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| Researchers studied 37 tumor samples over nine years from a patient with metastatic melanoma with complete clinical response to immune checkpoint blockade followed by delayed recurrence and death.
[Nature Medicine] |
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| PUBLICATIONSRanked by the impact factor of the journal |
| | DERMAL STEM CELLS & TISSUE REGENERATION |
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| By tracking individual cells in the skin of live adult mice over time, researchers showed that Langerhans cells and dendritic epidermal T cells actively maintained a non-random spatial distribution despite continuous turnover of neighboring basal epithelial cells.
[Nature Cell Biology] |
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| Scientists reported that single-cell transcriptome analysis of primary human epidermal cultures identified categories of genes clearly distinguishing the different keratinocyte clonal types, which were hierarchically organized along a continuous, mainly linear trajectory showing that stem cells sequentially generated progenitors producing terminally differentiated cells.
[Nature Communications] |
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| The epithelial–fibroblast interface, namely, hair germ–dermal papilla interface, makes asymmetrically organized side-specific heterogeneity in the basement membrane (BM), defined by the newly characterized interface, hook and mesh BMs.
[Nature Communications] |
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| Investigators deconstructed the full-thickness human skins of both healthy donors and patients with psoriasis vulgaris at single cell transcriptional level, and further built a neural-network classifier to evaluate the evolutional conservation of skin cell types between mouse and human.
[Cell Death & Disease] |
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| Scientists measured mTOR-STAT3 signaling in skin fibroblasts and found that phosphorylated mTOR and phosphorylated STAT3 protein expression were decreased by metformin treatment.
[Journal of Translational Medicine] |
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| Scientists provided evidence that the Activating Molecule in Beclin-1-Regulated Autophagy (Ambra1) contributed to melanoma development.
[Nature Communications] |
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| Researchers identified a novel SOX2-BRD4 transcriptional complex driving the expression of GLI1, the final effector of the Hedgehog/GLI (HH/GLI) pathway, providing a novel mechanism of non-canonical Smoothened-independent activation of HH/GLI signaling in melanoma.
[Oncogene] |
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| Scientists showed that although dermal injection of colony stimulating factor 1 increased the local abundance of macrophages in the skin, this did not affect susceptibility to intradermal T. brucei infection.
[Scientific Reports] |
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| The authors review the latest progress in hypoxia-regulated pathways involved in the development and progression of all melanoma subtypes.
[Journal of Experimental & Clinical Cancer Research] |
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| The authors summarizes the mechanisms of several common neuropeptides in atopic dermatitis (AD) and hypothesize that neuropeptides may be the novel potential targets in AD treatment.
[Experimental Dermatology] |
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| Checkmate Pharmaceuticals, Inc. announced the development program expansion of vidutolimod into non-melanoma skin cancers in combination with Libtayo® under a clinical supply agreement with Regeneron Pharmaceuticals, Inc.
[Checkmate Pharmaceuticals, Inc. (Business Wire, Inc.)] |
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| June 5 – 10, 2022
Ventura, California, United States |
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| | University of Copenhagen – Copenhagen, Denmark |
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| | University of Maryland – Baltimore, United States |
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| | UCLA – Los Angeles, California, United States |
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| | National Institutes of Health – Bethesda, Maryland, United States |
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| | Howard Hughes Medical Institute – New York, New York, United States |
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