Dermal Cell News Volume 8.01 | Jan 17 2022

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    2022-01-17 | DCN 8.01


    Dermal Cell News by STEMCELL Technologies
    Vol. 8.01 – 17 January, 2022
    TOP STORY

    Coordinated Post-Transcriptional Control of Oncogene-Induced Senescence by UNR/CSDE1

    Researchers showed that the RNA-binding protein UNR/CSDE1 enabled oncogene-induced senescence in primary mouse keratinocytes.
    [Cell Reports]

    Full ArticlePress ReleaseGraphical Abstract
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    PUBLICATIONSRanked by the impact factor of the journal

    Regeneration of Collagen Fibrils at the Papillary Dermis by Reconstructing Basement Membrane at the Dermal–Epidermal Junction

    Scientists suggested that reconstructing the basement membrane promoted the secretion of platelet-derived growth factor consisting of two B subunits by epidermal keratinocytes, leading to increased collagen expression at the papillary dermis.
    [Scientific Reports]

    Full Article

    Cyclin-Dependent Kinase 4 Expression Alters the Number of Keratinocyte Stem Cells in the Mouse Hair Follicle

    The authors reported that stem cells located in the bulge region of the hair follicle expressed high levels of cyclin-dependent kinase 4 through the quiescent phase of the hair cycle.
    [Cell Biology International]

    Abstract

    Electrical Stimulation to Human Dermal Papilla Cells for Hair Regenerative Medicine

    Investigators demonstrated that electrical stimulation (ES) with a polypyrrole-modified electrode upregulated trichogenic gene expression in human dermal papilla cells in vitro, and the activated cells when transplanted into mice generated double the number of hairs compared to that without the ES.
    [Journal of Bioscience and Bioengineering]

    Abstract

    Androgen Receptor-Mediated Paracrine Signaling Induces Regression of Blood Vessels in the Dermal Papilla in Androgenetic Alopecia

    Scientists showed that androgen receptor-mediated paracrine signaling, mainly TGF-β signaling, from dermal papilla (DP) cells induced apoptosis of microvascular endothelial cells in the DP of balding scalp of androgenetic alopecia.
    [Journal of Investigative Dermatology]

    Abstract

    Focal Adhesion Kinase Plays a Dual Role in TRAIL Resistance and Metastatic Outgrowth of Malignant Melanoma

    The authors showed second generation hexameric TRAIL-receptor-agonist IZI1551 to effectively induce apoptosis in malignant melanoma cells irrespective of the intrinsic BRAF/NRAS mutation status.
    [Cell Death & Disease]

    Full Article

    Protooncogene MYC Drives Human Melanocyte Melanogenesis and Senescence

    Investigators overexpressed MYC in freshly isolated human primary melanocytes and studied the effects on melanocytic proliferation and differentiation.
    [Cancer Gene Therapy]

    Abstract

    Topical Astilbin Ameliorates Imiquimod-Induced Psoriasis-Like Skin Lesions in SKH-1 Mice via Suppression Dendritic Cell-Th17 Inflammation Axis

    Researchers found that astilbin inhibited R837-induced maturation and activation of bone marrow-derived dendritic cells and decreased the expression of pro-inflammatory cytokines by downregulating myeloid differentiation factor 88.
    [Journal of Cellular and Molecular Medicine]

    Full Article

    Viscoelastic Parameterization of Human Skin Cells Characterize Material Behavior at Multiple Timescales

    Viscoelastic measurements revealed that 2D adherent metastatic melanoma cells exhibited reduced elasticity compared to their normal counterparts — melanocytes and fibroblasts.
    [Communications Biology]

    Full Article

    Expression Pattern and Immunoregulatory Roles of Galectin-1 and Galectin-3 in Atopic Dermatitis and Psoriasis

    The authors evaluated galectin (Gal)-1 and Gal-3 levels, which were beta-galactoside-binding proteins with immunomodulatory functions and examined their effects on human keratinocytes stimulated with either interleukin (IL)-4 or IL-17A.
    [Inflammation]

    AbstractGraphical Abstract
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    REVIEWS

    Skin Deep: The Role of the Microbiota in Cutaneous Autoimmunity

    Besides direct inflammatory effects at the skin barrier, microbiota may contribute to the pathogenesis of skin autoimmune diseases by metabolites, recall immune cell responses, and permeation of antigens to the subepidermal space.
    [Journal of Investigative Dermatology]

    Abstract

    Identifying Candidates for Immunotherapy with Cemiplimab to Treat Advanced Cutaneous Squamous Cell Carcinoma: An Expert Opinion

    A multi-disciplinary advisory group of Italian cutaneous squamous cell carcinoma (CSCC) experts was convened to develop criteria to assist in identifying appropriate candidates for cemiplimab therapy in advanced CSCC, based on the literature and clinical experience.
    [Therapeutic Advances in Medical Oncology]

    Full Article

    A Systematic Review: Metabolomics-Based Identification of Altered Metabolites and Pathways in the Skin Caused by Internal and External Factors

    A cross-study comparison of the extracted studies from different databases identified 364 metabolites, whose concentrations were considerably altered by the following factor groups: irradiation, xenobiotics, aging, and skin diseases, mainly psoriasis.
    [Experimental Dermatology]

    Abstract
    INDUSTRY AND POLICY NEWS

    US FDA Approves Pfizer’s CIBINQO® (abrocitinib) for Adults with Moderate-to-Severe Atopic Dermatitis

    Pfizer, Inc. announced that the US FDA approved CIBINQO® (abrocitinib), an oral, once-daily, Janus kinase 1 inhibitor, for the treatment of adults living with refractory, moderate-to-severe atopic dermatitis.
    [Pfizer, Inc.]

    Press Release

    Deborah Lang, PhD, Receives Grant to Provide New Insights into Stem Cell Function

    Dr. Deborah Lang has been awarded a three-year, $544,390 grant from the LEO Foundation. The Lang lab and other Boston University School of Medicine collaborators, will investigate gene expression in melanocyte stem cells, and how these stem cells change into pigment-producing melanocytes.
    [Boston University School of Medicine]

    Press Release
    FEATURED EVENT

    Nature Conference – Breaking Barriers for Gender Equity Through LEAP

    8 March, 2022
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Cutaneous Wound Healing

    University of California Los Angeles – Los Angeles, California, United States

    Research Assistant – Regenerative Medicine

    Howard Hughes Medical Institute – Dallas, Texas, United States

    Postdoctoral Researcher – Skin Microbiome

    University Hospital of Lausanne – Lausanne, Vaud, Switzerland

    Research Fellow – RNA Surveillance

    Dana-Farber Cancer Institute – Boston, Massachusetts, United States

    Postdoctoral Position – Mechanisms of Allergic Disease

    Heidelberg University – Heidelberg, Germany

    > See All Jobs

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