Endothelial Cell News 2.26 July 31, 2017 | |
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TOP STORYGenome-wide association studies implicated the PHACTR1 locus in risk for five vascular diseases, including coronary artery disease, migraine headache, cervical artery dissection, fibromuscular dysplasia, and hypertension. Through genetic fine mapping, scientists prioritized rs9349379, a common SNP in the third intron of the PHACTR1 gene, as the putative causal variant. [Cell] Abstract | Press Release | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Genome Editing Abrogates Angiogenesis In Vivo The authors report that a system of adeno-associated virus-mediated clustered regularly interspaced short palindromic repeats-associated endonuclease (Cas) 9 from Streptococcus pyogenes (SpCas9) was used to deplete VEGF receptor 2 in vascular endothelial cells, whereby the expression of SpCas9 was driven by an endothelial-specific promoter of intercellular adhesion molecule 2. [Nat Commun] Full Article | Press Release Researchers determined the exact frequency of arterial occlusive disease (AOD) and examined the in vitro and in vivo effects of Nilotinib and Imatinib on endothelial cells to explain AOD-development. In contrast to Imatinib, Nilotinib was found to upregulate pro-atherogenic adhesion-proteins on human endothelial cells. [Leukemia] Abstract Investigators showed that hypoxia lowered the expression of adenosine kinase (ADK) and increased the levels of intracellular adenosine in human endothelial cells. Knockdown of ADK elevated intracellular adenosine, promoted proliferation, migration, and angiogenic sprouting in human endothelial cells. [EMBO Mol Med] Full Article Intracrine VEGF Signaling Mediates Colorectal Cancer Cell Migration and Invasion Since extracellular VEGF signaling regulates migration of endothelial cells and various tumor cells, researchers attempted to determine whether intracrine VEGF signaling affects colorectal cancer (CRC) cell motility. Depletion of intracellular VEGF and VEGFR1 in multiple CRC cell lines led to strong inhibition of migration and invasion of CRC cells. [Br J Cancer] Abstract Scientists identified tannic acid (TA), a polyphenolic compound, as a potent Kruppel-like factor 2 (KLF2) activator that attenuates endothelial inflammation. Mechanistic studies suggested that TA induced KLF2 expression in part through the ERK5/MEF2 pathway. [Sci Rep] Full Article Gap Junction-Mediated Regulation of Endothelial Cellular Stiffness Researchers studied the role of gap junctions in the regulation of endothelial stiffness, an important physical feature that is associated with many vascular pathologies. They found that tumor necrosis factor-α transiently increased endothelial cellular stiffness, which was regulated by cytoskeletal rearrangement and cell-cell interactions. [Sci Rep] Full Article Establishment and Long-Term Culture of Human Cystic Fibrosis Endothelial Cells To obtain virtually pure pulmonary artery endothelial cells (PAEC), the authors developed an easy, inexpensive, and reliable method, based on the differential adhesion time of pulmonary artery cells collected after collagenase digestion. With this method, they obtained up to 95% pure non-cystic fibrosis (CF) and CF-PAEC. [Lab Invest] Abstract Scientists developed a direct contact co-culture approach compatible with highly labile effectors, such as nitric oxide (NO), and applied it for determining the effect of endothelial cell functionalization via NO synthase gene transfer on the growth of co-cultured arterial smooth muscle cells exhibiting the defining characteristics of neointimal cells. [Drug Deliv Transl Res] Abstract | |
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REVIEWSAnimal Models of Ocular Angiogenesis: From Development to Pathologies The authors summarize the current available animal models of ocular angiogenesis. Theoretical concepts and experimental protocols of these models are outlined, as well as their advantages and potential limitations. [FASEB J] Abstract Role of Free Fatty Acids in Endothelial Dysfunction Investigators summarize the roles and the underlying mechanisms, using the evidence collected from clinical and experimental studies, about free fatty acid-mediated endothelial dysfunction. [J Biomed Sci] Full Article Visit our reviews page to see a complete list of reviews in the endothelial cell research field. | |
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INDUSTRY NEWSThe St. Baldrick’s Foundation awarded 90 new grants totaling $23.5 million in its summer grant cycle to support the brightest minds in the pediatric cancer field. [St. Baldrick’s Foundation] Press Release Aerie Pharmaceuticals, Inc. announced that it has entered into a collaborative research, development and license agreement with DSM. [Aerie Pharmaceuticals, Inc.] Press Release Santen Pharmaceutical Co. Ltd. and TRACON Pharmaceuticals, Inc. announced that Santen has initiated a Phase IIa clinical study of DE-122 in patients with wet age-related macular degeneration. [Santen Pharmaceutical Co.] Press Release | |
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POLICY NEWSAt Harvard, Extraordinary Court Battle between Ph.D. Student and Prominent Researcher Grinds On The conflict between Gustavo German, a Harvard doctoral student in biomedicine, and Lee Rubin, a prominent stem cell researcher, has continued to evolve. Amid continued legal jousting, the situation has remained difficult for all of the parties involved in this tumultuous episode. [ScienceInsider] Editorial First Human Embryos Edited in U.S. The first known attempt at creating genetically modified human embryos in the United States has been carried out. The effort involved changing the DNA of a large number of one-cell embryos with the gene-editing technique CRISPR. [MIT Technology Review] Editorial Ding, Ding, Ding! CRISPR Patent Fight Enters Next Round The University of California has fired another legal salvo in the prolonged patent battle over CRISPR, the revolutionary gene-editing technology that has spawned a billion dollar industry. [ScienceInsider] Editorial
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EVENTSNEW European Society for Medical Oncology (ESMO) 2018 Congress Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Fellow – Structural Biology (Karolinska Institutet) NEW Tenure-Track Faculty Scientist (Temple University) NEW Postdoctoral Fellow – Mechanobiology of Tissue Repair (St. Michael’s Hospital) NEW Assistant Professor – Stem Cell and Regenerative Medicine (Harvard University) NEW Postdoctoral Research Scientist – Tissue Repair (The University of Alabama) Postdoctoral Research Scientist – Drug Discovery and Cell Therapy (Inserm) Assistant Professor – Vascular and Microvascular Biophysics (Western University) Postdoctoral Fellow – Brain Endothelium (University of Miami, Miller School of Medicine) Postdoctoral Fellow – Endocrinology (The University of Tennessee Health Science Center) Postdoctoral Position – Angiogenesis and Tumor Biology (University of Illinois) Postdoctoral Fellow – Tumor and Immune Angiogenesis (Stanford University) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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Home Endothelial Cell News Volume 2.26 | Jul 31 2017