Endothelial Cell News 1.24 September 12, 2016 | |
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TOP STORYInteraction between Integrin α5 and PDE4D Regulates Endothelial Inflammatory Signaling To investigate how fibronectin modulates inflammation in arteries, scientists replaced the cytoplasmic tail of the fibronectin receptor integrin α5 with that of the collagen/laminin receptor integrin α2. This chimera suppressed inflammatory signaling in endothelial cells on fibronectin and in knock-in mice. [Nat Cell Biol] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Knockdown of wingless-type MMTV integration site family, member 5B (WNT5B) expression in oral squamous cell carcinoma sublines did not affect tumor growth but impaired lymph node metastasis and tumor lymphangiogenesis of orthotopic transplantation. Conditioned medium from WNT5B knockdown cells reduced the tube formation of lymphatic endothelial cells. [Oncogene] Abstract Investigators report the development of a robust embryonic stem cell-based vascular differentiation assay amenable to small-molecule screens to identify novel modulators of angiogenesis. In this context, RSK and TTK were identified as angiogenic modulators. Inhibition of these pathways inhibited angiogenesis in embryoid bodies and human umbilical vein endothelial cells. [Stem Cell Reports] Full Article Researchers demonstrated an important role of hemorrhagic shock in priming for LPS-induced lung endothelial cell (EC) pyroptosis. They showed that LPS through TLR4 activates Nlrp3 inflammasome in mouse lung vascular EC, and subsequently induces caspase-1 activation. [Cell Death Dis] Full Article Scientists demonstrated that the thrombospondin-1-CD47 signaling pathway is a major mechanism for driving endothelial cell senescence. CD47 deficiency in endothelial cells significantly improved their angiogenic function and attenuated their replicative senescence. [Cell Death Dis] Full Article Mycobacterium tuberculosis Exploits the Formation of New Blood Vessels for its Dissemination The authors identified 33 genes, encoding proteins involved in angiogenesis, for which the expression was significantly modified during infection, and they showed that the potent angiogenic factor VEGF is secreted by M. tuberculosis-infected macrophages, in an RD1-dependent manner. In vivo these factors promote the formation of blood vessels in murine models of the disease. [Sci Rep] Full Article Researchers investigated lung adenocarcinoma cancer cells and endothelial and pericyte vascular cells encapsulated in cell-adhesive, proteolytically-degradable poly(ethylene) glycol-based hydrogels. [Sci Rep] Full Article Human umbilical vein and porcine aortic endothelial cells were cultured in the absence of vascular endothelial growth factor (VEGF) and treated with leptin and inhibitors of Notch, VEGF receptor and leptin receptor, OB-R. In the absence of VEGF, leptin induced the expression of several components of Notch signaling pathway in endothelial cells. [Int J Biochem Cell Biol] Abstract Scientists evaluated the effects of e-cigarette aerosol extract and conventional cigarette smoke extract on human umbilical vein endothelial cells. [Toxicol Sci] Abstract Bovine aortic endothelial cells in culture were transfected with small interfering RNAs for biglycan, and the expression of other proteoglycans was examined. [J Cell Biochem] Abstract Nicotinic Acid Inhibits NLRP3 Inflammasome Activation via SIRT1 in Vascular Endothelial Cells The authors investigated the effect of nicotinic acid on the activation of NLRP3 inflammasome and the underlying mechanisms. They found that lipopolysaccharide and adenosine triphosphate triggered the activation of NLRP3 inflammasome in human umbilical vein endothelial cells. [Int Immunopharmacol] Abstract The authors determine if the low molecular weight fraction of commercial 5% human serum albumin (LMWF5A) alters endothelial cell cytoskeletal dynamics and function. To investigate this, human retinal endothelial cells were treated with LMWF5A and the acetylation of α-tubulin was determined by immunofluorescent staining and immunoblotting. [Biochem Biophys Res Commun] Abstract | Press Release | |
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REVIEWSThe authors discuss the concept of angiogenesis, molecular pathways, and angiogenic inhibitors and their specific targets and potential of natural compounds to greatly enhance the current knowledge of angiogenesis-inhibiting factors. [Tumor Biol] Abstract Visit our reviews page to see a complete list of reviews in the endothelial cell research field. | |
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SCIENCE NEWSBioLineRx Presents Final Results from Phase IIa Trial for Relapsed/Refractory AML BioLineRx Ltd. announced that the successful final results of BL-8040’s Phase IIa clinical trial in relapsed or refractory acute myeloid leukemia (AML) were presented. [Press release from BioLineRx Ltd. discussing research presented at the 4th Annual Meeting of the Society of Hematologic Oncology (SOHO), Houston] Press Release | |
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INDUSTRY NEWSAngionetics Inc. announced that the U.S. FDA Center for Biologics Evaluation and Research has cleared the Angionetics’ Generx® angiogenic gene therapy cardiac biologic product candidate for Phase III clinical study as a new, single dose, treatment for patients with myocardial ischemia and refractory angina due to advanced coronary artery disease. [Angionetics Inc. (PR Newswire Association LLC.)] Press Release VM BioPharma announced that the company has obtained Investigational New Drug approval from the Ministry of Food and Drug Safety in Korea for a Phase II clinical trial of the investigational gene therapy drug, VM202, for ischemic heart disease. [VM BioPharma (PR Newswire Association LLC.)] Press Release | |
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POLICY NEWSWorkshop on Ethics of Monkey Research Earns Cheers and Boos Depending on whom you ask, the U.S. government workshop on the state of nonhuman primate research was either a raging success or a complete fiasco. The event, held at the National Institutes of Health brought together dozens of scientists, veterinarians, and bioethicists to discuss how research on monkeys and related animals is contributing to human medicine and to review the welfare policies that surround this work. [ScienceInsider] Editorial Cancer Experts Unveil Wishlist for US Government ‘Moonshot’ Advisers to the US Cancer Moonshot Initiative have produced a wide-ranging laundry list of research targets for the project — even as its funding remains uncertain. The ten recommendations released on 7 September include the launch of a national clinical-trial network specifically targeted at therapies that harness the immune system, and the creation of a 3D cancer atlas to catalogue how a tumour interacts with neighbouring normal cells. [Nature News] Editorial US Science Agencies Face Budget Limbo Another year, another round of budget roulette for US science agencies. When Congress returns from its summer break on 6 September, it will have just three weeks to pass a new government funding bill before the 2017 budget year begins on 1 October. Policy analysts predict that lawmakers will pass a stopgap funding measure that will keep agencies’ budgets flat until the presidential election in November — and perhaps into next year. [Nature News] Editorial
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EVENTSNEW 28th European Organization for Research and Treatment of Cancer (EORTC), the National Cancer Institute (NCI) and the American Association for Cancer Research (AACR) SYMPOSIUM NEW Cell Culture & Downstream World Congress 2017 NEW World Advanced Therapies & Regenerative Medicine Congress 2017 Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Chair – Medical Biology (Masaryk University) NEW Research Fellow – MicroRNAs in Vascular Regeneration and Angiogenesis (University of Edinburgh) Postdoctoral Research Associate – Innate Immunity and Inflammation (University of Illinois) Postdoctoral Research Assistant – Bone and Vascular Biology (University of Oxford) PhD Thesis – In Vitro Models of the Blood-Saliva Barrier (Austrian Institute of Technology GmbH) Postdoctoral Position – Cardiopulmonary Molecular Biology (Hannover Medical School) Postdoctoral Position – Endothelial Cells (KULeuven) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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