Endothelial Cell News 1.32 November 14, 2016 | |
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TOP STORYNotch Regulates BMP Responsiveness and Lateral Branching in Vessel Networks via SMAD6 Researchers showed that bone morphogenetic protein (BMP) 6 and BMP2 ligands are pro-angiogenic in vitro and in vivo, and that lateral vessel branching requires threshold levels of R-SMAD phosphorylation. Endothelial cell responsiveness to these pro-angiogenic BMP ligands is regulated by Notch status and Notch sets responsiveness by regulating a cell-intrinsic BMP inhibitor, SMAD6, which affects BMP responses upstream of target gene expression. [Nat Commun] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)The authors isolated tumor-associated lymphatic endothelial cells (T-LECs) and normal LECs (N-LECs) from clinical samples by magnetic-activated cell sorting system and proved that CXCL1 expression was elevated in T-LECs compared with N-LECs in situ and in vitro. [Cancer Lett] Abstract Endothelial SCUBE2 Interacts with VEGFR2 and Regulates VEGF-Induced Angiogenesis Researchers investigated whether SCUBE2 (signal peptide-CUB-EGF domain-containing protein 2), a peripheral membrane protein expressed in vascular endothelial cells known to bind other signaling receptors, functions as a vascular endothelial growth factor (VEGF) receptor 2 coreceptor and to verify the role of SCUBE2 in the VEGF-induced angiogenesis. [Arterioscler Thromb Vasc Biol] Abstract Scientists investigated the effects of the short pentraxin CRP on microvascular endothelial cell angiogenic function. Subcutaneously implanted collagen plugs seeded with human microvascular endothelial cells (mECs) exposed to monomeric CRP (mCRP) in mice showed formation of an extended network of microvessels both in the plug and the overlying skin tissue, while mECs exposure to pentameric native CRP induced a much milder effect. [Thromb Haemost] Abstract Scientists investigated the effect of Co2+-mediated Toll-like receptor 4 activation on human microvascular endothelial cells, focusing on the secretion of key inflammatory cytokines and expression of adhesion molecules. [Oncotarget] Full Article Investigators sought to understand how vascular endothelial growth factor (VEGF)165 influences vasodilator production via Ca2+ signaling mechanisms in human endothelial cells. They utilized human umbilical vein endothelial cells as well as intact ex vivo human umbilical vein to address direct stimulation of Ca2+ and NO by VEGF165 alone, as well as the effect of VEGF165 on subsequent ATP-stimulated Ca2+ signaling and NO production. [Am J Physiol Heart Circ Physiol] Abstract A down-regulation of microRNA-433 was identified in hypoxia-induced human umbilical vein vascular endothelial cells (HUVECs) as well as in rat neurons, and was found to be negatively regulated cell proliferation and migration. [J Mol Neurosci] Abstract The authors explored the mechanism of the protective effect of salidroside (SAL) on homocysteine (Hcy) induced endothelial dysfunction. Pretreatment of the human umbilical vein endothelial cells (HUVECs) with SAL significantly reduced the cell damage effects brought by Hcy in a dose-dependent manner. [Cardiovasc Ther] Abstract In vitro, human telomerase catalytic subunit (hTERT) transduction of endothelial progenitor cells resulted in a significantly superior proliferative capacity as well as significantly higher NO, iNOS, and LDH secretory capacity. [Cardiology] Abstract | |
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REVIEWSThe Role of CC-Chemokines in the Regulation of Angiogenesis The authors highlight the significant role of the CC-chemokine class in inflammation, versus ischemia driven angiogenesis, and discuss the related pathologies including atherosclerosis, cancer, and rheumatoid arthritis. [Int J Mol Sci] Full Article Visit our reviews page to see a complete list of reviews in the endothelial cell research field. | |
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SCIENCE NEWSCOLUMBUS Phase III Study Results in BRAF-Mutant Melanoma Presented Array BioPharma and Pierre Fabre jointly announced new results from the pivotal Phase III COLUMBUS trial of binimetinib plus encorafenib (bini/enco) treatment in BRAF-mutant melanoma patients. [Press release from Array BioPharma discussing research presented at the Society for Melanoma Research Annual Congress 2016, Boston] Press Release Biothera Pharmaceuticals, Inc. will present new preclinical data that further validate the ability of its Phase II cancer immunotherapy drug Imprime PGG to induce coordinated innate and adaptive immune responses that may enhance the efficacy of checkpoint inhibitor therapies. [Press release from Biothera Pharmaceuticals, Inc. discussing research presented at Society for Immunotherapy of Cancer (SITC) 2016, National Harbor] Press Release | |
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INDUSTRY NEWSSernova and CTI Clinical Trial Announce Regulatory Collaboration Sernova Corp. announced their collaboration on regulatory matters respecting Sernova’s Cell Pouch System, a novel implantable and scalable medical device that when combined with therapeutic cells, may provide a convenient, safe and effective long-term therapeutic option for patients with chronic diseases such as insulin-dependent diabetes who seek to improve their quality of life. [Sernova Corp.] Press Release LifeNet Health has acquired the assets of Alabama-based biotechnology company Vivo Biosciences, Inc., as part of the organization’s growing emphasis on applying cell-based innovations to the process of pharmaceutical discovery and personalized medicine. [LifeNet Health] Press Release | |
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POLICY NEWSDisgraced Stem-Cell Entrepreneur under Fresh Investigation Public prosecutors in Turin, Italy, are investigating whether disgraced stem-cell entrepreneur Davide Vannoni — convicted on criminal charges last year for administering unproven stem-cell therapies in Italy — is offering his treatments again, this time in eastern Europe. [Nature News] Editorial The Ultimate Experiment: How Trump Will Handle Science The long campaign for the White House is over — but incoming US president Donald Trump’s work is just starting. With just two months before his inauguration on 20 January, he and his staff are busy vetting candidates for top government jobs and clarifying the agenda for his first few months in office. [Nature News] Editorial Embryonic Stem Cells and Fetal Tissue Research—Will Trump Intervene? Of all the materials valued in biomedical research, embryonic stem (ES) cells and fetal tissue have gotten disproportionate attention from politicians. Because creating ES cell lines initially requires destroying a human embryo, President George W. Bush tightly restricted the use of federal funds for research on all but a few stem cell lines. President Barack Obama then made lifting those restrictions one of his first official actions after he took office in 2009. [Science Insider] Editorial NIH to Double Funding for Chronic Fatigue Syndrome, but Patient Distrust Remains NIH spending for research on the poorly understood disease should rise to roughly $15 million in 2017, doubling the estimated $7.6 million handed out in 2016. The biomedical agency will solicit CFS proposals from outside scientists to establish several collaborative centers for basic and clinical research, and another center to manage their data on the illness. The calls for applications, which will come with dedicated funds from the planned budget increase, are the first of their kind for CFS from the United States’s major medical research funder since 2005. [Science Insider] Editorial
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EVENTSNEW 19th International Conference on Clinical Application of Adult Stem Cells Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Position – Endothelial Heterogeneity (KULeuven) NEW Postdoctoral Fellow – Molecular Cardiology (Cleveland Clinic) Senior Scientific Researcher – Molecular Oncology (Genentech) Cell Biologist – Pulmonary Vascular Signaling and Endothelial Cell Biology (University of Maryland) Postdoctoral Research Associate – Cancer Research (Weill Cornell College of Medicine) Postdoctoral Positions – Vascular and Immune Modulation in Cancer (VIB) Postdoctoral Positions – Cell Biology (The Roskamp Institute, Inc.) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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