Endothelial Cell News 2.30 September 11, 2017 | |
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TOP STORYYAP/TAZ Orchestrate VEGF Signaling during Developmental Angiogenesis Researchers showed that the Hippo pathway effectors, YAP and TAZ, work as crucial signal transducers to mediate vascular endothelial growth factor (VEGF)-VEGFR2 signaling during angiogenesis. They demonstrated that YAP/TAZ are essential for vascular development as endothelium-specific deletion of YAP/TAZ leads to impaired vascularization and embryonic lethality. [Dev Cell] Abstract | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Investigators previously showed that the extracellular transglutaminase 2 (TG2) is involved in maintaining tubule formation in endothelial cell (ECs) by a mechanism involving matrix-bound vascular endothelial growth factor signaling. By using the ECs and fibroblast co-culture and ECs 3D culture models, they demonstrated a further role for TG2 in both endothelial tubule formation and in tubule loss, which involved its role in the regulation of transforming growth factor β1 and Smad signaling. [Cell Death Dis] Full Article Researchers tested the hypothesis that preconditioning with sodium hydrosulfide could enhance the capacity of migration, adhesion and proliferation of endothelial progenitor cells (EPCs) in vitro, and also could improve the efficacy of EPCs transplantation for re-endothelialization in nude mice with carotid artery injury. [Cell Physiol Biochem] Full Article Endothelial Cell Culture under Perfusion on a Polyester-Toner Microfluidic Device The authors present an inexpensive and easy way to produce a microfluidic device that mimics a blood vessel, serving as a start point for cell culture under perfusion, cardiovascular research, and toxicological studies. Endpoint assays were used and revealed that the components making up the microchip, which is made of polyester and toner, did not induce cell death or nitric oxide production. [Sci Rep] Full Article MicroRNA Profiling Reveals Distinct Profiles for Tissue-Derived and Cultured Endothelial Cells Scientists investigated the differences in miRNA profiles of tissue-derived cells and cultured endothelial cells. miRNA expression was profiled from freshly isolated tissue-derived human vascular endothelial cells and endothelial cells cultured until cellular senescence using miRNA sequencing. [Sci Rep] Full Article The authors confirmed that circulating endothelial cells changes are a suitable biomarker to monitor endothelial damage in patients undergoing allo-transplantation and hold the potential to become a useful tool to support GvHD diagnosis. [Bone Marrow Transplant] Full Article Combining 2D Angiogenesis and 3D Osteosarcoma Microtissues to Improve Vascularization To better mimic tumor angiogenesis encountered in vivo, researchers used 3D culture of osteosarcoma cells that they deposited on 2D endothelial cells grown in monolayer. They reported that endothelial cells combined with tumor cells were able to form a well-organized network, and that tubule-like structures corresponding to new vessels infiltrate tumor spheroids. [Exp Cell Res] Abstract | Graphical Abstract VEGFR2 Regulates Endothelial Differentiation of Colon Cancer Cells After culturing in endothelial-inducing conditioned medium, poorly differentiated HCT116 cells expressed endothelial markers and formed tube-like structure in vitro. HCT116 cells secreted more endogenous VE growth factor (VEGF) and expressed higher VEGF receptor 2 (VEGFR2) under hypoxia. [BMC Cancer] Full Article Scientists investigated the potential role of Danshensu in therapeutic angiogenesis in ischemic myocardium and endothelial progenitor cells function. [Eur J Pharmacol] Abstract | Graphical Abstract | |
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REVIEWSThe Roles of Vasohibin and Its Family Members: Beyond Angiogenesis Modulators The authors discuss the upstream regulatory mechanisms of vasohibin expressions, and their role in regard to the downstream target proteins of vasohibin, especially in carcinoma. Vasohibin is considered to be an original angiogenesis inhibitor, and has a much broader significance in pathological processes. It can be taken as an independent prognostic factor, as well as a potential strategy for cancer therapy programs. [Cancer Biol Ther] Abstract Visit our reviews page to see a complete list of reviews in the endothelial cell research field. | |
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SCIENCE NEWSIpsen and Exelixis, Inc. announced updated results from the CABOSUN randomized Phase II trial of cabozantinib in patients with previously untreated advanced renal cell carcinoma with intermediate- or poor-risk disease per the International Metastatic Renal Cell Carcinoma Database Consortium. [Press release from discussing research presented at the European Society for Medical Oncology (ESMO) 2017 congress, Madrid] Press Release Novartis Presents New Data Confirming Lucentis® Efficacy and Durability vs Aflibercept Novartis reported new data confirming Lucentis® efficacy and durability in patients with neovascular age-related macular degeneration (nAMD). One-year interim results from the Phase IV head-to-head RIVAL study compared ranibizumab versus aflibercept using a treat-and-extend treatment regimen in patients with nAMD. [Press release from Novartis AG discussing research presented at the 17th EURETINA Congress, Barcelona] Press Release | |
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INDUSTRY NEWSLasker Prizes Recognize Work on Cell Growth, Cancer Prevention, and Reproductive Care The Albert and Mary Lasker Foundation announced its three annual prizes, each of which comes with a $250,000 award. Regarded as the United States’s most prestigious biomedical research awards, the Laskers often precede a Nobel Prize in Physiology or Medicine: Eighty-seven Lasker laureates have gone on to win a Nobel. [ScienceInsider] Press Release Humacyte Completes Patient Enrollment for Phase III Clinical Trial of Human Acellular Vessel Humacyte announced that it has completed enrollment of 350 evaluable subjects for its Phase III HUMANITY® study of HUMACYL®, Humacyte’s investigational human acellular vessel. Conducted across 40 sites in the U.S., Europe and Israel, this pivotal Phase III clinical trial evaluates the efficacy and safety of the bioengineered blood vessel as a conduit for hemodialysis in patients with end-stage renal disease requiring renal replacement therapy and who are not candidates for fistula. [Humacyte, Inc. (Business Wire, Inc.)] Press Release | |
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POLICY NEWSPall Hangs over U.S.-Iran Science Ties Rising tensions between the U.S. and Iranian governments have frozen most scientific contacts between the two nations, experts reported at a forum. [ScienceInsider] Editorial South Korean Researchers Lobby Government to Lift Human-Embryo Restrictions More than a decade after a fraud scandal in stem-cell science rocked South Korea, scientists in the field are ramping up pressure on the government to relax the country’s strict regulations on human-embryo research — which many researchers label a ban. The nation’s bioethics committee held a public forum with the Ministry of Health and Welfare in Seoul, inviting 11 researchers and scholars to discuss possible changes to the country’s bioethics policies on research. [Nature News] Editorial The Minister of Science, Kirsty Duncan, announced $515 million in support for fundamental research through the Natural Sciences and Engineering Research Council of Canada’s (NSERC) 2017 competition for the Discovery Grants program, scholarships and fellowships. This is NSERC’s largest annual investment, and it assists researchers by offering financial support though scholarships, fellowships, research supplements, and equipment grants. [Natural Sciences and Engineering Research Council of Canada] Editorial Senate Panel Seeks Middle Ground on Human Fetal Tissue Research and Abortion A Senate spending panel countered a move by its House of Representatives counterpart to quash federal funding for research that uses human fetal tissue from elective abortions. The move sets up a conflict that will need to be resolved when lawmakers meet later this year to hash out differences between the House and Senate bills, which will provide funding for the National Institutes of Health in the 2018 fiscal year. [ScienceInsider] Editorial
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EVENTSNEW Keystone Symposia: Tumor Metabolism Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Fellow – Inflammation and Endothelial Cell Biology (University of Gothenburg) Postdoctoral Fellow – Vascular Cell Signaling (Louisiana State University Health Sciences Center) Postdoctoral Fellowship – Smooth Muscle and Endothelial Function (University of Iowa) Postdoctoral Position – Vascular Biology Relating to Cardiovascular Diseases (University of Hawaii) Postdoctoral Position – Biology of Blood Platelets (INSERM) Tenure-Track Faculty Scientist – Metabolic Disease (Temple University) Assistant Professor – Stem Cell and Regenerative Medicine (Harvard University) Postdoctoral Research Scientist – Tissue Repair (The University of Alabama) Postdoctoral Research Scientist – Drug Discovery and Cell Therapy (Inserm) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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Home Endothelial Cell News Volume 2.30 | Sep 11 2017