 | | Vol. 6.09 – 15 March, 2021 |
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| Single cell RNA sequencing of neonatal human and mouse lung was used to identify the heterogeneity of pulmonary endothelial progenitor cells (EPCs). CRISPR/Cas9 gene editing was used to genetically label and purify mouse pulmonary EPCs.
[American Journal of Respiratory and Critical Care Medicine] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators observed improved cardiac function, enhanced vascular density, and smaller infarct size in mice treated with the small extracellular vesicles from hypoxia-preconditioned mesenchymal stem cells (MSCs) than in mice treated with normoxia-preconditioned MSCs.
[Science Translational Medicine] |
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| To study endothelial-to-mesenchymal transition (EndMT) in vitro, primary endothelial cells were treated with transforming growth factor-β2 and interleukin-1β. Single-cell and bulk RNA-sequencing were performed to investigate the transcriptional architecture of EndMT and identify regulated lncRNAs.
[Circulation Research] |
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| Investigators developed a bioprinting strategy to engineer prevascularized tissues in vitro and to investigate the capacity of such constructs to enhance the vascularization and regeneration of large bone defects in vivo.
[Acta Biomaterialia] |
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| Peripheral blood mononuclear cells were isolated from age-matched control subjects and end-stage renal disease patients, followed by culture in either conventional endothelial progenitor cell culture for one month or in quality and quantity culture for seven days, respectively.
[Stem Cell Research] |
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| Researchers describe the molecular processes underlying endothelial dysfunction in the development of the chronic thromboembolic pulmonary hypertension.
[Scientific Reports] |
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| Melanoma cell proliferation rates and lymph and blood microvessel densities were significantly higher in the apelin-overexpressing pulmonary metastases.
[Scientific Reports] |
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| Xanthorrhizol inhibited the phosphorylation of Akt and endothelial nitric oxide synthase and the expression of vascular cell adhesion molecule-1 and E-selectin in VEGF-treated HUVECs.
[American Journal of Chinese Medicine] |
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| A co-culture model of HUVECs and dermal mesenchymal stem cells were used in this study. After seven-day co-culture, changes in expression levels of VEGF mRNA and protein in HUVECs were assessed using RT-PCR and Western Blotting, respectively.
[Microvascular Research] |
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| Scientists give an overview of the physiological and pathological functions of endothelial cells along with proof-of-concept in vitro studies. The pathophysiology of COVID-19-associated thrombosis is also discussed.
[Critical Care] |
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| The authors give an overview of recent findings with respect to the promising potential of mesenchymal stem cells (MSCs) in cancer therapy and had an emphasis on implementing MSCs to improve them against the suppression of angiogenesis in tumor tissue, hence, impeding the tumor progression.
[Cancer Cell International] |
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| Longeveron, Inc. announced that the company has expanded and amended its exclusive license agreement related to Lomecel-B technology rights, and entered into a Collaborative Research and Development Agreement (CRADA) with the University of Miami.
[Longeveron, Inc.] |
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| AVEO Oncology announced that it has entered into a clinical trial collaboration and supply agreement with Bristol Myers Squibb to evaluate FOTIVDA® in combination with OPDIVO®, Bristol Myers Squibb’s anti-PD-1 therapy, in the pivotal Phase III TiNivo-2 trial in patients with advanced relapsed or refractory renal cell carcinoma following prior immunotherapy exposure.
[AVEO Oncology] |
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| The National Heart, Lung, and Blood Institute recently awarded Jonathan H. Jaggar, PhD, Maury Bronstein Endowed Professor in the Department of Physiology at the University of Tennessee Health Science Center a $2.3 million grant for his study titled “PKD proteins in endothelial cells.” The proposal’s goal is to provide a new understanding of how endothelial cells regulate blood pressure.
[University of Tennessee] |
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| | University of Hong Kong – Hong Kong, China |
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| | Imperial College London – London, England, United Kingdom |
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| | Albert Einstein College of Medicine – Bronx, New York, United States |
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| | Karolinska Institutet – Stockholm, Sweden |
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| | CyberCoders – San Diego, California, United States |
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
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Hepatic Cell News
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Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
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Neural Cell News
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