Dermal Cell News Volume 7.44 | Dec 13 2021

    By
    Justin.choi
    -
    0
    61







    2021-12-13 | DCN 7.44


    Dermal Cell News by STEMCELL Technologies
    Vol. 7.44 – 13 December, 2021
    TOP STORY

    Therapeutic Effect of Cyclin-Dependent Kinase 4/6 Inhibitor on Dermal Fibrosis in Murine Models of Systemic Sclerosis

    Researchers examined whether the inhibition of cell cycle with cyclin-dependent kinase (CDK) 4/6 inhibitor suppressed fibroblast proliferation and the differentiation into myofibroblasts, and the therapeutic effect of a CDK4/6 inhibitor on dermal fibrosis in murine models of systemic sclerosis.
    [Arthritis & Rheumatology]

    Abstract
    Explore tools and resources for your return to the lab
    PUBLICATIONSRanked by the impact factor of the journal

    Protective Effects of Galangin against H2O2/UVB-Induced Dermal Fibroblast Collagen Degradation via Hsa-microRNA-4535-Mediated TGFβ/Smad Signaling

    The authors investigated the mechanism underlying the protective effects of galangin against H2O2/UVB-induced damage using in vitro and in vivo models of photodamage.
    [Aging]

    Full Article

    The Deleterious Effects Induced by an Acute Exposure of Human Skin to Common Air Pollutants Are Prevented by Extracts of Deschampsia antarctica

    Investigators used a human skin organotypic culture model to characterize the deleterious effects of an acute topic exposure of human skin to moderately high concentrations of common ambient pollutants, including As, Cd, Cr, dioxins and tobacco smoke.
    [Scientific Reports]

    Full Article

    Transglutaminase 2 Mediates UVB-Induced Matrix Metalloproteinase-1 Expression by Inhibiting Nuclear p65 Degradation in Dermal Fibroblasts

    Researchers reported the role of transglutaminase 2 (TG2) in mediating the UVB-induced expression of MMP-1. UVB-irradiation enhanced the expression and activity of TG2, which in turn promoted the expression of MMP-1.
    [Experimental Dermatology]

    Abstract

    Metformin Promotes the Hair-Inductive Activity of Three-Dimensional Aggregates of Epidermal and Dermal Cells Self-Assembled In Vitro

    Scientists assessed the effect of metformin on hair growth in a mouse hair follicle reconstitution model generated by in vitro self-assembled 3D aggregates of epidermal and dermal cells and suggested that metformin could promote hair follicle regeneration.
    [Skin Pharmacology and Physiology]

    Abstract

    SOX10 Requirement for Melanoma Tumor Growth Is Due, in Part, to Immune-Mediated Effects

    SRY-box transcription factor 10 (SOX10) mediates neural crest development and is required for melanoma cell growth. The authors investigated immune-related targets of SOX10 and observed positive regulation of herpesvirus entry mediator and carcinoembryonic-antigen cell-adhesion molecule 1.
    [Cell Reports]

    Full ArticleGraphical Abstract

    NUMB as a New Therapeutic Target for Melanoma

    Scientists investigated the role of NUMB in melanoma progression and its regulatory mechanism. Analysis of The Cancer Genome Atlas melanoma datasets revealed that high NUMB expression in melanoma tissues correlated with improved patient survival.
    [Journal of Investigative Dermatology]

    Full Article

    Parvovirus B19 (B19V) Induces Cellular Senescence in Human Dermal Fibroblasts: Putative Role in SSc-Associated Fibrosis

    The authors demonstrated that B19V-infected fibroblasts developed typical senescence features such as enlarged and flat-shaped morphology and senescence-associated beta-galactosidase activity similar to that observed in systemic sclerosis (SSc) skin fibroblasts.
    [Rheumatology]

    AbstractFull Article

    Nuclear Transport Factor 2 (NTF2) Suppresses WM983B Metastatic Melanoma by Modifying Cell Migration, Metastasis, and Gene Expression

    Researchers showed that increasing NTF2 expression in WM983B metastatic melanoma cells reduced cell proliferation and motility while increasing apoptosis. They also demonstrated that increasing NTF2 expression in these cells significantly inhibited metastasis and prolonged survival of mice.
    [Scientific Reports]

    Full Article

    NF-кB c-Rel Modulates Pre-Fibrotic Changes in Human Fibroblasts

    In an in vitro model of fibrosis, investigators consistently observed the induction of the c-Rel subunit of NF-κB. Functional abrogation of c-Rel by siRNA resulted in diminished cell contractility of dermal fibroblasts in relaxed, but not in stressed 3D collagen matrices.
    [Archives of Dermatological Research]

    Full Article
    Request your free copy of the 'Directed Differentiation of Pluripotent Stem Cells' Wallchart
    REVIEWS

    Good Practice Intervention for Clinical Assessment and Diagnosis of Atopic Dermatitis: Findings from the Atopic Dermatitis Quality of Care Initiative

    The best clinical practices used by leading atopic dermatitis (AD) centers included the use of validated diagnostic criteria, established AD scoring tools including patient-reported outcome measures and electronic health records, the formation of multidisciplinary teams, and improved communication between health care providers and patients.
    [Dermatologic Therapy]

    Abstract
    INDUSTRY AND POLICY NEWS

    European Commission Approves Pfizer’s Cibinqo® (abrocitinib) for the Treatment of Adults with Moderate-to-Severe Atopic Dermatitis

    Pfizer, Inc. announced that the European Commission has approved the 100 mg and 200 mg doses of Cibinqo®, an oral, once-daily, Janus kinase 1 inhibitor, for the treatment of moderate-to-severe atopic dermatitis in adults who are candidates for systemic therapy.
    [Pfizer, Inc.]

    Press Release

    MRA Applauds Expanded Approval of Pembrolizumab to Patients with Stage 2 Melanoma

    The Melanoma Research Alliance (MRA) welcomes the US FDA decision to expand eligibility of Merck’s Keytruda to include patients with Stage IIB and IIC melanoma.
    [The Melanoma Research Alliance]

    Press Release
    FEATURED EVENT

    AACR: Precision Prevention, Early Detection, and Interception of Cancer

    January 21 -23, 2022
    Austin, Texas, United States

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Researcher – Skin Microbiome

    University Hospital of Lausanne – Lausanne, Vaud, Switzerland

    Research Fellow – RNA Surveillance

    Dana-Farber Cancer Institute – Boston, Massachusetts, United States

    Postdoctoral Position – Mechanisms of Allergic Disease

    Heidelberg University – Heidelberg, Germany

    Research Technician – Adult Mammalian Skin

    European Molecular Biology Laboratory – Heidelberg, Germany

    Postdoctoral Fellow – Melanoma Development

    H. Lee Moffitt Cancer Center & Research Institute – Tampa, Florida, United States

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Dermal Cell News Twitter