| Vol. 8.05 – 14 February, 2022 |
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| Scientists characterized leader cells emerging from epithelial monolayers in cell culture and found that they activated the stress sensor p53, which was sufficient to initiate leader cell behavior. [Science] |
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| PUBLICATIONSRanked by the impact factor of the journal |
| DERMAL STEM CELLS & TISSUE REGENERATION |
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| Researchers showed that LIN28B and follistatin coactivation enhanced spontaneous cochlear hair cell (HC) regeneration in neonatal mice and that LIN28B may be part of an endogenous repair mechanism that primed support cells for HC regeneration. [Science Advances] |
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| Investigators demonstrated that adult abdominal epidermal development was characterized by changes in the tissue microenvironment and a rapid exit from the cell cycle. [Current Biology] |
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| Scientists showed that collagen XVII, a niche for epidermal stem cells, helped stabilize epidermal patterns. [Laboratory Investigation] |
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| Researchers investigated the impact of CD26 deficiency in human primary fibroblasts on the regeneration of human tissue-engineered skin substitutes in vivo. [Scientific Reports] |
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| Two different humic acids were isolated from from lignite and composted artichoke wastes and characterized by infrared spectrometry, NMR spectroscopy, thermochemolysis-GC/MS, and high-performance size-exclusion chromatography. [Scientific Reports] |
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| The authors showed that the anti-fibrotic drug nintedanib was active to normalize the fibrous ECM network, enhanced the efficacy of MAPK-targeted therapy, and delayed tumor relapse in a preclinical model of melanoma. [EMBO Molecular Medicine] |
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| Researchers suggested that Mediator 1 (Med1) inhibited TGF-β signaling pathway to reduce cell epithelial-to-mesenchymal transition phenotype and migration through Smad2 ubiquitination in the metastasis of cutaneous melanoma. [Journal of Investigative Dermatology] |
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| Scientists indicated that intermittently blocking TCR signal by tacrolimus could promote anti-tumor immunity and inhibit the tumor growth in melanoma-bearing mice, inhibiting the transcription of several exhaustion-related genes, such as Nr4a1 and Ctla4. [Carcinogenesis] |
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| To explore the sebaceous glands’ possible contribution to melasma onset, the expression of pro-melanogenic and inflammatory factors from the SZ95 SG cell line exposed to single or repetitive ultraviolet A radiation was evaluated. [iScience] |
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| Downregulation of sperm-associated antigen 5 repressed malignant melanoma cell growth and epithelial to mesenchymal transition, which might be induced by inactivation of the forkhead box protein M1/A disintegrin and metalloproteinase 17/NOTCH1 signaling. [Bioengineered] |
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| The authors examine the potential role of circulating tumor DNA as a clinical tool to inform clinical decision-making from early to late stage cutaneous melanoma. [Current Oncology Reports] |
| | Investigators describe the mechanisms of immune checkpoint activation and inhibition, second, and summarize the results obtained with immune checkpoint inhibitor in melanoma treatment in terms of efficacy. [Expert Opinion On Biological Therapy] |
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| Journey Medical Corporation announced that it received notice from its exclusive licensing partner in Japan, Maruho Co., Ltd., that Japan’s Ministry of Health, Labor and Welfare approved Rapifort® Wipes 2.5% (glycopyrronium tosylate hydrate) for the treatment of primary axillary hyperhidrosis. [Journey Medical Corporation (GlobeNewswire, Inc.)] |
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| MediWound Ltd. announced that the Biomedical Advanced Research and Development Authority has expanded its awarded contract with MediWound by providing supplemental funding of $9 million to support the NexoBrid® BLA resubmission with the FDA and the ongoing expanded access treatment protocol. [MediWound Ltd.] |
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| April 7 – April 9 Rome, Italy & Virtual |
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| Imperial College London – London, England, United Kingdom |
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| University of Washington – Seattle, Washington, United States |
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| IRB Barcelona – Barcelona, Spain |
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| Wayne State University School of Medicine – Detroit, Michigan, United States |
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| University of Pennsylvania – Philadelphia, Pennsylvania, United States |
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