Dermal Cell News Volume 8.17 | May 16 2022

May 16, 2022

2022-05-16 | DCN 8.17

Dermal Cell News by STEMCELL Technologies

Vol. 8.17 – 16 May, 2022

TOP STORY

Timely Wound Healing Is Dependent upon Endothelial but Not Hair Follicle Stem Cell Toll-Like Receptor 2 Signaling

Researchers used two tissue-specific conditional Toll-like receptor 2 (TLR2) knockout mouse lines to address the impact of TLR2 in endothelial and hair follicle stem cells on cutaneous wound healing.
[Journal of Investigative Dermatology]

Abstract

PUBLICATIONSRanked by the impact factor of the journal

DERMAL STEM CELLS & TISSUE REGENERATION

Merkel Cell Polyomavirus Large T Antigen Binding to pRb Promotes Skin Hyperplasia and Tumor Development

Scientists found that large T (LT)-retinoblastoma protein (pRb) interaction promoted hyperplasia, proliferation, and tumor development in the skin of transgenic mice expressing the MCPyV LT and small T antigens.
[PLoS Pathogens]

Abstract

Urolithin a Protects Human Dermal Fibroblasts from UVA-Induced Photoaging through NRF2 Activation and Mitophagy

The authors proved that urolithin A restored mitochondrial function by induction of mitophagy, which was regulated by the SIRT3-FOXO3-PINK1-PARKIN network.
[Journal of Photochemistry and Photobiology B-Biology]

Abstract

Dexamethasone, a Synthetic Glucocorticoid, Induces the Activity of Androgen Receptor in Human Dermal Papilla Cells

Researchers investigated whether the treatment of dermal papilla cells with dexamethasone, a synthetic glucocorticoids, caused the translocation of the glucocorticoid receptor into the nucleus.
[Skin Pharmacology and Physiology]

Abstract Full Article

Transdermal Permeation of Inorganic Cerium Salts in Intact Human Skin

Scientists investigated the percutaneous absorption of three inorganic Cerium (Ce) salts: cerium (III) chloride; cerium (III) nitrate and ammonium cerium (IV) nitrate, which are commonly adopted for the synthesis of CeO₂ using in vitro–ex vivo technique in Franz diffusion cells.
[Toxicology in Vitro]

Abstract Graphical Abstract

Human Dermal Microvascular Endothelial Cell Morphological Response to Fluid Shear Stress

The authors characterized the morphological response of human dermal microvascular endothelial cells and nuclei to steady, laminar, and unidirectional fluid shear stress.
[Microvascular Research]

Abstract

**Effect of a Hyaluronic Acid Based Mesotherapeutic Injectable on the Gene Expression of CLOCK and Klotho Proteins, and Environmentally Induced Oxidative Stress in Human Skin Cells**

Researchers reported that hyaluronic acid homeostasis exhibited a different profile in chronological skin ageing, as compared to environmental or extrinsic ageing
[Journal of Cosmetic Dermatology]

Abstract

SKIN CANCERS & DISORDERS

**Melanopsin (Opn4) Is an Oncogene in Cutaneous Melanoma**

Using different experimental approaches, scientists showed that melanoma cell proliferation was slower in the absence of Opn4, compared to Opn4^WT due to an impaired cell cycle progression and reduced melanocyte inducing transcription factor expression.
[Communications Biology]

Full Article

Arginyl-tRNA-Protein Transferase 1 (ATE1) Promotes Melanoma Cell Growth and Migration

Researchers reported that ATE1 was overexpressed in NRAS-mutant melanomas, while it was downregulated in BRAF-mutant melanomas.
[Febs Letters]

Abstract

**Evaluation of Anti-Proliferative Activity of Eryngium caucasicum on Melanoma Cancer Cells**

The antiproliferative activity of Eryngium caucasicum on melanoma cancer cells and non-cancerous cells were evaluated in vitro.
[BMC Complementary and Alternative Medicine]

Full Article

REVIEWS

Understanding Human Epidermal Stem Cells at Single-Cell Resolution

Using clonal growth assays of cultured keratinocytes as a quantitative measure of their abundance, the authors describe several candidate stem cell markers have been described.
[Journal of Investigative Dermatology]

Full Article

INDUSTRY AND POLICY NEWS

MediWound Announces Positive Results from Its US Phase II Trial of EscharEx for Debridement of Chronic Wounds

MediWound Ltd. announced positive results from its US Phase II clinical study of EscharEx^® for the debridement of venous leg ulcers.
[MediWound Ltd.]

Press Release

FEATURED EVENT

Dermal Cell News Volume 8.17 | May 16 2022

Timely Wound Healing Is Dependent upon Endothelial but Not Hair Follicle Stem Cell Toll-Like Receptor 2 Signaling

Merkel Cell Polyomavirus Large T Antigen Binding to pRb Promotes Skin Hyperplasia and Tumor Development

Urolithin a Protects Human Dermal Fibroblasts from UVA-Induced Photoaging through NRF2 Activation and Mitophagy

Dexamethasone, a Synthetic Glucocorticoid, Induces the Activity of Androgen Receptor in Human Dermal Papilla Cells

Transdermal Permeation of Inorganic Cerium Salts in Intact Human Skin

Human Dermal Microvascular Endothelial Cell Morphological Response to Fluid Shear Stress

**Effect of a Hyaluronic Acid Based Mesotherapeutic Injectable on the Gene Expression of CLOCK and Klotho Proteins, and Environmentally Induced Oxidative Stress in Human Skin Cells**

**Melanopsin (Opn4) Is an Oncogene in Cutaneous Melanoma**

Arginyl-tRNA-Protein Transferase 1 (ATE1) Promotes Melanoma Cell Growth and Migration

**Evaluation of Anti-Proliferative Activity of Eryngium caucasicum on Melanoma Cancer Cells**

Understanding Human Epidermal Stem Cells at Single-Cell Resolution

MediWound Announces Positive Results from Its US Phase II Trial of EscharEx for Debridement of Chronic Wounds

Gene Therapy Development & Manufacturing

> See All Events

PhD Position – Multiscale Modeling

Postdoctoral Researcher – Molecular Tissue/Organ Regeneration

Postdoctoral Fellows – Molecular Cardiology

Senior Research Technician – Skin Stem Cell Lab

Research Technician I-II – Skin Stem Cell Lab

> See All Jobs