Endothelial Cell News 2.41 December 11, 2017 | |
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TOP STORYMyosin IIa Is Critical for cAMP-Mediated Endothelial Secretion of von Willebrand Factor The authors report that myosin IIa is expressed both in primary human endothelial cells and intact mouse vessels, essential for cAMP-mediated endothelial von Willebrand factor (VWF) secretion. Endothelium-specific myosin IIa knockout mice exhibited impaired epinephrine-stimulated VWF release, prolonged bleeding time and thrombosis. [Blood] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)By comparing changes in chromatin interactions between human umbilical vein endothelial cells (ECs), embryonic stem cells and mesendoderm cells, scientists identified regions exhibiting EC-specific compartmentalization and changes in the degree of connectivity within topologically associated domains. [Nucleic Acids Res] Full Article Wnt Inhibition Promotes Vascular Specification of Embryonic Cardiac Progenitors Using transgenic mice and human pluripotent stem cells (hPSCs), researchers tracked endothelial cells (ECs) that originated from cardiac progenitor cells (CPCs) expressing Nkx2.5. Analysis of EC-fated CPCs at discrete phenotypic milestones during hPSC differentiation identified reduced Wnt activity as a hallmark of EC specification, and enforced activation or inhibition of Wnt reduced or increased, respectively, the degree of vascular commitment within the CPC population during both hPSC differentiation and mouse embryogenesis. [Development] Full Article Heme Accumulation in Endothelial Cells Impairs Angiogenesis by Triggering Paraptosis Investigators showed that alteration of heme homeostasis in endothelial cells due to the loss of the heme exporter FLVCR1a, resulted in impaired angiogenesis. They demonstrated that impaired heme export leads to endothelial cell death by paraptosis and provided evidence that endoplasmic reticulum stress precedes heme-induced paraptosis. [Cell Death Differ] Full Article Researchers evaluated the participation of NCX reverse mode (NCXrm)-mediated Ca2+ uptake in the endothelium-dependent vasodilation of rat isolated mesenteric arterial beds. [FASEB J] Abstract The possibility of using polyurethane (PU) as a coating platform for functionalization with peptide to enhance endothelialization on implants was explored. PUs were synthesized through metal-free organocatalytic polymerization followed by chemical conjugation with an endothelial cell-specific REDV peptide through thiol–ene reaction. [Adv Healthc Mater] Abstract To determine Rap1’s role in endothelial barrier dynamics, investigators examined vascular permeability in endothelial cell (EC)-specific Rap1A- and Rap1B-knockout mice, cell-cell junction remodeling and EC monolayer resistivity in Rap1-deficient ECs under basal, inflammatory or elevated VEGF conditions. [J Cell Sci] Abstract Scientists examined the role of endomucin-1 (EMCN) in angiogenesis by modulating EMCN levels both in vivo and in vitro. Reduction of EMCN in vivo led to the impairment of angiogenesis during normal retinal development in vivo. [Sci Rep] Full Article The authors revealed an unanticipated role of caveolin-1 (Cav-1) regulating lipolysis in non-adipose tissue indicating that Cav-1 is required for lipid droplet metabolism in endothelial cells and regulates cAMP dependent lipolysis, in part, via the autocrine production of prostacyclin. [J Biol Chem] Abstract Researchers investigated the effect of miR-137 on endothelial progenitor cells and angiogenesis in cerebral ischemic stroke by targeting NR4A2 via the Notch pathway. [J Cell Physiol] Abstract Scientists investigated whether angiogenesis and VEGF-expressing cells in the fascia were histologically demonstrated during the early phase of dermatomyositis, and whether inflammation was involved in angiogenesis and an increased number of VEGF-expressing cells. [Arthritis Res Ther] Full Article | |
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REVIEWSThe authors review lessons learned from the use of endothelial progenitor cells in experimental animal models with emphasis on the in vitro manipulation and delivery strategies to enhance their retention, survival and functioning post-engraftment in the heart. [Regen Med] Abstract Visit our reviews page to see a complete list of reviews in the endothelial cell research field. | |
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INDUSTRY NEWSOrtho Clinical Diagnostics announced a long-term, global strategic agreement regarding the endothelial function marker, biologically active Adrenomedullin, which measures patients’ rate of recovery from acute heart failure, providing critical information to physicians making treatment decisions. [Ortho Clinical Diagnostics (PR Newswire Association LLC.)] Press Release Regeneron Pharmaceuticals, Inc. announced that the FDA has accepted for review the company’s supplemental Biologics License Application (sBLA) for a 12-week dosing interval of EYLEA® injection in patients with wet age-related macular degeneration (wet AMD) based on physician’s assessment. [Regeneron Pharmaceuticals, Inc.] Press Release | |
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POLICY NEWSBrexit ‘Breakthrough’ Raises Hope — and Questions British science is expected to benefit from a deal that would allow EU nationals to remain in the country once it leaves the union. [Nature News] Editorial Nine Researchers Sue University of Rochester over Sexual-Harassment Allegations Nine researchers filed a federal lawsuit against the University of Rochester in New York, its president Joel Seligman and its provost Robert Clark over their handling of alleged sexual harassment by a professor there. [Nature News] Editorial U.S. Science Groups Make Last-Minute Push to Influence Final Tax Deal It wasn’t your typical graduate school experience. Eight graduate students, including doctoral students in anthropology and astrophysics at major U.S. universities, ended up in handcuffs after they refused to end a noisy protest outside the Washington, D.C., office of Speaker of the House of Representatives Paul Ryan. [ScienceInsider] Editorial
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EVENTSNEW Arteriosclerosis, Thrombosis and Vascular Biology (ATVB)/Peripheral Vascular Disease (PVD) 2018 Scientific Sessions Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW PhD Scholarships – Human Endothelial Cells in Chronic Disease (University of Hull) Research Technologist – Mesenchymal and Endothelial Cells (STEMCELL Technologies Inc.) Postdoctoral Position – Cardiac Metabolism (University of British Columbia) Postdoctoral Fellow – Physiology (The University of Tennessee Health Science Center) PhD & Postdoctoral Positions – Neurovascular Biology (Université Libre de Bruxelles) Principal Scientist – Cardiovascular Research (Novo Nordisk) Postdoctoral Positions – Molecular Neurobiology (San Raffaele Institute) Postdoctoral Research Fellow – Lung and Vascular Biology (University of Illinois at Chicago) PhD Studentship – Cardiovascular Research (Max Planck Institute for Heart and Lung Research) Postdoctoral Position – Biology of Blood Platelets (INSERM) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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