Dermal Cell News Volume 7.38 | Nov 1 2021

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    2021-11-01 | DCN 7.38


    Dermal Cell News by STEMCELL Technologies
    Vol. 7.38 – 1 November, 2021
    TOP STORY

    Mitochondrial Metabolism Coordinates Stage-Specific Repair Processes in Macrophages during Wound Healing

    Scientists profiled early- versus late-stage skin wound macrophages in mice at both the transcriptional and functional levels and found that glycolytic metabolism in the early phase was not sufficient to ensure productive repair.
    [Cell Metabolism]

    Full ArticleGraphical Abstract
    Guide to everything you need to know about cell separation.
    PUBLICATIONSRanked by the impact factor of the journal

    The Serine Proteases Dipeptidyl-Peptidase 4 and Urokinase Are Key Molecules in Human and Mouse Scar Formation

    The authors investigated mature human hypertrophic scars and developing scars in mice at single cell resolution. They delineated the genetic landscape of hypertrophic scars and presented insights into mechanisms involved in hypertrophic scar formation.
    [Nature Communications]

    Full Article

    Injectable Platelet Rich Fibrin Facilitates Hair Follicle Regeneration by Promoting Human Dermal Papilla Cell Proliferation, Migration, and Trichogenic Inductivity

    Investigators evaluated the application of injectable platelet rich fibrin (i-PRF) in human hair follicle regeneration and examined the biological effects of i-PRF on human dermal papilla cells.
    [Experimental Cell Research]

    Full Article

    Impact of Chlorogenic Acid on Modulation of Significant Genes in Dermal Fibroblasts and Epidermal Keratinocytes

    Researchers reported that chlorogenic acid treatment induced production of procollagen type I in human dermal fibroblast, Hs68 cell lines.
    [Biochemical and Biophysical Research Communications]

    Abstract

    ZIP9 is a Druggable Determinant of Sex Differences in Melanoma

    Scientists showed that testosterone promoted melanoma proliferation by activating ZIP9, a zinc transporter that was widely expressed in human melanoma but not intentionally targeted by available therapeutics.
    [Cancer Research]

    AbstractPress Release

    p32 Promotes Melanoma Progression and Metastasis by Targeting EMT Markers, Akt/PKB Pathway, and Tumor Microenvironment

    The authors identified the role of p32 in the malignancy of both murine and human melanoma and found that p32 knockdown led to reduced cell proliferation, migration, and invasion in murine and human melanoma cells.
    [Cell Death & Disease]

    Full Article

    Inhibition of Keratinocyte Ferroptosis Suppresses Psoriatic Inflammation

    Investigators explored a previously unrecognized role for ferroptosis in psoriasis, where ferroptosis was mediated by lipid peroxidation and iron overload. They found that ferrostatin-1 blocked inflammatory responses in vitro and in vivo, which reduced cytokine production.
    [Cell Death & Disease]

    Full Article

    PSMC2 Knockdown Suppressed Tumor Progression of Skin Cutaneous Melanoma

    Researchers found that proteasome 26 S subunit ATPase 2 (PSMC2) was significantly upregulated in skin cutaneous melanoma (SKCM) patients from The Cancer Genome Atlas datasets and verified in clinical SKCM tissues.
    [Cell Death Discovery]

    Full Article

    Hsp70-Containing Extracellular Vesicles Are Capable of Activating of Adaptive Immunity in Models of Mouse Melanoma and Colon Carcinoma

    To study Hsp70 forms released from cells, scientists employed the assay consisting of two affinity chromatography methods. Hsp70 content in culture medium and extracellular vesicles was measured with the aid of ELISA.
    [Scientific Reports]

    Full Article
    Resources for Your T Cell Therapy Research
    REVIEWS

    Phototherapy for Atopic Eczema

    The authors assess the effects of phototherapy for treating atopic eczema, a treatment used when topical treatments, such as corticosteroids, are insufficient or poorly tolerated.
    [Cochrane Database of Systematic Reviews]

    Abstract

    Intravenous Immunoglobulins Reduce Skin Thickness in Systemic Sclerosis: Evidence from Systematic Literature Review and from Real Life Experience

    Investigators verify the effectiveness of intravenous immunoglobulins (IVIG) on systemic sclerosis (SSc) skin involvement and conduct a systematic review of the literature of the results obtained to date on the use of IVIG in SSc.
    [Autoimmunity Reviews]

    Abstract

    The Skin Redoxome

    Scientists propose how the master redox regulators are maintained and activated in the different conditions experienced by the skin and how the lack of redox regulation is involved in the accumulation of several oxidation endproducts that are correlated with several skin disorders.
    [Journal of the European Academy of Dermatology and Venereology]

    Abstract
    INDUSTRY AND POLICY NEWS

    Krystal Biotech Announces Completion of the GEM-3 Pivotal Phase III Study Evaluating B-VEC for the Treatment of Dystrophic Epidermolysis Bullosa

    Krystal Biotech, Inc. announced that the last participant has completed the GEM-3 study, Krystal’s pivotal Phase III clinical trial evaluating investigational beremagene geperpavec (B-VEC) as a topical gene therapy for the treatment of dystrophic epidermolysis bullosa.
    [Krystal Biotech, Inc.]

    Press Release

    Incyte Announces the Validation of the European Marketing Authorization Application for Ruxolitinib Cream in Vitiligo

    Incyte, Inc. announced the validation of the European Marketing Authorization Application for ruxolitinib cream, a topical JAK inhibitor, as a potential treatment for adolescents and adults with non-segmental vitiligo with facial involvement.
    [Incyte, Inc.]

    Press Release
    FEATURED EVENT

    2nd AACR-KCA Conference on Precision Medicine in Solid Tumors

    November 10 – 11, 2021
    Seoul, Korea & Online

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Wound Healing

    The University of British Columbia – Vancouver, British Columbia, Canada

    Associate Professor – Translational Skin Cancer

    Columbia University Medical Center – New York, New York, United States

    Faculty and Leadership Positions – Cancer-Focused Target and Drug Discovery

    The University of New Mexico – Albuquerque, New Mexico, United States

    Scientist – Endocrine Disease Specialist

    Novo Nordisk – Indianapolis, Indiana, United States

    Postdoctoral Associate – Skin Tumorigenesis

    University of Minnesota – Austin, Minnesota, United States

    > See All Jobs

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