Endothelial Cell News Volume 1.28 | Oct 17 2016

TOP STORY

Single- and Double-Walled Carbon Nanotubes Enhance Atherosclerogenesis by Promoting Monocyte Adhesion to Endothelial Cells and Endothelial Progenitor Cell Dysfunction

Researchers investigated the effects of pulmonary exposure to single-walled carbon nanotubes and double-walled carbon nanotubes on atherosclerogenesis using normal human aortic endothelial cells and apolipoprotein E-deficient mice, a model of human atherosclerosis. [Part Fibre Toxicol] Full Article

(Ranked by impact factor of the journal)

Engineered Basement Membranes for Regenerating the Corneal Endothelium

Investigators showed that bovine and human corneal endothelium cells form confluent monolayers on the engineered basement membrane, express ZO-1 at the cell–cell borders, and achieve a density of ≈1600 cells mm⁻² for 28 and 14 days, respectively. [Adv Healthc Mater] Abstract

Role of Mir-155 in Controlling HIF-1α Level and Promoting Endothelial Cell Maturation

The differentiation of pluripotent stem cells into endothelial cells (ECs) was induced under hypoxia. Though the angiogenic capability and angiogenesis-related autocrine/paracrine factors of the ECs were improved under hypoxia, the level of hypoxia inducible factor 1α (HIF-1α) was nonetheless found to be restricted along with the EC differentiation. [Sci Rep] Full Article

SDF-1α-Induced Dual Pairs of E-Selectin/Ligand Mediate Endothelial Progenitor Cell Homing to Critical Ischemia

The authors showed that stromal cell-derived factor-1α (SDF-1α) presented in wound tissue and released into circulation can act both locally and remotely to induce ischemic tissue endothelium and bone marrow-derived endothelial progenitor cells to express both E-selectin and its ligands. [Sci Rep] Full Article

Exosomes Derived from Hypoxic Colorectal Cancer Cells Promotes Angiogenesis through Wnt4 Induced β-Catenin Signaling in Endothelial Cells

The authors found that exosomes derived from hypoxic colorectal cancer (CRC) cells promoted the proliferation and migration of endothelial cells. Suppression of exosome secretion through RAB27a knockdown in CRC cells inhibited exosomal induced proliferation and migration of endothelial cells. [Oncol Res] Full Article

¹³C Dynamic Nuclear Polarization for Measuring Metabolic Flux in Endothelial Progenitor Cells

Researchers used hyperpolarized carbon-13 magnetic resonance spectroscopy to profile important metabolic pathways in a population of progenitor cells and to show that cell culturing in 3D scaffolds seem to block the metabolic processes that leads to cell senescence. [Exp Cell Res] Abstract

Nerve Growth Factor Is Critical Requirement for In Vitro Angiogenesis in Gastric Endothelial Cells

The authors examined the expression of nerve growth factor (NGF) and its TrkA receptor in endothelial cells isolated from gastric mucosa of rats (GMECs), the effect of NGF treatment on in vitro angiogenesis in GMECs, and the mechanisms underlying NGF’s pro-angiogenic actions. [Am J Physiol Gastrointest Liver Physiol] Abstract

C1ql1/Ctrp14 and C1ql4/Ctrp11 Promote Angiogenesis of Endothelial Cells through Activation of ERK1/2 Signal Pathway

Scientists report that the globular domain of C1ql-like (C1ql)1/Ctrp14 and C1ql4/Ctrp11 proteins directly stimulate the angiogenesis of endothelial cells. In this study, soluble C1ql1/CTRP14 and C1ql4/Ctrp11 proteins, produced in prokaryote expression system, were co-cultured with human umbilical vein endothelium cells, which phenotype is identified with von Willebrand factor antibody. [Mol Cell Biochem] Abstract

MicroRNA-195 Regulates Proliferation, Migration, Angiogenesis and Autophagy of Endothelial Progenitor Cells by Targeting GABARAPL1

The expression of miR-582, miR-195 and miR-532 under hypoxic or normoxic conditions was measured using quantitative real-time PCR analysis and the results showed that the increased fold of miR-195 was highest in human endothelial progenitor cells under hypoxic conditions. [Biosci Rep] Full Article

Foeniculum vulgare Mill. Increases Cytosolic Ca²⁺ Concentration and Inhibits Store-Operated Ca²⁺ Entry in Vascular Endothelial Cells

Investigators assessed the effects of essential oil of Foeniculum vulgare Mill. and of trans-anethole, the main component of fennel oil, on extracellular Ca²⁺-induced store-operated Ca²⁺ entry into vascular endothelial cells and their mechanisms of action. [Biomed Pharmacother] Abstract

Contribution of Pericyte Paracrine Regulation of the Endothelium to Angiogenesis

The characteristics and the function of tissue-specific pericytesis are the focus of this review. Factors involved in the cross-talk between these cell types and the opportunities afforded by micro-RNA and micro-vesicle techniques are discussed. Targeting these mechanisms in pathological conditions, in which the vessel response is altered, is considered in relation to identification of new therapies for restoring the blood flow. [Pharmacol Ther] Abstract

Visit our reviews page to see a complete list of reviews in the endothelial cell research field.

Preliminary Results from Lenvatinib + Pembrolizumab Phase Ib Clinical Study in Select Solid Tumors

Eisai Inc. announced the presentation of preliminary results of a Phase Ib clinical study of its in-house developed multiple receptor tyrosine kinase inhibitor lenvatinib in combination with the anti-PD-1 immunotherapy pembrolizumab in patients with selected solid tumors. [Press release from Eisai Inc. discussing research presented at the 2016 European Society for Medical Oncology Congress (ESMO), Copenhagen] Press Release

FDA Grants Priority Review to Genentech’s Lucentis^® (Ranibizumab Injection) Supplemental Biologics License Application for Myopic Choroidal Neovascularization

Genentech announced that the U.S. Food and Drug Administration (FDA) has accepted a supplemental Biologics License Application and granted Priority Review for Lucentis^® for the treatment of myopic choroidal neovascularization, a complication of severe near-sightedness that can lead to blindness. [Genentech] Press Release

PanOptica Reports Positive Results from Phase I/II Clinical Trial of PAN-90806, a Novel Topical Anti-VEGF Eye Drop

PanOptica, Inc. reported positive data from a Phase I/II study of PAN-90806, a topical anti-vascular endothelial growth factor (anti-VEGF) eye drop in development for the treatment of neovascular eye diseases. [PanOptica, Inc. (Business Wire, Inc.)] Press Release

Leading Scientists Clash over Sweeping UK Research Reforms

UK government plans to shake up the way the country’s research is funded are causing dissent among leading British scientists. At the Science Media Centre in London, some of the country’s most eminent researchers clashed over the draft laws, which involve bringing together several existing funding bodies — including the UK’s seven research councils — into one central funder called UK Research and Innovation. [Nature News] Editorial

Safety Concerns Blight Promising Cancer Therapy

A groundbreaking treatment that arms immune cells called T cells to battle cancer is barreling towards regulators, fueled by unprecedented clinical success and investor exuberance. [Nature News] Editorial

Grant Awards: Diversity Boost

A recruitment and retention program launched by the Howard Hughes Medical Institution in Chevy Chase, Maryland, aims to reduce barriers for women and under-represented minorities who seek academic-research careers in the life sciences. [Nature Careers] Editorial

The Many Shades of European Postdoc Funding

Finding the right grant or fellowship to fund a postdoc can be a challenge, and the situation is all the more complex in Europe, where academic systems, career prospects, and living costs vary widely among countries. [Science Careers] Editorial

NEW Stem Cells and Regenerative Medicine 2^nd International Congress
April 19-21, 2017
Mashhad, Iran

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Research Scientist – Effects of Radiation and Other Insults on Angiogenesis and the Blood Brain Barrier (Columbia University Center for Radiological Research)

NEW Postdoctoral Research Associate – Cancer Research (Weill Cornell College of Medicine)

NEW Postdoctoral Positions – Vascular and Immune Modulation in Cancer (VIB)

NEW Research Specialist/Technician – Cardiovascular Diseases (University of Illinois Chicago College of Medicine)

Postdoctoral Positions – Cell Biology (The Roskamp Institute, Inc.)

Faculty Position – Tumor Immunology (Vanderbilt University Medical Center)

Postdoctoral Associate – Cancer Research (Thomas Jefferson University)

Postdoctoral Fellow – Extracellular Vesicle [Exosome] Research in Cancer (McGill University)

Chair – Medical Biology (Masaryk University)

PhD Student – Cell Biology, Chemistry, Material Science (Max-Planck-Institute for Molecular Biomedicine)

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