Dermal Cell News Volume 8.09 | Mar 21 2022

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    2022-03-21 | DCN 8.09


    Dermal Cell News by STEMCELL Technologies
    Vol. 8.09 – 21 March, 2022
    TOP STORY

    Intermittent Treatment of BRAFV600E Melanoma Cells Delays Resistance by Adaptive Resensitization to Drug Rechallenge

    Investigators showed that intermittent treatment with the BRAFV600E inhibitor, LGX818/encorafenib, suppressed growth compared with continuous treatment in human melanoma cells engineered to express BRAFV600E, p61-BRAFV600E, or MEK2C125 oncogenes.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

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    PUBLICATIONSRanked by the impact factor of the journal

    Spatial Proteomics Reveals Subcellular Reorganization in Human Keratinocytes Exposed to UVA Light

    Scientists mapped the subcellular reorganization of the proteome of human keratinocytes in response to UVA light.
    [iScience]

    AbstractGraphical Abstract

    Single-Cell RNA Sequencing Identifies a Migratory Keratinocyte Subpopulation Expressing THBS1 in Epidermal Wound Healing

    The authors found that lysophosphatidic acid induced the differentiation of a previously unsuspected keratinocyte subpopulation expressing the extracellular matrix protein, thrombospondin-1 (THBS1).
    [iScience]

    AbstractFull ArticleGraphical Abstract

    Depilatory Laser Miniaturizes Hair by Inducing Bystander Dermal Papilla Cell Necrosis through Thermal Diffusion

    Investigators explored the role of thermal diffusion in depilatory laser-induced permanent hair loss and determined whether nonpigmented cells were injured by thermal diffusion.
    [Lasers in Surgery and Medicine]

    Abstract

    UV-induced DNA Damage in Skin is Reduced by CaSR Inhibition

    Researchers investigated whether the calcium-sensing receptor (CaSR) was involved more directly in protection from UV damage in studies of human keratinocytes in primary culture and in mouse skin studied in vivo.
    [Photochemistry and Photobiology]

    Abstract

    Mechanisms Underlying Melanoma Invasion as a Consequence of MLK3 Loss

    Scientists reported the unexpected finding that cellular loss of mixed-lineage protein kinase 3 (MLK3) in melanoma cells promoted cell invasion.
    [Experimental Cell Research]

    Abstract

    CircEIF5 Contributes to Hyperproliferation and Inflammation of Keratinocytes in Psoriasis via P-NFκB and P-STAT3 Signaling Pathway

    Researchers identified that circular RNA EIF5 (circEIF5) was highly expressed in psoriasis tissues compared to the normal skin.
    [Experimental Dermatology]

    Abstract

    PP2Acα Regulates Epidermal Cell Proliferation via the EGFR/AKT/mTOR Pathway in Psoriasis-Like Skin Lesions Caused by PPP2CA Deficiency

    The authors showed that protein phosphatase 2 A catalytic subunit α isoform (PP2Acα) negatively regulated epidermal growth factor receptor (EGFR) phosphorylation and epidermal cell proliferation, and EGFR inhibitors potentially alleviated PP2Acα by inhibiting epidermal cell proliferation.
    [Experimental Dermatology]

    Abstract

    CircOAS3 Regulates Keratinocyte Proliferation and Psoriatic Inflammation by Interacting with Hsc70 via the JNK/STAT3/NF-κB Signaling Pathway

    Investigators found that circular RNA OAS3 (circOAS3) expression was significantly upregulated in both psoriatic tissues and M5-induced keratinocytes.
    [Inflammation]

    Abstract
    Dr. Kristina McBurney and Leanna Bedell discuss how you can use social media to advance your scientific career. Watch now.
    REVIEWS

    Skin Involvement in Early Diffuse Cutaneous Systemic Sclerosis: An Unmet Clinical Need

    Considerable advances have been made in predicting the extent and rate of skin-disease progression in diffuse cutaneous systemic sclerosis, including the development of techniques such as molecular analysis of skin biopsy samples.
    [Nature Reviews Rheumatology]

    Full Article
    INDUSTRY AND POLICY NEWS

    US Food and Drug Administration Approves First LAG-3-Blocking Antibody Combination, Opdualagâ„¢ (Nivolumab and Relatlimab-rmbw), as Treatment for Patients with Unresectable or Metastatic Melanoma

    Bristol Myers Squibb announced that OpdualagTM was approved by the FDA for the treatment of adult and pediatric patients 12 years of age or older with unresectable or metastatic melanoma.
    [Bristol Myers Squibb]

    Press Release

    Transformative $5 Million Gift Launches the Alopecia Areata Center of Excellence at Mount Sinai

    In an unparalleled effort to deliver outstanding comprehensive care and to employ revolutionary approaches to novel therapeutics around the skin condition alopecia areata, the Mount Sinai Health System has launched the Alopecia Areata Center of Excellence.
    [Mount Sinai Health System]

    Press Release
    FEATURED EVENT

    New Directions in Leukemia Research 2022 (NDLR)

    May 30, 2022 – June 1, 2022
    Brisbane, Queensland, Australia

    > See All Events

    JOB OPPORTUNITIES

    Staff Scientist – Human Pluripotent Stem Cells

    Wellcome Sanger Institute – Cambridge, England, United Kingdom

    Postdoctoral Research – Multimodal Omics

    Columbia University Medical Center – New York, NY, United States

    Postdoctoral Researcher – Bioengineering Human Disease Models

    Berlin Institute of Health – Berlin, Germany

    Postdoctoral Researcher – Skin Barrier Function

    Technical University of Denmark – Lyngby, Denmark

    Assistant Professor – Skin Immunology

    Lee Kong Chian School of Medicine – Singapore, Singapore

    > See All Jobs

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