 | | Vol. 7.28 – 9 August, 2021 |
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| The authors demonstrated that mice lacking the hypoxia-inducible factor-1α isoform in natural killer (NK) cells showed impaired release of the cytokines Interferon (IFN)-γ and granulocyte macrophage – colony stimulating factor as part of a blunted immune response.
[Nature Communications] |
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| PUBLICATIONSRanked by the impact factor of the journal |
| | DERMAL STEM CELLS & TISSUE REGENERATION |
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| Microchannelled alkylated chitosan sponge demonstrated promising clinical translational potential in treating lethal noncompressible hemorrhage and facilitating wound healing.
[Nature Communications] |
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| Genetic variation in MC1R is a main determinant of red hair color phenotype and confers susceptibility to skin disorders. Scientists assessed the effects and function of MC1R variants identified in their clinical cohort of 135,947 participants with available exome sequencing using phenome-wide association scan.
[Genetics in Medicine] |
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| Through a combination of in vitro assays, mouse models, and intravital imaging, researchers found that S. aureus immune evasion in skin was controlled by a cascade composed of the ArlRS two-component regulatory system and its downstream effector, MgrA.
[Cell Reports] |
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| Scientists found that the expression of matrix metallopeptidase 1 (MMP1) was up-regulated in cutaneous squamous cell carcinoma (CSCC) cells, and knockdown of MMP1 suppressed cell proliferation and invasion in CSCC.
[Cancer Biology & Therapy] |
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| Investigators identified fermitin family member 2 as a potential target in A375 cell line by siRNA library screening. They also validated the tumor suppressive role of kindlin-2 in vitro and in vivo.
[Oncogene] |
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| Researchers found that miR-22 facilitated β-catenin stabilization through directly repressing citrullinase PAD2.
[Oncogene] |
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| By tracking cell lineages over multiple days, the authors established that these cells indeed proliferated more than neighboring cells, thus establishing that rapid signaling reactivation predicts long-term vemurafenib resistance.
[Scientific Reports] |
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| Human dermal papilla cells, isolated fresh hair follicles, and mouse back skin were exposed with the non-thermal atmospheric pressure plasma. Biological outcomes were measured using RNA-sequencing, RT-PCR, Western blots, and immunostaining.
[Scientific Reports] |
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| Skin cancer with its sub-types are explained in a nutshell, followed by compendium of specific nanotechnological tools presented, in addition to therapeutic applications of drug-loaded nano systems for skin cancer.
[Journal of Controlled Release] |
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| Castle Biosciences, Inc. announced its continued collaboration with the Melanoma Research Foundation, a non-profit organization leading the melanoma community to transform melanoma from one of the deadliest cancers to one of the most treatable through research, education and advocacy.
[Castle Biosciences, Inc.] |
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| Portage Biotech Inc., announced that the first patient has been dosed in the Oxford-led IMP-MEL study, a Phase I/II, open-label, dose-escalation and randomized expansion clinical trial assessing the safety, tolerability and efficacy of PORT-2, a liposome formulation of the invariant natural killer T-cell agonist IMM60 developed for the treatment of solid tumors.
[Portage Biotech Inc.] |
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| November 22 – 23, 2021
Ghent, Belgium |
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| | The Scripps Research Institute – La Jolla, California, United States |
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| | Buck Institute for Research on Aging – Novato, California, United States |
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| | University of Gothenburg – Gothenburg, Sweden |
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| | Dalhousie University – Halifax, Nova Scotia, Canada |
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| CRUK Manchester Institute – Manchester, England, United Kingdom |
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