Dermal Cell News Volume 8.05 | Feb 14 2022

    0
    86






    2022-02-14 | DCN 8.05


    Dermal Cell News by STEMCELL Technologies
    Vol. 8.05 – 14 February, 2022
    TOP STORY

    p53 Directs Leader Cell Behavior, Migration, and Clearance during Epithelial Repair

    Scientists characterized leader cells emerging from epithelial monolayers in cell culture and found that they activated the stress sensor p53, which was sufficient to initiate leader cell behavior.
    [Science]

    AbstractPress Release
    Return to your lab safely and efficiently with these guides and resources so that you can focus more on moving your research goals forward.
    PUBLICATIONSRanked by the impact factor of the journal

    Follistatin Promotes LIN28B-Mediated Supporting Cell Reprogramming and Hair Cell Regeneration in the Murine Cochlea

    Researchers showed that LIN28B and follistatin coactivation enhanced spontaneous cochlear hair cell (HC) regeneration in neonatal mice and that LIN28B may be part of an endogenous repair mechanism that primed support cells for HC regeneration.
    [Science Advances]

    Full Article

    ECM Degradation in the Drosophila Abdominal Epidermis Initiates Tissue Growth That Ceases with Rapid Cell-Cycle Exit

    Investigators demonstrated that adult abdominal epidermal development was characterized by changes in the tissue microenvironment and a rapid exit from the cell cycle.
    [Current Biology]

    Full Article

    Collagen XVII Deficiency Alters Epidermal Patterning

    Scientists showed that collagen XVII, a niche for epidermal stem cells, helped stabilize epidermal patterns.
    [Laboratory Investigation]

    Abstract

    The Influence of CD26+ and CD26− Fibroblasts on the Regeneration of Human Dermo-Epidermal Skin Substitutes

    Researchers investigated the impact of CD26 deficiency in human primary fibroblasts on the regeneration of human tissue-engineered skin substitutes in vivo.
    [Scientific Reports]

    Full Article

    Antiflammatory Activity and Potential Dermatological Applications of Characterized Humic Acids from a Lignite and a Green Compost

    Two different humic acids were isolated from from lignite and composted artichoke wastes and characterized by infrared spectrometry, NMR spectroscopy, thermochemolysis-GC/MS, and high-performance size-exclusion chromatography.
    [Scientific Reports]

    Full Article

    Blockade of the Pro-Fibrotic Reaction Mediated by the miR-143/-145 Cluster Enhances the Responses to Targeted Therapy in Melanoma

    The authors showed that the anti-fibrotic drug nintedanib was active to normalize the fibrous ECM network, enhanced the efficacy of MAPK-targeted therapy, and delayed tumor relapse in a preclinical model of melanoma.
    [EMBO Molecular Medicine]

    Full ArticleGraphical Abstract

    Med1 Downregulation Contributes to TGF-β-Induced Metastasis by Inhibiting Smad2 Ubiquitination Degradation in Cutaneous Melanoma

    Researchers suggested that Mediator 1 (Med1) inhibited TGF-β signaling pathway to reduce cell epithelial-to-mesenchymal transition phenotype and migration through Smad2 ubiquitination in the metastasis of cutaneous melanoma.
    [Journal of Investigative Dermatology]

    Abstract

    Intermittent Administration of Tacrolimus Enhances Anti-Tumor Immunity in Melanoma-Bearing Mice

    Scientists indicated that intermittently blocking TCR signal by tacrolimus could promote anti-tumor immunity and inhibit the tumor growth in melanoma-bearing mice, inhibiting the transcription of several exhaustion-related genes, such as Nr4a1 and Ctla4.
    [Carcinogenesis]

    Abstract

    Sebocytes Contribute to Melasma Onset

    To explore the sebaceous glands’ possible contribution to melasma onset, the expression of pro-melanogenic and inflammatory factors from the SZ95 SG cell line exposed to single or repetitive ultraviolet A radiation was evaluated.
    [iScience]

    AbstractFull ArticleGraphical Abstract

    Downregulation of Sperm-Associated Antigen 5 Inhibits Melanoma Progression by Regulating Forkhead Box Protein M1/a Disintegrin and Metalloproteinase 17/NOTCH1 Signaling

    Downregulation of sperm-associated antigen 5 repressed malignant melanoma cell growth and epithelial to mesenchymal transition, which might be induced by inactivation of the forkhead box protein M1/A disintegrin and metalloproteinase 17/NOTCH1 signaling.
    [Bioengineered]

    Full ArticleGraphical Abstract
    Keep current with the latest in organoid research.
    REVIEWS

    Immune Checkpoint Inhibitors for the Treatment of Melanoma

    The authors examine the potential role of circulating tumor DNA as a clinical tool to inform clinical decision-making from early to late stage cutaneous melanoma.
    [Current Oncology Reports]

    Full Article

    Circulating Tumor DNA in Melanoma—Clinic Ready?

    Investigators describe the mechanisms of immune checkpoint activation and inhibition, second, and summarize the results obtained with immune checkpoint inhibitor in melanoma treatment in terms of efficacy.
    [Expert Opinion On Biological Therapy]

    Abstract
    INDUSTRY AND POLICY NEWS

    QBREXZA® (Rapifort® Wipes 2.5%) Receives Manufacturing and Marketing Approval in Japan Triggering $2.5 Million Milestone Payment to Journey Medical Corporation

    Journey Medical Corporation announced that it received notice from its exclusive licensing partner in Japan, Maruho Co., Ltd., that Japan’s Ministry of Health, Labor and Welfare approved Rapifort® Wipes 2.5% (glycopyrronium tosylate hydrate) for the treatment of primary axillary hyperhidrosis.
    [Journey Medical Corporation (GlobeNewswire, Inc.)]

    Press Release

    MediWound Announces Additional $9 Million in Funding from BARDA to Support NexoBrid BLA Resubmission and the Expanded Access Treatment Protocol

    MediWound Ltd. announced that the Biomedical Advanced Research and Development Authority has expanded its awarded contract with MediWound by providing supplemental funding of $9 million to support the NexoBrid® BLA resubmission with the FDA and the ongoing expanded access treatment protocol.
    [MediWound Ltd.]

    Press Release
    FEATURED EVENT

    EHA-SWG Scientific Meeting

    April 7 – April 9
    Rome, Italy & Virtual

    > See All Events

    JOB OPPORTUNITIES

    Research Associate – B Cells Immunity cSCC

    Imperial College London – London, England, United Kingdom

    Postdoctoral Positions – Translational 3D Pathology

    University of Washington – Seattle, Washington, United States

    Postdoctoral Researcher – 3D Advanced Microscopy

    IRB Barcelona – Barcelona, Spain

    Postdoctoral Research Fellow – Tumor Metabolism

    Wayne State University School of Medicine – Detroit, Michigan, United States

    Postdoctoral Fellow – Mammalian Skin Regeneration

    University of Pennsylvania – Philadelphia, Pennsylvania, United States

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Dermal Cell News Twitter