| Vol. 8.01 – 17 January, 2022 |
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| Researchers showed that the RNA-binding protein UNR/CSDE1 enabled oncogene-induced senescence in primary mouse keratinocytes. [Cell Reports] |
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PUBLICATIONSRanked by the impact factor of the journal |
| DERMAL STEM CELLS & TISSUE REGENERATION |
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| Scientists suggested that reconstructing the basement membrane promoted the secretion of platelet-derived growth factor consisting of two B subunits by epidermal keratinocytes, leading to increased collagen expression at the papillary dermis. [Scientific Reports] |
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| The authors reported that stem cells located in the bulge region of the hair follicle expressed high levels of cyclin-dependent kinase 4 through the quiescent phase of the hair cycle. [Cell Biology International] |
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| Investigators demonstrated that electrical stimulation (ES) with a polypyrrole-modified electrode upregulated trichogenic gene expression in human dermal papilla cells in vitro, and the activated cells when transplanted into mice generated double the number of hairs compared to that without the ES. [Journal of Bioscience and Bioengineering] |
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| Scientists showed that androgen receptor-mediated paracrine signaling, mainly TGF-β signaling, from dermal papilla (DP) cells induced apoptosis of microvascular endothelial cells in the DP of balding scalp of androgenetic alopecia. [Journal of Investigative Dermatology] |
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| The authors showed second generation hexameric TRAIL-receptor-agonist IZI1551 to effectively induce apoptosis in malignant melanoma cells irrespective of the intrinsic BRAF/NRAS mutation status. [Cell Death & Disease] |
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| Investigators overexpressed MYC in freshly isolated human primary melanocytes and studied the effects on melanocytic proliferation and differentiation. [Cancer Gene Therapy] |
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| Researchers found that astilbin inhibited R837-induced maturation and activation of bone marrow-derived dendritic cells and decreased the expression of pro-inflammatory cytokines by downregulating myeloid differentiation factor 88. [Journal of Cellular and Molecular Medicine] |
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| Viscoelastic measurements revealed that 2D adherent metastatic melanoma cells exhibited reduced elasticity compared to their normal counterparts — melanocytes and fibroblasts. [Communications Biology] |
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| The authors evaluated galectin (Gal)-1 and Gal-3 levels, which were beta-galactoside-binding proteins with immunomodulatory functions and examined their effects on human keratinocytes stimulated with either interleukin (IL)-4 or IL-17A. [Inflammation] |
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| Besides direct inflammatory effects at the skin barrier, microbiota may contribute to the pathogenesis of skin autoimmune diseases by metabolites, recall immune cell responses, and permeation of antigens to the subepidermal space. [Journal of Investigative Dermatology] |
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| A multi-disciplinary advisory group of Italian cutaneous squamous cell carcinoma (CSCC) experts was convened to develop criteria to assist in identifying appropriate candidates for cemiplimab therapy in advanced CSCC, based on the literature and clinical experience. [Therapeutic Advances in Medical Oncology] |
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| A cross-study comparison of the extracted studies from different databases identified 364 metabolites, whose concentrations were considerably altered by the following factor groups: irradiation, xenobiotics, aging, and skin diseases, mainly psoriasis. [Experimental Dermatology] |
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| Pfizer, Inc. announced that the US FDA approved CIBINQO® (abrocitinib), an oral, once-daily, Janus kinase 1 inhibitor, for the treatment of adults living with refractory, moderate-to-severe atopic dermatitis. [Pfizer, Inc.] |
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| Dr. Deborah Lang has been awarded a three-year, $544,390 grant from the LEO Foundation. The Lang lab and other Boston University School of Medicine collaborators, will investigate gene expression in melanocyte stem cells, and how these stem cells change into pigment-producing melanocytes. [Boston University School of Medicine] |
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| University of California Los Angeles – Los Angeles, California, United States |
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| Howard Hughes Medical Institute – Dallas, Texas, United States |
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| University Hospital of Lausanne – Lausanne, Vaud, Switzerland |
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| Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
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| Heidelberg University – Heidelberg, Germany |
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