Dermal Cell News Volume 7.20 | Jun 7 2021

    0
    79








    Subject


    Dermal Cell News by STEMCELL Technologies
    Vol. 7.20 – 7 June, 2021
    TOP STORY

    Lgr6 Marks Epidermal Stem Cells with a Nerve-Dependent Role in Wound Re-Epithelialization

    Scientists demonstrated that Lgr6 marked a regionally restricted population of epidermal stem cells that interacted with nerves and specialized in wound re-epithelialization.
    [Cell Stem Cell]

    AbstractGraphical Abstract

    Request your free copy of the 'Growing Organoids from Stem Cells' Wallchart
    PUBLICATIONSRanked by the impact factor of the journal
    DERMAL STEM CELLS & TISSUE REGENERATION

    A Small Molecule HIF-1α Stabilizer That Accelerates Diabetic Wound Healing

    In vitro biophysical and cellular analyses demonstrated that cyclometalated iridium(III) metal complex 1a bound to Von Hippel-Lindau (VHL) and inhibited the VHL–hypoxia-inducible factor-1α (HIF)-1α interaction.
    [Nature Communications]

    Full Article

    Single-Cell RNA Sequencing of Human Nail Unit Defines RSPO4 Onychofibroblasts and SPINK6 Nail Epithelium

    Researchers studied transcriptome profiles of human nail units using polydactyly specimens. SPINK6 expression distinguished the nail-specific keratinocytes from epidermal keratinocytes.
    [Communications Biology]

    Full Article

    A Novel Mineralocorticoid Receptor Antagonist, 7,3′, 4′-Trihydroxyisoflavone Improves Skin Barrier Function Impaired by Endogenous or Exogenous Glucocorticoids

    Investigators examined whether mineralocorticoid receptor antagonists could ameliorate glucocorticoid receptor-mediated skin barrier dysfunction in normal human epidermal keratinocytes, reconstructed human epidermis, and subjects under psychological stress.
    [Scientific Reports]

    Full Article

    3D Cell Culture Using a Clinostat Reproduces Microgravity-Induced Skin Changes

    Researchers used a previously developed 3D clinostat to simulate a microgravity environment and investigated whether physiological changes of the skin could be reproduced in a 3D in vitro setting.
    [NPJ Microgravity]

    Full Article

    SKIN CANCERS & DISORDERS

    Blockade of the Co-Inhibitory Molecule PD-1 Unleashes ILC2-Dependent Antitumor Immunity in Melanoma

    Scientists found that high group 2 innate lymphoid cells (ILC2) infiltration in human melanoma was associated with a good clinical prognosis. ILC2s were critical producers of the cytokine granulocyte-macrophage colony-stimulating factor, which coordinated the recruitment and activation of eosinophils to enhance antitumor responses.
    [Nature Immunology]

    Full Article

    Propionic Acid Produced by Cutibacterium acnes Fermentation Ameliorates Ultraviolet B-Induced Melanin Synthesis

    The authors identified a natural acidic formulation to reduce skin pigmentation. The metabolite propionic acid was the most abundant fatty acid in the filtrate from Pluronic F68 fermentation of Cutibacterium acnes and reduced the DOPA-positive melanocytes by significantly inhibiting cellular tyrosinase activity via binding to the free fatty acid receptor 2.
    [Scientific Reports]

    Full Article

    PARP Inhibitors Talazoparib and Niraparib Sensitize Melanoma Cells to Ionizing Radiation

    The effects of Talazoparib and Niraparib in combination with ionizing radiation on cell death, clonogenicity and cell cycle arrest were studied in healthy primary fibroblasts and primary melanoma cells.
    [Genes]

    Abstract

    Induction of T Helper 17 Cell Response by Interleukin-7 in Patients with Primary Cutaneous Melanoma

    Investigators assessed the effect of interleukin-7 signaling on T helper 17 responses in patients with primary cutaneous melanoma.
    [Melanoma Research]

    Abstract

    Return to your lab safely and efficiently with these guides and resources so that you can focus more on moving your research goals forward.
    REVIEWS

    Non-Coding RNAs in Melanoma: Biological Functions and Potential Clinical Applications

    The authors summarize the recent research progress on the effects of non-coding RNAs (ncRNAs) on melanoma and attempt to elucidate the role of ncRNAs as molecular markers or potential targets will provide promising application perspectives of melanoma.
    [Molecular Therapy-Oncolytics]

    AbstractGraphical Abstract

    INDUSTRY AND POLICY NEWS

    Fish Skin Company Kerecis Announces Kerecis Omega3 MicroGraft

    Kerecis, Inc. announced the release of Kerecis® Omega3 MicroGraft. The easy-to-use product is intact fish skin divided into fragments, which mold into wound beds.
    [Kerecis, Inc. (BusinessWire, Inc.)]

    Press Release

    Apyx Medical Corporation Announces FDA 510(k) Submission for the Use of Renuvion® in Dermal Resurfacing Procedures

    Apyx Medical Corporation announced it has submitted a 510(k) premarket notification to the US FDA, which is intended to obtain a specific clinical indication for the use of Renuvion® in dermal resurfacing procedures.
    [Apyx Medical Corporation (BusinessWire, Inc.)]

    Press Release

    FEATURED EVENT

    EMBO: Molecular Mechanisms of Aging and Regeneration: From Hydra to Humans

    September 6 – 10, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Researcher – Skin/Tissue Adhesive

    Ulsan National Institute of Science and Technology – Ulsan, South Korea

    Postdoctoral Fellow – Cutaneous Biology

    University of Michigan – Ann Arbor, Michigan, United States

    Principal Bioinformatician – Skin Cancers

    Wellcome Trust Sanger Institute – Cambridge, England, United Kingdom

    Group Leader – Skin Immunology

    University of Copenhagen – Copenhagen, Denmark

    Postdoctoral Fellow – Functional Genomics and Epigenomic Regulation

    National Institutes of Health – Bethesda, Maryland, United States

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Dermal Cell News Twitter