Endothelial Cell News Volume 1.36 | Dec 12 2016

TOP STORY

Tenascin-C Orchestrates Glioblastoma Angiogenesis by Modulation of Pro- and Anti-Angiogenic Signaling

Investigators examined the angiomodulatory role of tenascin-C. They found that direct contact of endothelial cells with tenascin-C disrupts actin polymerization, resulting in cytoplasmic retention of the transcriptional coactivator YAP. [Cell Rep] Full Article | Graphical Abstract

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G-Protein-Coupled Receptor-2-Interacting Protein-1 Controls Stalk Cell Fate by Inhibiting Delta-Like 4-Notch1 Signaling

The spatiotemporal localization and expression of Dll4 are critical for sprouting angiogenesis. However, the related mechanisms are poorly understood. Scientists showed that G-protein-coupled receptor-kinase interacting protein-1 is a robust endogenous inhibitor of Dll4-Notch1 signaling that specifically controls stalk cell fate. [Cell Rep] Full Article | Graphical Abstract

Adiporedoxin Suppresses Endothelial Activation via Inhibiting MAPK and NF-κB Signaling

Adiporedoxin (Adrx) is a recently discovered redox regulatory protein that is preferentially expressed in adipose tissue and plays a critical role in the regulation of metabolism via its modulation of adipocyte protein secretion. Researchers report that Adrx suppresses endothelial cell activation via inhibiting MAPK and NF-kB signaling pathways. [Sci Rep] Full Article

A Novel Bioreactor System for the Assessment of Endothelialization on Deformable Surfaces

The authors introduced the design and validation of a novel bioreactor system which enables the long-term conditioning of human endothelial cells interacting with artificial materials under dynamic combinations of flow-generated wall shear stress and wall deformation. [Sci Rep] Full Article

Metabolic Consequences of Inflammatory Disruption of the Blood-Brain Barrier in an Organ-on-Chip Model of the Human Neurovascular Unit

Researchers paired a novel dual-chamber, organ-on-chip microfluidic device, the NeuroVascular Unit, with small-volume cytokine detection and mass spectrometry analysis to investigate how the blood-brain barrier responds to two different but overlapping drivers of neuroinflammation, lipopolysaccharide and a cytokine cocktail of IL-1β, TNF-α, and MCP1,2. [J Neuroinflammation] Full Article | Press Release | Video

Modulation of VEGF Signaling in a Mouse Model of Diabetes by Xanthohumol and 8-Prenylnaringenin: Unveiling the Angiogenic Paradox and Metabolism Interplay

Xanthohumol and 8-prenylnaringenin beer polyphenols modulate angiogenesis, being thus targets for type 2 diabetes (T2DM)-related complications. Scientists examined whether polyphenols consumption affects angiogenic paradox and metabolism in a T2DM mouse model. [Mol Nutr Food Res] Abstract

H2S Inhibits Pulmonary Arterial Endothelial Cell Inflammation in Rats with Monocrotaline-Induced Pulmonary Hypertension

Investigators aimed to determine whether hydrogen sulfide (H2S) inhibits pulmonary arterial endothelial inflammation in rats with monocrotaline-induced pulmonary hypertension and its possible mechanisms. [Lab Invest] Abstract

Shock Wave Enhances Angiogenesis through VEGFR2 Activation and Recycling

The authors aimed at testing whether shock wave (SW)-induced angiogenesis may be through endothelial vascular endothelial growth factor receptor 2 (VEGFR2) signaling and trafficking. Phosphorylation of VEGFR2-Akt-eNOS axis and production of nitric oxide were determined in human umbilical vein endothelial cells treated with SW. [Mol Med] Full Article

Resveratrol Rescues Hyperglycemia-Induced Endothelial Dysfunction via Activation of Akt

Scientists aimed to investigate the signaling mechanisms underlying the protecting effects of resveratrol against endothelial dysfunction during hyperglycemia in vitro and in vivo. [Acta Pharmacol Sin] Abstract

3D Co-Culture Model to Analyze the Crosstalk between Endothelial and Smooth Muscle Cells

The authors developed and validated a modified three dimensional (3D) sandwich co-culture of endothelial cells and smooth muscle cells employing open µ-Slides with a thin glass bottom allowing direct imaging. [Tissue Eng Part C Methods] Abstract

Vascular Inter-Regulation of Inflammation: Molecular and Cellular Targets for CNS Therapy

The authors present key aspects regarding endothelial cell function and tissue remodeling that are particularly affected or aggravated by inflammation. [J Neurochem] Abstract

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Clinically Meaningful Data for Oral Nintedanib in Mesothelioma Presented

Boehringer Ingelheim announced that the LUME-Meso Phase II trial in patients with unresectable malignant pleural mesothelioma met its primary endpoint of progression-free survival (PFS). The data showed nintedanib plus pemetrexed/cisplatin demonstrated a meaningful clinical benefit compared to placebo plus pemetrexed/cisplatin, with a significantly improved PFS. Preliminary overall survival data also favored nintedanib. [Press release from Boehringer Ingelheim Pharmaceuticals, Inc. ( PR Newswire Association LLC.) discussing research presented at 17^th International Association for the Study of Lung Cancer (IASLC) World Conference on Lung Cancer, Vienna] Press Release

Novartis Provides Update on Pegpleranib Phase III Clinical Trial Program in Patients with Neovascular Age-Related Macular Degeneration (nAMD or Wet AMD)

Novartis announced initial topline results from two pivotal Phase III clinical studies evaluating the safety and efficacy of pegpleranib in combination with Lucentis^® for the treatment of neovascular age-related macular degeneration. [Novartis] Press Release

Ophthotech Announces Results from Pivotal Phase III Trials of Fovista^® in Wet Age-Related Macular Degeneration

Ophthotech Corporation announced that the pre-specified primary endpoint of mean change in visual acuity at 12 months was not achieved in its two pivotal Phase III clinical trials investigating the superiority of Fovista^® anti-PDGF therapy in combination with Lucentis^® anti-VEGF therapy compared to Lucentis^® monotherapy for the treatment of wet age-related macular degeneration. [Ophthotech Corporation] Press Release

Brexit by the Numbers: The Fear of Brain Drain

British universities fear losing large swathes of their research staff as the country faces up to Brexit, the split with the European Union. More than 31,000 academics at UK universities are non-British EU citizens, and so may lose their rights to live in the United Kingdom after Brexit. [Nature Trend Watch] Editorial

Italian Scientists Won’t Miss Departing Prime Minister Matteo Renzi

Italian politics is in turmoil after the resignation of Prime Minister Matteo Renzi — but researchers say that they are not particularly sad to see him go. In his almost three years in charge, Renzi promised improvements for universities and science but failed to raise the status of research in the country, according to scientists who complain that he also directly interfered in academic affairs. [Nature News] Editorial

NEW The Biology of Regenerative Medicine
April 25-27, 2017
Hinxton, United Kingdom

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NEW Postdoctoral Scientist – Molecular Cell Biology (Medical Research Council)

NEW Postdoctoral Fellow – Endothelial Cell Dysfunction and GPCR Signaling in Vascular Diseases (The University of Tennessee Health Science Center)

Assistant Professor – Regenerative Medicine (University of Cincinnati)

Postdoctoral Position – Endothelial Interactions in Vascular Disease (University of Pittsburgh)

Postdoctoral Position – Intersectional Genetics (VIB)

Postdoctoral Associate – Neuroscience (University of Pittsburgh)

Postdoctoral Fellow – Vascular Cell Signaling (Louisiana State University Health Sciences Center)

Postdoctoral Fellowship – Vascular Biology and Genetics (Boston Children’s Hospital and Harvard Medical School)

Research Associate – Molecular Mechanisms underlying Abnormal Human Placental Vascular Function (University of Colorado Anschutz Medical Campus)

Senior Scientific Researcher – Molecular Oncology (Genentech)

Cell Biologist – Pulmonary Vascular Signaling and Endothelial Cell Biology (University of Maryland)

Postdoctoral Positions – Vascular and Immune Modulation in Cancer (VIB)

Research Specialist/Technician – Cardiovascular Diseases (University of Illinois Chicago College of Medicine)

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