FOXF1 Maintains Endothelial Barrier Function and Prevents Edema after Lung Injury The forkhead protein FOXF1 is a key transcriptional regulator of embryonic lung development, and investigators used a conditional knockout approach to examine the role of FOXF1 in adult lung homeostasis, injury, and repair. Tamoxifen-regulated deletion of both Foxf1 alleles in endothelial cells of adult mice caused lung inflammation and edema, leading to respiratory insufficiency and death. [Sci Signal] Abstract | Press Release Analyses of Endothelial Cells and Endothelial Progenitor Cells Released Microvesicles by Using Microbead and Q-Dot Based Nanoparticle Tracking Analysis Researchers described novel methods to purify and detect microvesicles shed from endothelial cells and endothelial progenitor cells by combining microbeads with fluorescence quantum dots coupled nanoparticle tracking analysis. [Sci Rep] Full Article mTORC2 Mediates CXCL12-Induced Angiogenesis Scientists demonstrated for the first time that CXCL12 regulation of angiogenesis requires mTORC2 but not mTORC1. They found that CXCR4 signaling activates mTORC2 as indicated by phosphorylation of serine 473 on Akt and does so through a G-protein- and PI3K-dependent pathway. [Angiogenesis] Abstract Two Functionally Distinct Pools of eNOS in Endothelium Are Facilitated by Myoendothelial Junction Lipid Composition Endothelial nitric oxide synthase (eNOS) is present in the luminal side of endothelial cells (ECs) and the basal side of ECs. To test if these eNOS pools acted in sync or separately, the authors co-cultured ECs and smooth muscle cells (SMCs), then stimulated SMCs with phenylephrine. [Biochim Biophys Acta] Abstract Context-Dependent Effects of SOCS3 in Angiotensin II-Induced Vascular Dysfunction and Hypertension in Mice: Mechanisms and Role of Bone Marrow-Derived Cells Scientists investigated the importance of suppressor of cytokine signaling 3 (SOCS3) in models of angiotensin II (Ang II)-induced vascular dysfunction. They examined direct effects of Ang II on carotid arteries from SOCS3 deficient mice and wild-type littermates using organ culture, followed by testing endothelial function with acetylcholine. [Am J Physiol Heart Circ Physiol] Abstract MLC901 Favors Angiogenesis and Associated Recovery after Ischemic Stroke in Mice Scientists investigated the preventive action of a five-week pretreatment of MLC901, an herbal extract preparation derived from Chinese medicine, against the deleterious effects of ischemic stroke and its effects on angiogenesis in a model of focal ischemia in mice. [Cerebrovasc Dis] Full Article Directing and Potentiating Stem Cell-Mediated Angiogenesis and Tissue Repair by Cell Surface E-Selectin Coating The authors present a targeted nanocarrier-mediated cell delivery method by coating the surface of the cell to be delivered with dendrimer nanocarriers modified with adhesion molecules. Infused nanocarrier-coated cells reached their destination via recognition and association with the counterpart adhesion molecules highly or selectively expressed on the activated endothelium in diseased tissues. [PLoS One] Full Article Electrospun PELCL Membranes Loaded with QK Peptide for Enhancement of Vascular Endothelial Cell Growth QK, a peptide mimicking vascular endothelial growth factor, was selected as the bioactive substrate and loaded in electrospun membranes for enhancement of vascular endothelial cell growth. [J Mater Sci Mater Med] Abstract Naringenin Exerts Anti-Angiogenic Effects in Human Endothelial Cells: Involvement of ERRα/VEGF/KDR Signaling Pathway Scientists investigated the in vitro and in vivo anti-angiogenesis of naringenin (Nar). Inhibition of angiogenesis was determined in vitro by using proliferation, apoptosis, migration, and tube-formation assays in Nar-treated human endothelial cells. [Fitoterapia] Abstract Investigating Associations of Cyclooxygenase-2 Expression with Angiogenesis, Proliferation, Macrophage and T-Lymphocyte Infiltration in Canine Melanocytic Tumors Researchers investigated associations between cyclooxygenase-2 expression and angiogenesis, proliferation and the inflammatory microenvironment in canine melanocytic tumors. [Melanoma Res] Abstract Potential of mZD7349-Conjugated PLGA Nanoparticles for Selective Targeting of Vascular Cell-Adhesion Molecule-1 in Inflamed Endothelium Modified ZD7349 (mZD7349) peptide, as an antagonist for VLA-4, was used for targeting fluorescein isothiocyanate-loaded poly (DL-lactic-co-glycolic acid) nanoparticles (NPs). Rate of binding and internalization of mZD7349–NPs to activated human umbilical vein endothelial cells were compared with that of untargeted. [Microvasc Res] Abstract |