| Vol. 7.38 – 1 November, 2021 |
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| Scientists profiled early- versus late-stage skin wound macrophages in mice at both the transcriptional and functional levels and found that glycolytic metabolism in the early phase was not sufficient to ensure productive repair. [Cell Metabolism] |
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PUBLICATIONSRanked by the impact factor of the journal |
| DERMAL STEM CELLS & TISSUE REGENERATION |
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| The authors investigated mature human hypertrophic scars and developing scars in mice at single cell resolution. They delineated the genetic landscape of hypertrophic scars and presented insights into mechanisms involved in hypertrophic scar formation. [Nature Communications] |
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| Investigators evaluated the application of injectable platelet rich fibrin (i-PRF) in human hair follicle regeneration and examined the biological effects of i-PRF on human dermal papilla cells. [Experimental Cell Research] |
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| Researchers reported that chlorogenic acid treatment induced production of procollagen type I in human dermal fibroblast, Hs68 cell lines. [Biochemical and Biophysical Research Communications] |
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| Scientists showed that testosterone promoted melanoma proliferation by activating ZIP9, a zinc transporter that was widely expressed in human melanoma but not intentionally targeted by available therapeutics. [Cancer Research] |
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| The authors identified the role of p32 in the malignancy of both murine and human melanoma and found that p32 knockdown led to reduced cell proliferation, migration, and invasion in murine and human melanoma cells. [Cell Death & Disease] |
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| Investigators explored a previously unrecognized role for ferroptosis in psoriasis, where ferroptosis was mediated by lipid peroxidation and iron overload. They found that ferrostatin-1 blocked inflammatory responses in vitro and in vivo, which reduced cytokine production. [Cell Death & Disease] |
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| Researchers found that proteasome 26 S subunit ATPase 2 (PSMC2) was significantly upregulated in skin cutaneous melanoma (SKCM) patients from The Cancer Genome Atlas datasets and verified in clinical SKCM tissues. [Cell Death Discovery] |
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| To study Hsp70 forms released from cells, scientists employed the assay consisting of two affinity chromatography methods. Hsp70 content in culture medium and extracellular vesicles was measured with the aid of ELISA. [Scientific Reports] |
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| The authors assess the effects of phototherapy for treating atopic eczema, a treatment used when topical treatments, such as corticosteroids, are insufficient or poorly tolerated. [Cochrane Database of Systematic Reviews] |
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| Investigators verify the effectiveness of intravenous immunoglobulins (IVIG) on systemic sclerosis (SSc) skin involvement and conduct a systematic review of the literature of the results obtained to date on the use of IVIG in SSc. [Autoimmunity Reviews] |
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| Scientists propose how the master redox regulators are maintained and activated in the different conditions experienced by the skin and how the lack of redox regulation is involved in the accumulation of several oxidation endproducts that are correlated with several skin disorders. [Journal of the European Academy of Dermatology and Venereology] |
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| Krystal Biotech, Inc. announced that the last participant has completed the GEM-3 study, Krystal’s pivotal Phase III clinical trial evaluating investigational beremagene geperpavec (B-VEC) as a topical gene therapy for the treatment of dystrophic epidermolysis bullosa. [Krystal Biotech, Inc.] |
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| Incyte, Inc. announced the validation of the European Marketing Authorization Application for ruxolitinib cream, a topical JAK inhibitor, as a potential treatment for adolescents and adults with non-segmental vitiligo with facial involvement. [Incyte, Inc.] |
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| November 10 – 11, 2021 Seoul, Korea & Online |
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| The University of British Columbia – Vancouver, British Columbia, Canada |
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| Columbia University Medical Center – New York, New York, United States |
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| The University of New Mexico – Albuquerque, New Mexico, United States |
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| Novo Nordisk – Indianapolis, Indiana, United States |
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| University of Minnesota – Austin, Minnesota, United States |
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