Endothelial Cell News Volume 1.13 | Jun 13 2016

TOP STORY

Lymphatic Endothelial Cells Attenuate Inflammation via Suppression of Dendritic Cell Maturation

Lymphatic endothelial cell-conditioned media potently suppress dendritic cell maturation with reduced expression of MHCII, CD40, and IL-6, and increased IL-10 and CCL2 expression. [Oncotarget] Full Article

(Ranked by impact factor of the journal)

Treatment of Diabetes Mellitus-Induced Erectile Dysfunction Using Endothelial Progenitor Cells Genetically Modified with Human Telomerase Reverse Transcriptase

Researchers used endothelial progenitor cells (EPCs) overexpressing human telomerase reverse transcriptase (hTERT) for the treatment of diabetes mellitus-induced erectile dysfunction. Rat EPCs were transfected with hTERT (EPCs-hTERT). EPCs-hTERT secreted more growth factors and demonstrated enhanced proliferation and resistance to oxidative stress. [Oncotarget] Full Article

Interaction between Platelets and Endothelial Progenitor Cells via LPA-Edg-2 Axis Is Augmented by PPAR-δ Activation

Treatment with a highly selective peroxisome proliferator – activated receptor (PPAR)-δ agonist induced proliferation of late endothelial progenitor cells and enhanced their vasculogenic potential. A search for the target molecule of PPAR-δ activation revealed endothelial differentiation gene (Edg)-2. [J Mol Cell Cardiol] Abstract

Loss of Endothelial Barrier Integrity in Mice with Conditional Ablation of Podocalyxin (Podxl) in Endothelial Cells

Podxl-deficient lung endothelial cell (EC) cultures exhibit increased permeability to dextran and macrophage transmigration. After thrombin stimulation, ECs lacking Podxl showed delayed recovery of VE-cadherin cell contacts, persistence of F-actin stress fibers, and sustained phosphorylation of the ezrin-radixin-moesin complex and activation of RhoA, suggesting a failure in endothelial barrier stabilization. [Eur J Cell Biol] Abstract

Co-Culture of Outgrowth Endothelial Cells with Human Mesenchymal Stem Cells in Silk Fibroin Hydrogels Promotes Angiogenesis

The authors investigated the ability of outgrowth endothelial cells in mono-culture or in co-culture with human bone marrow-derived mesenchymal stem cells to form capillary networks in silk fibroin hydrogels. [Biomed Mater] Abstract

MACC-1 Promotes Endothelium-Dependent Angiogenesis in Gastric Cancer by Activating TWIST1/VEGF-A Signal Pathway

Scientists investigated the role of TWIST1 and vascular endothelial growth factor A (VEGF-A) in metastasis-associated in colon cancer-1 (MACC1)-induced endothelium-dependent angiogenesis using nude mice with gastric cancer (GC) xenografts, and human umbilical vein endothelial cells that were co-cultured with conditioned media from overexpression and interference MACC1 GC cells. [PLoS One] Full Article

Poly-ADP-Ribose Polymerase Inhibition Enhances Ischemic and Diabetic Wound Healing by Promoting Angiogenesis

This study seeks a better understanding of the role of poly-ADP-ribose polymerase in ischemic and diabetic wound healing, with a specific focus on angiogenesis and vasculogenesis. [J Vasc Surg] Abstract

Microvesicles Derived from Alde-Low EPCs Support the Wound Healing Capacity of AT-MSCs

The authors demonstrated that microvesicles derived from Alde-Low endothelial progenitor cells (EPCs) possessed the ability to improve the homing ability of non-functional Alde-High EPCs, resulting in wound healing. [Biochem Biophys Res Commun] Abstract

Visfatin Attenuates the Ox-LDL-Induced Senescence of Endothelial Progenitor Cells by Upregulating SIRT1 Expression through the PI3K/Akt/ERK Pathway

Scientists examined the effects of visfatin in oxidized low-density lipoprotein (ox-LDL)-stimulated endothelial progenitor cells (EPCs) as well as the underlying mechanism responsible for these effects. They found that visfatin attenuated the ox-LDL-induced senescence of EPCs by repressing β-galactosidase expression and recovering telomerase activity. [Int J Mol Med] Abstract

Antagonist Antibodies to Vascular Endothelial Growth Factor Receptor 2 (VEGFR-2) as Anti-Angiogenic Agents

The authors introduce the concepts of physiological and pathological angiogenesis, the crucial role played by the VEGFR-2 pathway in these processes, and the various inhibitors of its activity that have entered the clinical practice. [Pharmacol Ther] Abstract

Visit our reviews page to see a complete list of reviews in the endothelial cell research field.

NIH Awards Brown $11.5M for Computational Biology Research

With a new five-year, $11.5 million grant from the National Institutes of Health, Brown University will expand its research in computational biology and launch a new Center of Biomedical Research Excellence, which will support five early career faculty members as they tackle the genomics underlying diseases such as cancer, preeclampsia and severe lung infections. [Brown University] Press Release

Froedtert & the Medical College of Wisconsin Taps Watson for Clinical Trial Matching

IBM announced Froedtert & the Medical College of Wisconsin Cancer Network will adopt Watson cognitive computing to help match cancer patients with clinical trials. The Froedtert & MCW Cancer Network is the first in Wisconsin and among the first cancer programs in the nation to use Watson for Clinical Trial Matching. [IBM] Press Release

NEW Gordon Research Conference – Notch Signaling in Development, Regeneration & Disease
July 31-August 5, 2016
Lewiston, United States

Visit our events page to see a complete list of events in the endothelial cell community.

NEW Postdoctoral Positions – Nuclear Receptors, Metabolism and Degenerative diseases (University of Texas Health Science Center at Houston)

NEW PhD Student – Endothelial Responses to Stiffening in Aging Blood Vessels (AMC Medical Research)

Postdoctoral Fellowship – Human Pluripotent Stem Cell Differentiation (Washington University School of Medicine)

Postdoctoral Positions – Lymphatic Vasculature Development (Northwestern University – Feinberg School of Medicine)

Postdoctoral Scientist – Decoding New Targets in Angiogenesis (VIB)

Postdoctoral Fellow – Skeletal Biology (Perelman School of Medicine)

Postdoctoral Positions – Modeling Vascular Development and Disease in the Zebrafish (University of Massachusetts)

PhD Position – Physiology (Uppsala University)

Fellow/Senior Fellow – Cancer Research (Australian National University)

PhD Position – Bioinformatics (VIB)

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