 | | Vol. 8.07 – 7 March, 2022 |
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| Investigators elucidated a mechanism whereby ΔNp63 efficiently sustained the expression of epidermal differentiation genes.
[Proceedings of the National Academy of Sciences of the United States of America] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
| | DERMAL STEM CELLS & TISSUE REGENERATION |
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| Researchers distinguished between three distinct types of melanocytes in human interfollicular epidermis: cKit+CD90–, cKit+CD90+, and cKit−CD90+.
[Cell Reports] |
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| Scientists prepared dried cultured epidermis (CE) and investigated its morphological and physical properties and wound-healing effects and compared them with those of cryopreserved CE.
[Scientific Reports] |
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| | Investigators examined how targeted therapy reprogrammed metabolism in BRAF-mutant melanoma cells using a genome-wide RNA interference screen and global gene expression profiling.
[Nature Communications] |
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| Researchers showed that CD147i, a specific inhibitor of CD147/VEGFR-2 interaction, represented a potential therapeutic strategy for NRASmut melanoma cells.
[Oncogene] |
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| Scientists demonstrated that treatment with exosomes from high glucose-pretreated immortalized human epidermal cells could delay the wound healing process in diabetic mice.
[iScience] |
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| Researchers determined the effects of antagonism of the transient receptor potential melastatin‑2 ion channel in primary human malignant melanoma cells.
[International Journal of Oncology] |
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| An in-house library of 2576 plant extracts was screened on two melanoma cell lines with different oncogenic mutations leading to pathological ERK/AKT activity.
[Journal of Natural Products] |
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| Scientists investigated the role and regulatory relationship between long noncoding RNA (lncRNA) XIST and miR-338-5p in psoriatic patients and cell models.
[Skin Pharmacology and Physiology] |
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| The authors discuss current knowledge about the functional roles of noncoding elements in skin wound healing, focusing on in vivo evidence from studies of human wound samples and animal wound models.
[Cold Spring Harbor Perspectives in Biology] |
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| Investigators summarize the state of the art on circulating microRNAs detectable in skin cancer patients including all the studies that performed microRNA identification and quantification in the circulation using appropriate sample size and statistics and provide detailed methodology.
[Expert Review of Molecular Diagnostics] |
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| Evaxion Biotech A/S finalized recruitment for Phase I/IIa clinical trial of EVX-02 in adjuvant melanoma patients.
[Evaxion Biotech A/S] |
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| Merck announced that the Phase III KEYNOTE-716 trial investigating KEYTRUDA, Merck’s anti-PD-1 therapy, as adjuvant treatment for patients with resected stage IIB and IIC melanoma met its key secondary endpoint of DMFS at a pre-specified interim analysis.
[Merck & Co., Inc.] |
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| | Technical University of Denmark – Lyngby, Denmark |
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| | King’s College London – London, England, United Kingdom |
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| | Lee Kong Chian School of Medicine – Singapore, Singapore |
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| | Durham University – Durham, England, United Kingdom |
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| | University of Pennsylvania – Philadelphia, Pennsylvania, United States |
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