Endothelial Cell News 2.40 December 4, 2017 | |
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TOP STORYCombining Machine and Nanoparticles for Better Transplant Outcomes By combining the use of drug-carrying nanoparticles with an organ-preserving machine, researchers have developed a procedure that could help improve long-term outcomes for transplant recipients. [Press release from Yale University discussing online prepublication in Science Translational Medicine] Press Release | Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)The authors found that deletion of hypoxia-inducible factor (HIF)-1α in natural killer cells inhibited tumor growth despite impaired tumor cell killing. Tumors developing in these conditions were characterized by a high-density network of immature vessels, severe hemorrhage, increased hypoxia, and facilitated metastasis due to non-productive angiogenesis. [Nat Commun] Full Article Investigators demonstrated in human and mouse that endothelial cells and myogenic progenitor cells interacted together to couple myogenesis and angiogenesis in vitro and in vivo during skeletal muscle regeneration. Apelin, oncostatin M, and periostin were shown to control myogenesis/angiogenesis coupling in vitro and to be required for myogenesis and vessel formation during muscle regeneration in vivo. [Stem Cell Reports] Full Article | Graphical Abstract Researchers studied the effects of particulate matter (PM2.5) on endothelial progenitor cell (EPC)-mediated recovery of vascular perfusion after hindlimb ischemia and examined the mechanisms whereby PM2.5 exposure affects EPC abundance and function. [Arterioscler Thromb Vasc Biol] Abstract miR-126-5p Promotes Retinal Endothelial Cell Survival through SetD5 Regulation in Neurons Investigators showed that miR-126-5p is expressed in endothelial but also by retinal ganglion cells (RGC) of the postnatal retina and participates in protecting endothelial cells from apoptosis during the establishment of the retinal vasculature. miR-126-5p negatively controlled class-3 semaphorin protein in RGC through the repression of SetD5, an uncharacterized member of the methyltransferase family of proteins. [Development] Abstract Scientists examined whether and how 2-methoxyestradiol could improve vascular malformations. Intracranial venous hypertension model produced in adult male Sprague-Dawley rats and culture of HUVECs at the anoxia condition were used to induce in vivo and in vitro angiogenesis, respectively. [J Cell Mol Med] Full Article The authors report a new hydrogel-based composite that offers impressive printability, shape integrity, and biocompatibility for 3D bioprinting of a perfusable complex vasculature-like structure. The hydrogel composite can be used on a non-liquid platform and is printable at human body temperature. [Sci Rep] Full Article Multi-Physics Interactions Drive VEGFR2 Relocation on Endothelial Cells Ligand stimulation induced the polarization of endothelial cells and the relocation of VEGF receptor-2 (VEGFR2), either in cell protrusions or in the basal aspect in cells plated on ligand-enriched extracellular matrix. Scientists developed a mathematical model in order to simulate the relocation of VEGFR2 on the cell membrane during the mechanical adhesion of cells onto a ligand-enriched substrate. [Sci Rep] Full Article In Vivo Tropism of Salmonella Typhi Toxin to Cells Expressing a Multiantennal Glycan Receptor Researchers showed that typhoid toxin displays in vivo tropism to cells expressing multiantennal glycoprotein receptors, particularly on endothelial cells of arterioles in the brain and immune cells, which is in line with typhoid symptoms. Neu5Ac displayed by multiantennal N-glycans, rather than a single Neu5Ac, appeared to serve as the high-affinity receptor, as typhoid toxin possesses five identical binding pockets per toxin. [Nat Microbiol] Abstract | |
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REVIEWSThe involvement of the endothelial cells in bicuspid aortic valve (BAV) thoracic aortic aneurysm (TAA) pathogenesis is discussed. Endothelial cell functioning in vessel homeostasis, flow response and signaling is highlighted to give an overview of the importance and the under investigated potential of endothelial cells in BAV-associated TAA. [Front Physiol] Full Article Visit our reviews page to see a complete list of reviews in the endothelial cell research field. | |
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INDUSTRY NEWSIronwood Pharmaceuticals, Inc. announced encouraging top-line results from two Phase IIa studies of IW-1973, Ironwood’s lead investigational soluble guanylate cyclase stimulator, in patients with type 2 diabetes and hypertension. [Ironwood Pharmaceuticals, Inc.] Press Release TRACON Doses First Patient in Phase Ib Study of TRC105 with Opdivo® in Patients with Lung Cancer TRACON Pharmaceuticals announced that the first patient has been dosed in its Phase Ib clinical trial of TRC105 in combination with Opdivo® in patients with non-small cell lung cancer. [TRACON Pharmaceuticals, Inc.] Press Release | |
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POLICY NEWSBiohackers Disregard FDA Warning on DIY Gene Therapy Despite a warning from the federal government about do-it-yourself (DIY) gene therapy, two companies say they’ll continue offering DNA-altering materials to the public. The companies, The Odin and Ascendance Biomedical, both recently posted videos online of people self-administering DNA molecules their labs had produced. [MIT Technology Review] Editorial China to Roll Back Regulations for Traditional Medicine despite Safety Concerns Support for traditional medicine in China goes right to the top. President Xi Jinping has called this type of medicine a “gem” of the country’s scientific heritage and promised to give alternative therapies and Western drugs equal government support. The country is taking dramatic steps to promote these cures even as researchers raise concerns about such treatments. [Nature News] Editorial
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EVENTSNEW 11th Dutch Stem Cell Meeting Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Position – Cardiac Metabolism (University of British Columbia) Research Technologist – Mesenchymal and Endothelial Cells (STEMCELL Technologies Inc.) Postdoctoral Fellow – Physiology (The University of Tennessee Health Science Center) PhD & Postdoctoral Positions – Neurovascular Biology (Université Libre de Bruxelles) Principal Scientist – Cardiovascular Research (Novo Nordisk) Postdoctoral Positions – Molecular Neurobiology (San Raffaele Institute) Postdoctoral Research Fellow – Lung and Vascular Biology (University of Illinois at Chicago) PhD Studentship – Cardiovascular Research (Max Planck Institute for Heart and Lung Research) Postdoctoral Position – Biology of Blood Platelets (INSERM) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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