mechanisms within the first three days of treatment.
    [Nature Communications]

    Full Article


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    PUBLICATIONSRanked by the impact factor of the journal

    CRISPR Screens Identify Tumor‐Promoting Genes Conferring Melanoma Cell Plasticity and Resistance

    Using a CRISPR activation screening, scientists identified genes involved in BRAF inhibitor (BRAFi) resistance in cutaneous melanoma. Their upregulation promoted tumor growth of therapy‐naïve melanoma cells and BRAFi‐resistance.
    [EMBO Molecular Medicine]

    Full ArticleGraphical Abstract

    TBX3 Promotes Melanoma Migration by Transcriptional Activation of ID1 Which Prevents Activation of E-Cadherin by MITF

    Investigators showed that TBX3 directly promotes expression of ID1, a dominant-negative regulator of basic-helix-loop helix transcription factors, and that ID1 decreases microphthalmia-associated transcription factors (MITFs) binding and upregulation of E-cadherin.
    [Journal of Investigative Dermatology]

    Full ArticleGraphical Abstract

    Dasatinib Stimulates Its Own Mechanism of Resistance by Activating a CRTC3/MITF/Bcl-2 Pathway in Melanoma with Mutant or Amplified C-Kit

    Researchers showed that dasatinib in melanoma stimulated its proper mechanism of resistance, independently of MAPK and PI3K/AKT pathway reactivation commonly associated to secondary c-Kit mutations, but through CRTC3/MITF/Bcl-2 pathway activation at clinically relevant doses.
    [Molecular Cancer Research]

    Abstract

    Exosomal miR-106b-5p Derived from Melanoma Cell Promotes Primary Melanocytes Epithelial-Mesenchymal Transition through Targeting EphA4

    miR-106b-5p was enriched in melanoma cell-secreted exosomes and transferred to melanocytes. Exosomal miR-106b-5p promoted the epithelial-to-mesenchymal transition, migration, invasion and adhesion of melanocytes. Exosomal miR-106b-5p exerted its role by targeting erythropoietin-producing hepatocellular carcinoma receptor A4 (EphA4) to activate the ERK pathway.
    [Journal of Experimental & Clinical Cancer Research]

    Full Article

    Mechanical Instability of Adherens Junctions Overrides Intrinsic Quiescence of Hair Follicle Stem Cells

    Researchers demonstrated that vinculin functions by keeping α-catenin in a stretched/open conformation which in turn regulated the retention of YAP1, another potent mechanotransducer and regulator of cell proliferation, at the adherens junctions.
    [Developmental Cell]

    Full ArticleGraphical Abstract

    Effects of Metal Nanoparticles on Tight Junction-Associated Proteins via HIF-1α/miR-29b/MMPs Pathway in Human Epidermal Keratinocytes

    Scientists demonstrated that exposure of human epidermal keratinocytes to Nano-Ni caused increased HIF-1α nuclear accumulation and increased transcription and activity of MMP-2 and MMP-9 and down-regulation of miR-29b and tight junction-associated proteins.
    [Particle and Fibre Toxicology]

    Full Article

    Chitosan Hydrogel-Loaded MSC-Derived Extracellular Vesicles Promote Skin Rejuvenation by Ameliorating the Senescence of Dermal Fibroblasts

    Chitosan (CS) hydrogel-encapsulated extracellular vesicles could delay the skin aging processes by ameliorating the function of aging dermal fibroblasts. Researchers also highlighted the potential of CS hydrogel-encapsulated extracellular vesicles as a novel therapeutic strategy for improving aging skin to rejuvenation.
    [Stem Cell Research & Therapy]

    Full Article

    Distinct Types of Stem Cell Divisions Determine Organ Regeneration and Aging in Hair Follicles

    The authors report that hair follicle stem cells lost their regenerative capabilities during aging owing to the adoption of an atypical cell division program.
    [Nature Aging]

    Abstract

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    REVIEWS

    Will Mesenchymal Stem Cells Be Future Directions for Treating Radiation-Induced Skin Injury?

    Scientists not only discussed different sources of mesenchymal stem cells (MSCs) on the treatment of radiation-induced skin injury both in preclinical studies and clinical trials, but also summarized the applications and mechanisms of MSCs in other related regenerative fields.
    [Stem Cell Research & Therapy]

    Full Article

    Tracing Skin Aging Process: A Mini-Review of In Vitro Approaches

    The authors present in vitro methods for assessments of skin aging in an attempt to pinpoint basic molecular mechanisms behind this process achieving both a better understanding of aging function and an effective evaluation of potential products or ingredients that counteract aging.
    [Biogerontology]

    Abstract

    INDUSTRY AND POLICY NEWS

    Fortress Biotech’s Partner Company, Journey Medical Corporation, In-licenses and Launches Accutane® for the Treatment of Severe Recalcitrant Nodular Acne

    Fortress Biotech, Inc. announced that Journey Medical Corporation, a partner company of Fortress, in-licensed and launched an oral isotretinoin under the brand name Accutane® in the U.S. Accutane is an oral medication that is indicated for the treatment of severe recalcitrant nodular acne.
    [Fortress Biotech, Inc.]

    Press Release

    FEATURED EVENT

    EMBO Workshop: Long-Distance Cell-Cell Signaling in Development and Disease

    September 5 – 8, 2021
    Exeter, England, United Kingdom

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Diet and Melanoma

    MD Anderson Cancer Center – Houston, Texas, United States

    Postdoctoral Fellow – Signaling Pathways and Melanoma

    The Wistar Institute – Philadelphia, Pennsylvania, United States

    Postdoctoral Scholar – Immune Responses in Human Skin and Mucosal Surfaces

    University of Washington – Seattle, Washington, United States

    Postdoctoral Fellow – Experimental Dermatology

    University of British Columbia – Vancouver, British Columbia, Canada

    Associate Researcher – Developmental and Regenerative Biology

    Mount Sinai Health System – New York, New York, United States

    > See All Jobs

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