Dermal Cell News Volume 7.40 | Nov 15 2021

    0
    102







    2021-11-15 | DCN 7.40


    Dermal Cell News by STEMCELL Technologies
    Vol. 7.40 – 15 November, 2021
    TOP STORY

    Oncostatin M Can Sensitize Sensory Neurons in Inflammatory Pruritus

    Researchers found that the cytokine oncostatin M was highly up-regulated in psoriasis, atopic dermatitis, and cutaneous T cell lymphoma, diseases associated with chronic itch.
    [Science Translational Medicine]

    Abstract
    Free Wallchart: Dynamic Modeling in Organoids
    PUBLICATIONSRanked by the impact factor of the journal

    ASC Speck Formation after Inflammasome Activation in Primary Human Keratinocytes

    Scientists showed that UVB provoked apoptosis-associated speck-like protein (ASC) speck formation in human primary keratinocytes prior to cell death, and that specks were, opposed to the perinuclear cytosolic localization in myeloid cells, formed in the nucleus.
    [Oxidative Medicine and Cellular Longevity]

    Full Article

    Enhanced Wound Healing Properties of Guar Gum/Curcumin-Stabilized Silver Nanoparticle Hydrogels

    Researchers showed that curcumin-bound silver nanoparticles exhibited low cytotoxicity and enhanced proliferation, migration, and collagen production in in vitro studies of human dermal fibroblasts.
    [Scientific Reports]

    Full Article

    Oxymatrine Promotes Hypertrophic Scar Repair through Reduced Human Scar Fibroblast Viability, Collagen and Induced Apoptosis via Autophagy Inhibition

    Investigators found that oxymatrine promoted hypertrophic scar repair by decreasing human scar fibroblast viability and collagen, and induced apoptosis via autophagy inhibition.
    [International Wound Journal]

    Abstract

    Antifibrotic Factor KLF4 Is Repressed by the miR-10/TFAP2A/TBX5 Axis in Dermal Fibroblasts: Insights from Twins Discordant for Systemic Sclerosis

    The authors used global gene expression and genome-wide DNA methylation analyses of dermal fibroblasts from a unique cohort of twins discordant for systemic sclerosis to identify molecular features of this pathology.
    [Annals of the Rheumatic Diseases]

    AbstractPress Release

    ROR2 Has a Protective Role in Melanoma by Inhibiting Akt Activity, Cell-Cycle Progression, and Proliferation

    The role of receptor tyrosine kinase-like orphan receptor 2 (ROR2) in tumor growth was assessed in xenotransplantation experiments followed by immunohistochemistry analysis of the tumors.
    [Journal of Biomedical Science]

    Full Article

    Synthesis and Characterization of a Novel pH-Responsive Drug-Releasing Nanocomposite Hydrogel for Skin Cancer Therapy and Wound Healing

    Nanocomposite hydrogel effluents were cytocompatible with human dermal fibroblasts and demonstrated pH-dependent drug release and promising therapeutic efficacy against A431 and G361 skin cancer cells in vitro.
    [Journal of Materials Chemistry B]

    Abstract

    Logical and Experimental Modeling of Cytokine and Eicosanoid Signaling in Psoriatic Keratinocytes

    Logical model simulations describing the function of cytokine and eicosanoid signaling networks combined with experimental data suggest that T-helper (Th) 17 cytokines stimulate proinflammatory cytokine expression in psoriatic keratinocytes.
    [iScience]

    AbstractGraphical Abstract

    Overexpression of miR-122 Promotes Apoptosis of Dermal Papilla Cells by Directly Targeting IGF1R in Androgenetic Alopecia

    Researchers suggested that upregulation of miR-122 induced apoptosis, potentially via the repression of insulin-like growth factor 1 receptor (IGF1R) in human dermal papilla cells of androgenetic alopecia.
    [Cell Biology International]

    Abstract
    Subscribe to Science News for free weekly science newsletters.
    REVIEWS

    Characteristics of Publicly Available Skin Cancer Image Datasets: A Systematic Review

    This is the first systematic review to characterize publicly available skin image datasets, highlighting limited applicability to real-life clinical settings and restricted population representation, precluding generalizability.
    [Lancet]

    Full Article

    DESCRIBE-AD: A Novel Classification Framework for Atopic Dermatitis

    The authors propose a novel framework to assess atopic dermatitis (AD) based on literature review and clinical experience. Rather than placing focus on any single specific aspect of AD, DESCRIBE-AD allows for a comprehensive approach to the assessment and clinical management of AD.
    [Journal of the American Academy of Dermatology]

    Abstract
    INDUSTRY AND POLICY NEWS

    Highlight Therapeutics Announces Positive Preliminary Results from Phase IIb Study of BO-112 + Anti-PD1 in Confirmed Anti-PD1 Progressor Melanoma Patients at SITC

    Highlight Therapeutics, Inc. announced positive preliminary results of a Phase II study of intratumoral administration of BO-112 with pembrolizumab in patients with advanced melanoma whose disease had progressed on first-line anti-PD1-based therapy.
    [Highlight Therapeutics, Inc.]

    Press Release

    Horizon Therapeutics plc Announces First Patient Enrolled in Phase IIb Pivotal Trial Evaluating HZN-825 for the Treatment of Diffuse Cutaneous Systemic Sclerosis

    Horizon Therapeutics plc announced the first patient has enrolled in a Phase IIb pivotal trial to evaluate its development-stage medicine HZN-825 to treat people with diffuse cutaneous systemic sclerosis, a subset of systemic sclerosis.
    [Horizon Therapeutics plc]

    Press Release
    FEATURED EVENT

    Cell Bio Virtual 2021

    December 1 – 10, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Melanoma Development

    H. Lee Moffitt Cancer Center & Research Institute – Tampa, Florida, United States

    Automation Scientist – Pluripotent Cells

    St. Jude Children’s Research Hospital – Memphis, Tennessee, United States

    Postdoctoral Fellow – Wound Healing

    The University of British Columbia – Vancouver, British Columbia, Canada

    Associate Professor – Translational Skin Cancer

    Columbia University Medical Center – New York, New York, United States

    Scientist – Endocrine Disease Specialist

    Novo Nordisk – Indianapolis, Indiana, United States

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Dermal Cell News Twitter