Endothelial Cell News 1.31 November 7, 2016 | |
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TOP STORYCardiac Repair in Guinea Pigs with Human Engineered Heart Tissue from Induced Pluripotent Stem Cells Researchers created human engineered heart tissue strips from human induced pluripotent stem cell (hiPSC)–derived cardiomyocytes and hiPSC-derived endothelial cells. [Sci Transl Med] Abstract | Press Release | |
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PUBLICATIONS(Ranked by impact factor of the journal)The Noni Anthraquinone Damnacanthal Is a Multi-Kinase Inhibitor with Potent Anti-Angiogenic Effects A number of in vitro assays contributed to determine the specific effects of damnacanthal on each of the steps of the angiogenic process, including inhibition of tubulogenesis, endothelial cell proliferation, survival, migration and production of extracellular matrix remodeling enzyme. [Cancer Lett] Abstract The authors investigated the role of formyl peptide receptor 2 (Fpr2) on circulating angiogenic cell (CAC) mobilization and cardiac protection in myocardial infarction (MI). WKYMVm, a strong agonist for Fpr2, was administered in a murine model of acute MI, and mobilization of CACs including endothelial progenitor cells in peripheral blood was monitored. [Stem Cells] Abstract Ethanol extract of L. herba suppressed tumor-induced angiogenesis, including migration and tube formation in human umbilical vein endothelial cells and microvessel sprouting from aortic rings via decreasing the pro-angiogenic factors in tumors. [Sci Rep] Full Article Laminin-Guided Highly Efficient Endothelial Commitment from Human Pluripotent Stem Cells Using a short fragment of laminin 411, an extracellular matrix (ECM) predominantly expressed in the vascular endothelial basement membrane, researchers demonstrated that the directed switching of defined ECMs robustly yields highly-purified endothelial progenitor cells (EPCs) without cell sorting from human pluripotent stem cells in an integrin-laminin axis-dependent manner. [Sci Rep] Full Article Human hepatic stellate cells LX-2 and human umbilical vein endothelial cells were cultured with Schistosoma japonicum antigens in vitro. Fibrosis-associated genes and cell proliferation were analyzed. [Immunol Cell Biol] Abstract Using vascular endothelial growth factor-stimulated vascular endothelial cells (VECs) isolated from microvessels, venous and arterial blood vessels as in vitro angiogenic models and unstimulated VECs as a quiescent VEC model, scientists examined the expression of tissue factor, a membrane-bound receptor on the angiogenic VEC models compared with quiescent VEC controls. [Angiogenesis] Abstract Wound healing and tube formation assays provided, for the first time, in vitro evidence that HOHA-lactone induces the release from ARPE-19 cells of vascular endothelial growth factor that promotes angiogenesis by human umbilical vein endothelial cells in culture. [Chem Res Toxicol] Abstract Investigators studied intravenous transplantation of genetically modified endothelial progenitor cells over-expressing vitamin D receptor in regulating endothelial dysfunction and spontaneously arising atherosclerotic plaques of ApoE-deficient mice. [Biomed Pharmacother] Abstract | |
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REVIEWSExploring Novel Methods for Modulating Tumor Blood Vessels in Cancer Treatment The authors explore how vascular promotion strategies (which enhance blood vessel numbers and leakiness) may be optimized for combination therapies as an alternative option for cancer treatment. [Curr Biol] Abstract Redox Regulation of Transient Receptor Potential Channels in the Endothelium The authors highlight the recent literature describing in redox regulation of transient receptor potential channel activity in endothelial cells as well as the physiological importance of these pathways and implication for cardiovascular diseases. [Microcirculation] Abstract Visit our reviews page to see a complete list of reviews in the endothelial cell research field. | |
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SCIENCE NEWSBioLineRx Ltd. disclosed positive Phase IIa correlative data, as well as detailed mechanism-of-action data, for BL-8040, the company’s leading oncology platform, that will be presented. [Press release from BioLineRx Ltd. discussing research to be presented at 58th American Society of Hematology (ASH) Annual Meeting and Exhibition, San Diego] Press Release | |
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INDUSTRY NEWSamcure announced the initiation and first patient treated in a Phase I/Ib clinical study of their lead program, AMC303, in cancer patients. [amcure GmbH] Press Release Strathclyde Researchers Go to the Heart of Blood Vessels Scientists at the University of Strathclyde are developing tiny devices that capture images of signals as they travel the innermost layer of the body’s blood vessels – helping to revolutionize the understanding of vascular disease. [University of Strathclyde] Press Release | |
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POLICY NEWSHard Work, Little Reward: Nature Readers Reveal Working Hours and Research Challenges A poll answered by thousands of Nature readers suggests that nearly two-thirds have considered quitting research, and that almost 40% work more than 60 hours in a week. The fight for funding is the greatest challenge facing early-career scientists, readers said. [Nature] Editorial Twitterstorm Shows Why Scientific Evidence Matters Grammar and Twitter rarely sit happily, so it would be churlish to point out that when the Welsh MP Glyn Davies tweeted at the weekend: “Nothing more irritating than academics rubbishing the efforts of those operating at the sharp end, without facing up to the hard decisions”, he was inadvertently complaining that people at the sharp end (himself included presumably) do not confront hard decisions. [Nature] Editorial Russian Science at the Crossroads As the United States goes to the polls after an unprecedentedly vulgar election campaign, its former cold-war rival is exuding strength and confidence. Just last week, Russia cited its proud history of exploration and science in Antarctica when giving the green light to an international agreement to create a vast marine reserve in the Ross Sea. [Nature News] Editorial Tracker Flags Up Failures to Report Clinical Trials An automated tool has trawled through thousands of records on the world’s leading clinical-trials database to reveal which drug firms and academic institutions are failing to publish the results of their trials. The US Department of Health and Human Services announced tougher rules to push the researchers that it funds to publish clinical-trial designs and results. [Nature News] Editorial
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EVENTSNEW Gordon Research Conference: Stem Cells & Cancer Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESSenior Scientific Researcher – Molecular Oncology (Genentech) Cell Biologist – Pulmonary Vascular Signaling and Endothelial Cell Biology (University of Maryland) Research Fellow – Vascular Regeneration and Angiogenesis (University of Edinburgh) Postdoctoral Research Associate – Cancer Research (Weill Cornell College of Medicine) Postdoctoral Positions – Vascular and Immune Modulation in Cancer (VIB) Postdoctoral Positions – Cell Biology (The Roskamp Institute, Inc.) Faculty Position – Tumor Immunology (Vanderbilt University Medical Center) Postdoctoral Associate – Cancer Research (Thomas Jefferson University) Postdoctoral Fellow – Extracellular Vesicle [Exosome] Research in Cancer (McGill University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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