Endothelial Cell News Volume 1.18 | Jul 18 2016

TOP STORY

S6K2-Mediated Regulation of TRBP as a Determinant of miRNA Expression in Human Primary Lymphatic Endothelial Cells

Researchers demonstrated that S6 kinases can phosphorylate the extended C-terminal domain of TRBP and interact with TRBP in situ in primary cells. TRBP serines 283/286 are essential for S6K-mediated TRBP phosphorylation, optimal expression of TRBP, and the S6K-TRBP interaction in human primary cells. [Nucleic Acids Res] Full Article

(Ranked by impact factor of the journal)

Tumor-Associated Lymphatic Endothelial Cells Promote Lymphatic Metastasis by Highly Expressing and Secreting SEMA4C

Tumor-associated lymphatic endothelial cells (LECs) are molecularly and functionally different from their normal counterparts. In addition to expressing high levels of membrane-bound SEMA4C, tumor-associated LECs also produced soluble SEMA4C. [Clin Cancer Res] Abstract

Novel Role for p56/Lck in Regulation of Endothelial Cell Survival and Angiogenesis

Investigators analyzed early events leading to apoptosis of human endothelial cells exposed to high-molecular-weight kininogen. The role of tyrosine–protein kinase Lck (p56/Lck) was investigated using short interfering RNA knockdown and lentivirus expression in assays of endothelial tube formation, sprouting of neovessels from murine aorta, and angiogenesis in Matrigel plugs. [FASEB J] Abstract

Exercise Training-Induced Different Improvement Profile of Endothelial Progenitor Cells Function in Mice with or without Myocardial Infarction

Bone marrow-derived endothelial progenitor cells (EPCs) were isolated at 0 day, 3 days, 1 week, 2 weeks, 4 weeks, and 8 weeks of exercise training. After 7 days cultivation, EPC functions including proliferation, adhesion, migration, and in vitro angiogenesis were measured [Int J Cardiol] Abstract

The β2-Adrenoceptor Agonist Terbutaline Stimulates Angiogenesis via Akt and ERK Signaling

The authors investigated the angiogenic capacity of the specific β2 (beta 2)-adrenoceptor agonist terbutaline on endothelial cells derived from the central nervous system, namely bEnd.3-cells. [J Cell Physiol] Abstract

Extracellular Vesicles from Vascular Endothelial Cells Promote Survival, Proliferation and Motility of Oligodendrocyte Precursor Cells

To confirm whether extracellular vesicles (EVs) derived from microvascular endothelial cells are taken up by cultured oligodendrocyte precursor cells (OPCs), the authors labeled EVs with PKH67, a fluorescent dye, and added them to OPC cultures. Many vesicular structures labeled with PKH67 were found within OPCs immediately after their addition. [PLoS One] Full Article

Taurine and Magnesium Supplementation Enhances the Function of Endothelial Progenitor Cells through Antioxidation in Healthy Men and Spontaneously Hypertensive Rats

Researchers evaluated the effects of taurine and magnesium supplementation on endothelial progenitor cell function and oxidative stress in healthy men and spontaneously hypertensive rats. [Hypertens Res] Abstract

ApoA-I Induces S1P Release from Endothelial Cells through ABCA1 and SR-BI in a Positive Feedback Manner

Scientists confirmed that apoA-I can facilitate the production and release of sphingosine-1-phosphate (S1P) by HUVECs. Furthermore, they demonstrated that ERK1/2 and SphK activation induced by apoA-I is involved in the release of S1P from HUVECs. [J Physiol Biochem] Abstract

Transplantation of IL-10-Transfected Endothelial Progenitor Cells Improves Retinal Vascular Repair via Suppressing Inflammation in Diabetic Rats

Investigators aimed to evaluate the effect of IL-10 gene transfection on endothelial progenitor cells (EPCs) under inflammatory conditions, and explore the therapeutic potential of IL-10-transfected EPC transplantation on nonproliferative diabetic retinopathy. [Graefes Arch Clin Exp Ophthalmol] Abstract

Endothelial Cell Dysfunction as a Novel Therapeutic Target in Atherosclerosis

The authors examine some of the most common associations between therapies of cardiovascular disease and the endothelium, and summarizes the direction of research that may set the stage for one or more interventions targeted to repair damaged and/or dysfunctional endothelium. [Expert Rev Cardiovasc Ther] Abstract

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Investing in Cures for Cancer: GE Poised to Lead Industrialization of Cell Therapy Industry with Acquisition of Biosafe Group SA

GE Healthcare has acquired Biosafe Group SA, a supplier of integrated cell bioprocessing systems for the rapidly growing cell therapy and regenerative medicine industry for an undisclosed sum. [GE Healthcare] Press Release

AiVita Biomedical Awarded CIRM Grant for Development of 3D-Transplantable ‘Retinas’

AiVita Biomedical announced that the California Institute for Regenerative Medicine (CIRM) has approved the company to collaborate on an early translational research awards grant for the development of stem cell-derived 3D-transplantable retinas to treat vision loss. [AiVita Biomedical] Press Release

NEW Organoids: Modeling Organ Development and Disease in 3D Culture
October 12-15, 2016
Heidelberg, Germany

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NEW Postdoctoral Position – Cardiopulmonary Molecular Biology (Hannover Medical School)

Postdoctoral Position – Vascular Biology (Boston Children’s Hospital)

Postdoctoral Fellow – Vascular Cell Signaling (LSU Health Science Center)

Postdoctoral Positions – Endothelial Cells (Instituto de Medicina Molecular)

Faculty Position – Liver Regeneration (University of Poitiers)

Postdoctoral Fellow – Immunometabolism (Dalhousie University)

Postdoctoral Position – Endothelial Cells (KULeuven)

Postdoctoral Positions – Nuclear Receptors, Metabolism and Degenerative Diseases (University of Texas Health Science Center at Houston)

PhD Student – Endothelial Responses to Stiffening in Aging Blood Vessels (AMC Medical Research)

Postdoctoral Positions – Lymphatic Vasculature Development (Northwestern University – Feinberg School of Medicine)

Postdoctoral Scientist – Decoding New Targets in Angiogenesis (VIB)

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