 | | Vol. 7.39 – 8 November, 2021 |
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| Investigators discovered that proteoglycan Agrin was enriched within the early wound-microenvironment and was indispensable for efficient healing.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
| | DERMAL STEM CELLS & TISSUE REGENERATION |
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| The authors suggested that Graphene Oxide loaded with vanadium doped titanium dioxide blended with chitosan, and polyvinyl alcohol (CS/PVA/GO/TiO2-V) patch provided a microenvironment favourable to cell growth.
[International Journal of Biological Macromolecules] |
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| Scientists illustrated the molecular mechanisms by which Forkhead box M1 (FOXM1) enhanced M2 polarization and wound healing of diabetic foot ulcer.
[Diabetes Research and Clinical Practice] |
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| Researchers demonstrated that the transcription factor SOX10 hindered immunogenicity of melanoma cells through the IRF4-IRF1 axis. Genetic and pharmacological approaches revealed that SOX10 repressed IRF1 transcription via direct induction of a negative regulator, IRF4.
[Cancer Research] |
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| The abundance of myeloid-derived suppressor cells in the tumor microenvironment was associated with therapeutic efficacy and disease outcome. Scientists analyzed the changes in the immune contexture in response to the carbon ion treatment.
[Cell Death Discovery] |
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| The authors found that 1,3-diphenyl-2-benzyl-1,3-propanedione (DPBP) had high in vitro antineoplastic activity against murine B16F10 melanoma cells and used transdermal and topical formulations of DPBP to evaluate its activity in a murine model of melanoma.
[Chemico-Biological interactions] |
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| Investigators utilized a computational approach to identify inhibitors that reversed experimentally derived B-raf proto-oncogene inhibitors (BRAFi) resistance gene expression signature and demonstrated experimentally that ibrutinib re-sensitized a subset of BRAFi-resistant melanoma cells to vemurafenib.
[Molecular Pharmacology] |
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| Scientists established a model for interleukin 1β (IL-1β)-induced dermatitis and investigated mitogen-activated protein kinase signaling pathways in IL-1β-induced interleukin 8 (IL-8) expression.
[PLoS One] |
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| Researchers studied the effect of dietary salt loading on inflammatory process and related extracellular matrix remodeling in the skin. The effect of high salt concentration on dermal fibroblasts and peripheral blood mononuclear cells was investigated in vitro.
[PLoS One] |
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| Investigators summarize the current literatures relating to the “niches” of the local skin stem cell microenvironment and the formation of skin organoids, and discuss the opportunities and challenges associated with multifunctional skin organoids.
[Frontiers in Cell and Developmental Biology] |
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| Scientists review evidence on the efficacy and safety of combined BRAF-targeted therapy and immune checkpoint inhibitors in patients with BRAF-mutated metastatic melanoma.
[Current Oncology Reports] |
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| The authors explore and propose hypotheses with respect to the possibility that rosmarinic acid can be a promising and alternative compound to be used as an adjuvant in melanoma treatment, acting on purinergic signaling.
[Purinergic Signalling] |
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| University of Queensland researchers will lead the creation of a national blueprint for screening melanoma. Professor Monika Janda will head the research team after being awarded a $5 million Synergy Grant from the National Health and Medical Research Council.
[The University of Queensland] |
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November 15 – 17, 2021
Virtual |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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| | Columbia University Medical Center – New York, New York, United States |
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| | The University of New Mexico – Albuquerque, New Mexico, United States |
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| | Novo Nordisk – Indianapolis, Indiana, United States |
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