Identification of IL-23p19 as an Endothelial Proinflammatory Peptide that Promotes gp130-STAT3 Signaling The authors found that intercellular interleukin-23 (IL-23)p19 increased the cell surface abundances of intercellular adhesion molecule–1 and vascular cell adhesion molecule–1 on endothelial cells, which enhanced the attachment of leukocytes and increased their transendothelial migration. [Sci Signal] Abstract | Editorial Loss of Reelin Protects against Atherosclerosis by Reducing Leukocyte–Endothelial Cell Adhesion and Lesion Macrophage Accumulation In cultured human endothelial cells, Reelin enhanced monocyte adhesion and increased intercellular adhesion molecule–1, vascular cell adhesion molecule–1, and E-selectin expression by suppressing endothelial nitric oxide synthase activity and increasing nuclear factor κB activity in an apolipoprotein E receptor 2-dependent manner. [Sci Signal] Abstract | Editorial N-Acetylgalactosamine Glycans Function in Cancer Cell Adhesion to Endothelial Cells: A Role for Truncated O-Glycans in Metastatic Mechanisms The authors provide evidence of a functional role for aberrant N-acetylgalactosamine-glycans in cancer cell capture from blood flow and/or adhesion to endothelium. Adhesion of breast cancer cells to human umbilical vein endothelial cell monolayers was modeled under sweeping flow. [Cancer Lett] Abstract Roles of Endothelial A-Type Lamins in Migration of T Cells on and under Endothelial Layers Researchers altered nuclear stiffness of endothelial cells (ECs) by reducing the expression of A-type lamins using siRNA, and investigated the migration of T cells on and under EC layers. [Sci Rep] Full Article Estrogen Enhances Linkage in the Vascular Endothelial Calmodulin Network via a Feedforward Mechanism at the G Protein-Coupled Estrogen Receptor 1 Investigators showed that 17-β-estradiol upregulates total calmodulin (CaM) level in endothelial cells. Concurrent measurement of Ca2+ and Ca2+-CaM indicated that 17-β-estradiol also increases free Ca2+-CaM. [J Biol Chem] Abstract | Full Article A20 Deficiency Leads to Angiogenesis of Pulmonary Artery Endothelial Cells through Stronger NF-κB Activation under Hypoxia Scientists found a transient elevation of A20 expression in the lung tissues from hypoxic rats compared with normoxic controls. This rapid enhancement was mainly detected in the endothelium, and similar results were reproduced in vitro. [J Cell Mol Med] Full Article Comparison of Growth & Function of Endothelial Progenitor Cells Cultured on Deproteinized Bovine Bone Modified with Covalently Bound Fibronectin and Bound Vascular Endothelial Growth Factor The authors assessed and compared the growth and function of endothelial progenitor cells cultured on covalently bonded vascular endothelial growth factor and covalently bonded fibronectin coating on deproteinized bovine bone (DBB), compared to non-modified DBB blocks. [Clin Oral Implants Res] Abstract Hypoxic Conditioned Medium from Mesenchymal Stem Cells Promotes Lymphangiogenesis by Regulation of Mitochondrial-Related Proteins To investigate the effects of mesenchymal stem cell-secreted factors in starved human lymphatic endothelial cells (hLEC), hLECs were treated with endothelial basal medium-2, normoxic conditioned media, or hypoxic conditioned media in vitro and in vivo. [Stem Cell Res Ther] Full Article TNF-Alpha Promotes Lymphangiogenesis and Lymphatic Metastasis of Gallbladder Cancer through the ERK1/2/AP-1/VEGF-D Pathway The role of the tumor necrosis factor-alpha (TNF-α)-vascular endothelial growth factor D (VEGF-D) axis in the tube formation of human dermal lymphatic endothelial cells was determined using a three-dimensional coculture system. The role of the TNF-α – VEGF-D axis in lymphangiogenesis and lymph node metastasis was studied via animal experiment. [BMC Cancer] Full Article PKM2 Released by Neutrophils at Wound Site Facilitates Early Wound Healing by Promoting Angiogenesis Researchers report that infiltrated/activated neutrophils at wound site release pyruvate kinase M2 (PKM2) by its secretive mechanisms during early stages of wound repair. The released extracellular PKM2 facilitates early wound healing by promoting angiogenesis at wound site. [Wound Repair Regen] Abstract | Press Release Inhibition of Wnt Inhibitory Factor 1 under Hypoxic Condition in Human Umbilical Vein Endothelial Cells Promoted Angiogenesis In Vitro Researchers investigated the function of Wnt inhibitory factor 1 on placental angiogenesis in human umbilical vein endothelial cells under hypoxic conditions. [Reprod Sci] Abstract Long Noncoding RNA Highly Upregulated in Liver Cancer Regulates the Tumor Necrosis Factor-α-Induced Apoptosis in Human Vascular Endothelial Cells Researchers demonstrated the role of long noncoding RNA highly upregulated in liver cancer (HULC) in tumor necrosis factor-α (TNF-α)-induced apoptosis. HULC expression was decreased with TNF-α treatment. [DNA Cell Biol] Abstract |