Endothelial Cell News 2.37 November 6, 2017 | |
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TOP STORYEndothelial Cell-Derived GABA Signaling Modulates Neuronal Migration and Postnatal Behavior With the use of two new endothelial cell specific conditional mouse models of the GABA pathway, scientists showed that partial or complete loss of GABA release from endothelial cells during embryogenesis results in vascular defects and impairs long-distance migration and positioning of cortical interneurons. [Cell Res] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)The authors generated bifunctional 40 nm-sized silica nanoparticles (NPs) coated with controlled amounts of cRGD and ATWLPPR peptides and studied their affinity, selectivity and biological activity in HUVECs. Sub-nanomolar concentrations of NPs grafted either with ATWLPPR alone or in combination with cRGD exhibited potent and specific antagonist activity against VEGFR2/AKT signaling. [Biomaterials] Abstract | Graphical Abstract Scientists characterized vascular injury and functional recovery to understand the role of circulating endothelial progenitor cells in vascular repair. Migration of endothelial cells derived from endothelial outgrowth colonies correlated with arterial function before catheterization, but was not related to recovery of function following injury. [J Am Heart Assoc] Full Article Researchers determined the key role of 12-lipoxygenase/12-hydroxyeicosatetraenoic acid in angiogenesis and survival of pulmonary artery endothelial cells, and ascertain the signaling pathways participated in the pathological process. They identified that hypoxia increases the formation of endogenous 12-hydroxyeicosatetraenoic acid through stimulation of 12-lipoxygenase. [Am J Physiol Lung Cell Mol Physiol] Abstract CCR6 Promotes Tumor Angiogenesis via the AKT/NF-κB/VEGF Pathway in Colorectal Cancer Investigators found that CCR6 was significantly overexpressed in colorectal cancer (CRC) tissues and predicted a poor prognosis in CRC patients. They observed that silencing CCR6 could decrease angiogenesis by inhibiting the proliferation and migration of HUVECs, whereas overexpression of CCR6 can promote angiogenesis. [Biochim Biophys Acta] Abstract | Graphical Abstract Researchers developed and investigated the therapeutic potential of an innovative liposomally-formulated short-interfering RNA (siRNA) technology based on clinical stage components, capable to attenuate production of the endothelial kinase insert domain receptor (KDR), which controls portosystemic collateralization and contributes to disease progression and aggravation. [Sci Rep] Full Article The authors investigated the mechanisms of cadmium (Cd)-induced endothelial toxicity in a human model system of H9 human pluripotent stem cell-derived endothelial cells (H9-ECs). They showed that H9-ECs were susceptible to CdCl2 induction, leading to detrimental changes of cell structure and significantly elevated level of apoptosis. [Sci Rep] Full Article Investigators examined whether anoctamin-1 (Ano1) was expressed in pulmonary endothelial cells (ECs) and if altering Ano1 activity would affect EC survival. Ano1 was expressed in rat lung microvascular ECs (RLMVECs) and was enriched in the mitochondria. Activation of Ano1 with Eact reduced RLMVEC counts through increased apoptosis. [Am J Respir Cell Mol Biol] Abstract Researchers studied the inhibition of H2-P vascular endothelial cells. The data showed that H2-P could increase endothelial cells apoptosis rate, while inhibiting endothelial cell proliferation and migration. [J Cell Biochem] Abstract | |
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REVIEWSThe Vascular Endothelium: A Regulator of Arterial Tone and Interface for the Immune System The authors discuss several key aspects of endothelial function, how this may be compromised and subsequent consequences. Specifically, they examine the dynamic regulation of arterial contractility and distribution of blood flow through the generation of chemical and electrical signaling events that impinge upon vascular smooth muscle. [Crit Rev Clin Lab Sci] Abstract Visit our reviews page to see a complete list of reviews in the endothelial cell research field. | |
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SCIENCE NEWSAVEO Oncology and EUSA Pharma announced the presentation of promising results from the ongoing Phase I portion of the TiNivo study, a Phase I/II multicenter trial of tivozanib in combination with Bristol-Myers Squibb’s nivolumab, an immune checkpoint, or PD-1, inhibitor, for the treatment of advanced renal cell carcinoma. [Press release from AVEO Oncology discussing research presented at the 16th International Kidney Cancer Symposium (IKCS), Miami] Press Release OrbusNeich reported results from the REDUCE trial in the Late-Breaking Clinical Trial session, providing fresh insights into the optimal treatment of patients with acute coronary syndrome using the COMBO Dual Therapy Stent. [Press release from OrbusNeich Medical, Inc. (PR Newswire Association LLC.) discussing research presented at the 29th Annual Transcatheter Cardiovascular Therapeutics (TCT) Scientific Symposium, Denver] Press Release | |
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INDUSTRY NEWSChi Med Initiates FRUTIGA, a Phase III Trial of Fruquintinib in Second-Line Gastric Cancer Hutchison China MediTech Limited (Chi Med) initiated FRUTIGA, a pivotal Phase III clinical trial of fruquintinib in combination with paclitaxel for the treatment in advanced gastric or gastroesophageal junction adenocarcinoma patients in China. [Hutchison China MediTech Limited] Press Release Bexion Pharmaceuticals, Inc. announced the start of a Phase Ib study of BXQ-350, an open-label study in adult patients with advanced solid tumors. In the Phase Ia trial, BXQ-350 was well tolerated at all five dose levels with no dose limiting toxicities observed and with no serious adverse events attributed to the therapy. [Bexion Pharmaceuticals, Inc.] Press Release | |
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POLICY NEWSControversial Chairman of US House Science Committee to Retire Representative Lamar Smith, the controversial chair of the US House of Representatives’ science committee, will retire when his term expires late next year. [Nature News] Editorial Leading Western Publisher Bows to Chinese Censorship Springer Nature, whose publications include Nature and Scientific American, acknowledged that at the government’s request, it had removed articles from its mainland site that touch on topics the ruling Communist Party considers sensitive, including Taiwan, Tibet, human rights and elite politics. [The New York Times] Editorial
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EVENTSNEW 14th Annual Stem Cell Symposium: Technology Innovation for Stem Cell Research and Therapy Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Principal Scientist – Cardiovascular Research (Novo Nordisk) Postdoctoral Positions – Molecular Neurobiology (San Raffaele Institute) Postdoctoral Research Fellow – Lung and Vascular Biology (University of Illinois at Chicago) Postdoctoral Research Assistant – Bone and Vascular Biology (University of Oxford) PhD Studentship – Cardiovascular Research (Max Planck Institute for Heart and Lung Research) Postdoctoral Position – Basic Neuroscience (McLean Hospital/Harvard Medical School) Scientist – Angiogenesis (University of East Anglia) Postdoctoral Position – Biology of Blood Platelets (INSERM) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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