Endothelial Cell News Volume 1.15 | Jun 27 2016

TOP STORY

hTERT Promotes Tumor Angiogenesis by Activating VEGF via Interactions with the Sp1 Transcription Factor

Investigators demonstrated that human telomerase reverse transcriptase (hTERT) activates vascular epithelial growth factor (VEGF) gene expression through interactions with the VEGF promoter and the transcription factor Sp1. hTERT binds to Sp1 in vitro and in vivo and stimulates angiogenesis in a manner dependent on Sp1. [Nucleic Acids Res] Full Article

(Ranked by impact factor of the journal)

Long Non-Coding RNA Taurine Upregulated 1 Enhances Tumor-Induced Angiogenesis through Inhibiting MicroRNA-299 in Human Glioblastoma

Knockdown of taurine upregulated 1 remarkably suppressed tumor-induced endothelial cell proliferation, migration and tube formation as well as reducing spheroid-based angiogenesis ability in vitro, which are the critical steps for tumor angiogenesis. [Oncogene] Abstract

Glutamine Metabolism Regulates the Pluripotency Transcription Factor OCT4

Glutamine withdrawal during vascular differentiation of human embryonic stem cells generated cells with greater angiogenic capacity, thus indicating that modulating glutamine metabolism enhances the differentiation and functional maturation of cells. [Cell Rep] Full Article | Graphical Abstract | Press Release

Age-Associated Downregulation of Vasohibin-1 in Vascular Endothelial Cells

Researchers examined whether the expression of vasohibin-1 (VASH1) would be affected by aging. They passaged human umbilical vein endothelial cells (HUVECs) and observed that VASH1 was downregulated in old HUVECs. [Aging Cell] Full Article

The Anti-Angiogenic Effect and Novel Mechanisms of Action of Combretastatin A-4

Researchers revealed that combretastatin A-4 inhibited vascular endothelial growth factor-induced proliferation, migration and capillary-like tube formation of human umbilical vascular endothelial cells. [Sci Rep] Full Article

The Insect Repellent N,N-Diethyl-m-Toluamide (DEET) Induces Angiogenesis via Allosteric Modulation of the M3 Muscarinic Receptor in Endothelial Cells

Scientists demonstrated that DEET specifically stimulates endothelial cells that promote angiogenesis which increases tumor growth. DEET activates cellular processes that lead to angiogenesis including proliferation, migration and adhesion. [Sci Rep] Full Article

A Non-Canonical Role for Desmoglein-2 in Endothelial Cells: Implications for Neoangiogenesis

Researchers revealed that desmogleins is expressed by non-desmosome-forming human endothelial progenitor cells as well as their mature counterparts in human tissue from healthy individuals and cancer patients. [Angiogenesis] Full Article

Endothelial Progenitor Cells Are Differentially Impaired in ANCA-Associated Vasculitis Compared to Healthy Controls

Circulating endothelial progenitor cell (EPC) were significantly decreased in ANCA-associated vasculitis as compared to healthy controls (HC). The capacity of EPC to differentiate and proliferate was differentially impaired in patients as compared to HC. [Arthritis Res Ther] Full Article

Probucol Protects Endothelial Progenitor Cells against Oxidized Low-Density Lipoprotein via Suppression of Reactive Oxygen Species Formation In Vivo

Investigators determined if probucol could protect endothelial progenitor cells from oxidized low-density lipoprotein in vivo and investigated the potential mechanisms. [Cell Physiol Biochem] Full Article

Circulating Bone Marrow-Derived CD45⁻/CD34⁺/CD133⁺/VEGF⁺ Endothelial Progenitor Cells in Adults with Crohn’s Disease

The authors determined whether the circulating levels of endothelial progenitor cells (EPCs) are changed in the context of Crohn’s disease (CD). CD patients and healthy controls were recruited. Disease activity was assessed by CDAI. Peripheral blood mononuclear cells were isolated and EPC numbers evaluated by FACS analysis using anti-CD34, anti-VEGF receptor-2, anti-CD133, and anti-CD45 markers. [Dig Dis Sci] Abstract

Mathematical Models of Contrast-Agent Transport Kinetics for Imaging of Cancer Angiogenesis: A Review

The combination of dynamic contrast-enhanced imaging with mathematical modeling of the contrast agent kinetics enables quantitative assessment of the structural and functional changes in the microvasculature that are associated with tumor angiogenesis. The authors review quantitative imaging of angiogenesis with dynamic contrast-enhanced magnetic resonance imaging, computed tomography, and ultrasound. [IEEE Rev Biomed Eng] Abstract

Visit our reviews page to see a complete list of reviews in the endothelial cell research field.

VM BioPharma Announces First Patient Dosed in Phase III Study of Gene Therapy Candidate, VM202, in Painful Diabetic Peripheral Neuropathy

VM BioPharma announced the first patient was dosed in the recently initiated Phase III clinical study evaluating VM202, a proprietary DNA based biopharmaceutical, in patients with painful diabetic peripheral neuropathy. [VM BioPharma (PR Newswire Association LLC.)] Press Release

Cellular Dynamics and the National Eye Institute Establish a Cooperative Research and Development Agreement (CRADA) to Advance Cell Transplantation Therapy for the Treatment of Retinal Degenerative Disease Using iPSC-Derived Cells

Cellular Dynamics International, Inc. announced that it has entered into a CRADA with the National Eye Institute to conduct research to advance a cell transplantation therapy for the treatment of retinal degenerative disease using retinal pigment epithelium derived from induced pluripotent stem cells (iPSC). [Cellular Dynamics International, Inc.] Press Release

NEW ICCSCE 2016: 18^th International Conference on Cell and Stem Cell Engineering
September 15-16, 2016
Rome, Italy

Visit our events page to see a complete list of events in the endothelial cell community.

NEW Postdoctoral Fellow – Immunometabolism (Dalhousie University)

NEW Postdoctoral Position – Endothelial Cells (KULeuven)

Postdoctoral Positions – Nuclear Receptors, Metabolism and Degenerative Diseases (University of Texas Health Science Center at Houston)

PhD Student – Endothelial Responses to Stiffening in Aging Blood Vessels (AMC Medical Research)

Postdoctoral Fellowship – Human Pluripotent Stem Cell Differentiation (Washington University School of Medicine)

Postdoctoral Positions – Lymphatic Vasculature Development (Northwestern University – Feinberg School of Medicine)

Postdoctoral Scientist – Decoding New Targets in Angiogenesis (VIB)

Postdoctoral Fellow – Skeletal Biology (Perelman School of Medicine)

Postdoctoral Positions – Modeling Vascular Development and Disease in the Zebrafish (University of Massachusetts)

Fellow/Senior Fellow – Cancer Research (Australian National University)

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