Dermal Cell News Volume 8.11 | Apr 4 2022

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    2022-04-04 | DCN 8.11


    Dermal Cell News by STEMCELL Technologies
    Vol. 8.11 – 4 April, 2022
    TOP STORY

    Multifunctional Chitosan/Silver/Tannic Acid Cryogels for Hemostasis and Wound Healing

    Researchers demonstrated a multifunctional chitosan/silver/tannic acid cryogel based on an economic method to block acute hemorrhage and promote wound healing.
    [International Journal of Biological Macromolecules]

    Full Article

    Generate More Proliferative Human Keratinocytes with DermaCult â„¢
    PUBLICATIONSRanked by the impact factor of the journal

    UV-Crosslinked Electrospun Zein/PEO Fibroporous Membranes for Wound Dressing

    A 91% cell viability result in the MTT assay with human dermal fibroblast cells confirmed the noncytotoxicity of the membrane. Tripeptides produced after the thermolysin-based hydrolysis of zein caused inhibition of TGF β1 expression and thus increased fibroblast and collagen production.
    [ACS Applied Bio Materials]

    AbstractGraphical Abstract

    Proteomic Analysis of Coarse and Fine Skin Tissues of Liaoning Cashmere Goat

    The skin samples of Liaoning cashmere goats during the growing period were collected, performed tandem mass tag method, and identified 117 differentially expressed proteins in course type and fine type.
    [Functional & integrative Genomics]

    Abstract

    The Flavonoid Nobiletin Exhibits Differential Effects on Cell Viability in Keratinocytes Exposed to UVA versus UVB Radiation

    Though nobiletin limited UVB-irradiated human keratinocytes from undergoing cell death, researchers found that this enhanced survival was not associated with increased nucleotide excision repair or XPA expression. Instead, nobiletin reduced initial UV photoproduct formation and promoted a G1 cell cycle arrest.
    [Photochemistry and Photobiology]

    AbstractFull Article

    Anatomic Position Determines Oncogenic Specificity in Melanoma

    Scientist sequenced the DNA of cutaneous and acral melanomas from a large cohort of human patients and found a specific enrichment for BRAF mutations in cutaneous melanoma and enrichment for CRKL amplifications in acral melanoma.
    [Nature]

    Abstract

    S1P Defects Cause a New Entity of Cataract, Alopecia, Oral Mucosal Disorder, and Psoriasis-Like Syndrome

    The authors found that cataract, alopecia, oral mucosal disorder, and psoriasis-like syndrome was caused by an autosomal recessive defect in the mitochondrial membrane-bound transcription factor peptidase/site-1 protease (MBTPS1, S1P).
    [EMBO Molecular Medicine]

    Full Article

    Inhibition of Histone Readers Bromodomain Extra-Terminal Proteins Alleviates Skin Fibrosis in Experimental Models of Scleroderma

    Researchers determined the anti-fibrotic efficacy and potential mechanisms of bromodomain and extra-terminal domain proteins inhibition in systemic sclerosis.
    [JCI Insight]

    AbstractGraphical Abstract

    Alpha-7 Nicotinic Acetylcholine Receptor Agonist Alleviates Psoriasis-Like Inflammation through Inhibition of the STAT3 and NF-κB Signaling Pathway

    Scientists analyzed the expression of α7nAchR in human and mouse psoriatic skin tissue. In vivo, PNU-282987 or Methyllycaconitine, a specific agonist or antagonist of α7nAchR, were administered to imiquimod-induced psoriatic mouse models.
    [Cell Death Discovery]

    Full Article

    PPP6C, a Serine-Threonine Phosphatase, Regulates Melanocyte Differentiation and Contributes to Melanoma Tumorigenesis through Modulation of MITF Activity

    Researchers identified PPP6C, a serine/threonine phosphatase, as a key regulator of MITF in melanoma.
    [Scientific Reports]

    Full Article

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    REVIEWS

    Peroxisome Proliferator-Activator Receptor γ and Psoriasis, Molecular and Cellular Biochemistry

    The authors focuse on a deeper understanding of the possible role of proliferator-activated receptor γ (PPARγ) in the pathogenesis of psoriasis and the potential of PPARγ agonist to improve the treatment of psoriasis.
    [Molecular and Cellular Biochemistry]

    Abstract

    INDUSTRY AND POLICY NEWS

    MedX Health and Health Partners Announce Agreement to Launch MedX’s Teledermatology Screening Platform in the United Kingdom

    MedX Health Corp. announced a Memorandum of Understanding and the launch of a new commercialization pilot project with Health Partners Limited, a health, treatment and primary care services company in the United Kingdom.
    [MedX Health Corp.]

    Press Release

    FEATURED EVENT

    Gene Therapy Development & Manufacturing

    13 – 14 June 2022
    London, England, United Kingdom

    > See All Events

    JOB OPPORTUNITIES

    Advance Research Assistant – Cellular Generation & Phenotyping

    Wellcome Sanger Institute – Cambridge, England, United Kingdom

    Senior Biologist – Skin Diseases

    In4Derm Ltd – Dundee, Scotland, United Kingdom

    Staff Scientist – Human Pluripotent Stem Cells

    Wellcome Sanger Institute – Cambridge, England, United Kingdom

    Clinical Professor – Clinical Oncology

    University of Southern Denmark – Odense M, Denmark

    Postdoctoral Research – Multimodal Omics

    Columbia University Medical Center – New York City, New York, United States

    > See All Jobs

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