Endothelial Cell News Volume 1.22 | Aug 22 2016

TOP STORY

Microenvironmental Interactions between Endothelial and Lymphoma Cells — A Role for the Canonical WNT Pathway in Hodgkin Lymphoma

Scientists identified canonical WNT pathway activity as important for the mutual interactions between classical Hodgkin Lymphoma cells and endothelial cells. [Leukemia] Abstract

(Ranked by impact factor of the journal)

Long Non-Coding RNA H19 Regulates Glioma Angiogenesis and the Biological Behavior of Glioma-Associated Endothelial Cells by Inhibiting MicroRNA-29a

Researchers investigated the functional role of H19 in glioma-induced endothelial cell proliferation, migration and tube formation as well as its possible molecular mechanisms. H19 was up-regulated in microvessels from glioma tissues and glioma-associated endothelial cells cultured in glioma conditioned medium. [Cancer Lett] Abstract

Haploinsufficiency of Klippel-Trenaunay Syndrome Gene Aggf1 Inhibits Developmental and Pathological Angiogenesis by Inactivating PI3K and AKT and Disrupts Vascular Integrity by Activating VE-Cadherin

AGGF1 inhibited VE-cadherin phosphorylation, increases plasma membrane VE-cadherin in ECs and in mice, blocks vascular permeability induced by ischemia-reperfusion (IR), restores depressed cardiac function and contraction, reduces infarct sizes, cardiac fibrosis and necrosis, hemorrhages, edema, and macrophage density associated with IR. [Hum Mol Genet] Abstract

Pregnancy-Specific Glycoprotein 9 (PSG9), a Driver for Colorectal Cancer, Enhances Angiogenesis via Activation of SMAD4

Using a human umbilical vein endothelial cell tube-forming assay, scientists found that PSG9 promoted angiogenesis. The overexpression of PSG9 also increased the growth of tumor xenografts in nude mice. [Oncotarget] Full Article

Regulatory Roles of Interferon-Inducible Protein 204 on Differentiation and Vasculogenic Activity of Endothelial Progenitor Cells

Investigators showed that interferon-inducible protein 204 inhibition decreased the endothelial differentiation and vasculogenic activities of endothelial progenitor cells in vitro. [Stem Cell Res Ther] Full Article

Bromodomain and Extra-Terminal Protein Mimic JQ1 Decreases Inflammation in Human Vascular Endothelial Cells: Implications for Pulmonary Arterial Hypertension

JQ1⁺ significantly inhibited IL6 and IL8 mRNA and protein in human pulmonary microvascular endothelial cells compared with its inactive enantiomer JQ1⁻. JQ1⁺ decreased nuclear factor kappa B p65 recruitment to native IL6 and IL8 promoters. [Respirology] Abstract | Full Article

Inhibition of 5-Lipoxygenase Suppresses Vascular Endothelial Growth Factor-Induced Angiogenesis in Endothelial Cells

To explore the roles of 5-lipoxygenase (5-LOX) in angiogenesis and its potential as a therapeutic target in cancer, the effects of a newly synthesized 5-LOX inhibitor, F3, on in vitro and in vivo angiogenesis were investigated. [Biochem Biophys Res Commun] Abstract

Promotion of Adhesion and Proliferation of Endothelial Progenitor Cells on Decellularized Valves by Covalent Incorporation of RGD Peptide and VEGF

The authors investigated the biological effects of multi-signal composite material of polyethyl glycol-cross-linked decellularized valve on adhesion and proliferation of endothelial progenitor cells. [J Mater Sci Mater Med] Abstract

Human Endothelial Progenitor Cells Rescue Cortical Neurons from Oxygen-Glucose Deprivation Induced Death

The comparison between human endothelial progenitor cells and human mesenchymal progenitor cells in terms of efficacy in rescuing neurons from cell death after transitory ischemia is the aim of this study. [Neurosci Lett] Abstract

The Role of Integrins in TGFβ Activation in the Tumor Stroma

Since αv integrins activate TGFβ, they almost certainly drive TGFβ-dependent cancer progression. Scientists discuss the data that are helping to develop this hypothesis and describe the evidence that αv integrins regulate the TGFβ promotion of cancer. [Cell Tissue Res] Abstract

Visit our reviews page to see a complete list of reviews in the endothelial cell research field.

Mallinckrodt to Acquire Stratatech Corporation, a Regenerative Medicine Company Focused on Proprietary Therapeutic Human Skin Substitute Products

Mallinckrodt plc announced that it has entered into a merger agreement with Stratatech Corporation, a privately held regenerative medicine company focused on the development of unique, proprietary skin substitute products. [Mallinckrodt plc] Press Release

Pitt Cancer Institute Awarded Major Federal Grants for Early Cancer Detection

The University of Pittsburgh Cancer Institute, partnered with UPMC CancerCenter, will receive or is sharing in $15.5 million over five years from the National Cancer Institute to accelerate research into the early detection of cancer. [University of Pittsburgh] Press Release

A Tale of Two Governments: The Politician Behind Argentina’s Science Growth

Lino Barañao, the only minister to stay in power after last year’s elections, lays out his plans. [Nature News] Editorial

Spiking Genomic Databases with Misinformation Could Protect Patient Privacy

Large genomic databases are indispensable for scientists looking for genetic variations associated with diseases. But they come with privacy risks for people who contribute their DNA. A 2013 study showed that hackers could use publicly available information on the Internet to identify people from their anonymized genomic data. [Nature News] Editorial

UK Government Gives Brexit Science Funding Guarantee

British scientists say they’re relieved by a government promise to guarantee them funding for existing EU research projects, even after the country leaves the European Union. But the reassurance only partly allays concerns about Brexit’s effect on UK science. [Nature News] Editorial

Candidate Cancer Drug Suspected after Death of Three Patients at an Alternative Medicine Clinic

A new type of cancer drug developed at Johns Hopkins University in Baltimore, Maryland, but not yet tested in clinical trials may have triggered the deaths of three patients who were undergoing an alternative cancer treatment by a nonmedical practitioner in Germany. Germany has many such practitioners, and the field is loosely regulated. The public prosecutor in Germany is now investigating whether the case constitutes involuntary manslaughter. [ScienceInsider] Editorial

NEW 2016 World Cancer Congress
October 31-November 3, 2016
Paris, France

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Research Assistant – Bone and Vascular Biology (University of Oxford)

NEW Postdoctoral Fellow – Mechanisms that Regulate Vascular Functions in Physiological and Pathological Conditions (Uppsala University)

PhD Research Project – The Role of Tetraspanin Microdomains in Angiogenesis (University of Birmingham)

PhD Thesis – In Vitro Models of the Blood-Saliva Barrier (Austrian Institute of Technology GmbH)

Postdoctoral Position – Vascular Inflammation Contributes and Atherosclerosis (University of Hawaii)

Associate Professor – Immune-Endothelial Cell Interactions (University of Virginia)

Postdoctoral Position – Molecular and Cell Biology (University Hospital of Munster)

Postdoctoral Position – Cardiopulmonary Molecular Biology (Hannover Medical School)

Postdoctoral Position – Vascular Biology (Boston Children’s Hospital)

Postdoctoral Fellow – Vascular Cell Signaling (LSU Health Science Center)

Postdoctoral Position – Endothelial Cells (KULeuven)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

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