Endothelial Cell News 3.00 January 8, 2018 | |
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TOP STORYUsing genetic fate mapping, investigators showed that Smoothened mutant expression in Cre-expressing endothelial progenitors results in myogenic transdifferentiation and rhabdomyosarcoma. [Cancer Cell] Abstract | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Yes-associated protein binding sustained signal transducer and activator of transcription 3 in the nucleus to enhance the latter’s transcriptional activity and promote angiogenesis via regulation of angiopoietin-2. [Circ Res] Abstract Investigators evaluated whether the bone marrow endothelial progenitor cells in corticosteroid-resistant immune thrombocytopenia (ITP) differed from those in corticosteroid-sensitive ITP. [Blood] Abstract The authors showed that VEGF-induced polarized cell elongation increases cell perimeter and decreases the relative VE-cadherin concentration at junctions, triggering polarized formation of actin-driven junction-associated intermittent lamellipodia under control of the WASP/WAVE/ARP2/3 complex. [Nat Commun] Full Article Shear-Induced Notch-Cx37-p27 Axis Arrests Endothelial Cell Cycle to Enable Arterial Specification Researchers demonstrated that fluid shear stress, at arterial flow magnitudes, maximally activates NOTCH signaling, which upregulates GJA4 and downstream cell cycle inhibitor CDKN1B. [Nat Commun] Full Article Ablation of Endothelial VEGFR1 Improves Metabolic Dysfunction by Inducing Adipose Tissue Browning Investigators report the physiological functions of VEGFR1 in the modulation of adipose angiogenesis, obesity, and global metabolism. Pharmacological inhibition and genetic deletion of endothelial VEGFR1 augmented adipose angiogenesis and browning of subcutaneous white adipose tissue, leading to elevated thermogenesis. [J Exp Med] Abstract The authors established a 3D angiogenesis model by co-culturing adipose-derived stromal cells (ASCs) and endothelial cells (ECs) in collagen gel and found that ASC-EC-instructed angiogenesis was regulated by the canonical Wnt pathway. [Bone Res] Full Article Scientists found that anti-Interleukin-3R-EV treatment prevented neovessel formation and, more importantly, also induced the regression of in vivo tumor-derived endothelial cell-derived neovessels. [Oncogene] Full Article The authors identified that EphB3 receptors function as a pro-apoptotic dependence receptor in endothelial cells that contributes to increased blood–brain barrier damage after CCI injury. [Cell Death Dis] Full Article Researchers recombinantly produced full-length human decorin under good laboratory practice conditions, and after detailed immunological characterization, they investigated its potential to attract murine and human endothelial progenitor cells. [Sci Rep] Full Article Effects of Resistance Exercise on Endothelial Progenitor Cell Mobilization in Women Scientists determined the effect of a single bout of resistance exercise at different intensities on the mobilization of circulating endothelial progenitor cells over 24 hours in women. [Sci Rep] Full Article | |
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REVIEWSTargeting Therapeutics to Endothelium: Are We There Yet? Vascular endothelial cells represent an important therapeutic target in many pathologies, including inflammation, oxidative stress, and thrombosis; however, delivery of drugs to this site is often limited by the lack of specific affinity of therapeutics for these cells. [Drug Deliv Transl Res] Abstract Visit our reviews page to see a complete list of reviews in the endothelial cell research field. | |
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INDUSTRY NEWSTRACON Pharmaceuticals and Ambrx, Inc. announced that they have entered into a licensing agreement for the development and commercialization of TRACON’s proprietary endoglin antibody, TRC105, in China. TRC105 is a novel, clinical stage antibody to endoglin, a protein overexpressed on proliferating endothelial cells that is essential for angiogenesis, the process of new blood vessel formation. [TRACON Pharmaceuticals] Press Release Momenta Pharmaceuticals, Inc. and Mylan N.V. announced the development strategy for M710, a proposed biosimilar to EYLEA® injection. EYLEA is the market-leading VEGF inhibitor indicated for the treatment of neovascular age-related macular degeneration, macular edema following retinal vein occlusion, diabetic macular edema and diabetic retinopathy in patients with diabetic macular edema. [Momenta Pharmaceuticals, Inc.] Press Release | |
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POLICY NEWSGermany vs Elsevier: Universities Win Temporary Journal Access after Refusing to Pay Fees The Dutch publishing giant Elsevier has granted uninterrupted access to its paywalled journals for researchers at around 200 German universities and research institutes that had refused to renew their individual subscriptions at the end of 2017. [Nature News] Editorial New NCI Director Expects Big Data to Revolutionize Cancer Research, Care Cancer researchers were nervous about who President Donald Trump would choose to replace Harold Varmus as director of the National Cancer Institute (NCI). But their fears of an unconventional candidate proved unfounded when he tapped Norman “Ned” Sharpless. Sharpless, 51, who was then director of the Lineberger Comprehensive Cancer Center at the University of North Carolina in Chapel Hill. [ScienceInsider] Editorial Nobel Laureate Will Step Down from Leading Embattled Salk Institute Elizabeth Blackburn, the Nobel Prize–winning molecular biologist who took over just two years ago as president of the Salk Institute for Biological Studies in San Diego, California, announced her intent to retire this summer. The unexpected news comes as Salk faces gender discrimination lawsuits from three veteran female scientists and Blackburn herself has been challenged for not moving quickly enough to change what one plaintiff’s suit called an “old boys club” at the renowned research institute. [ScienceInsider] Editorial
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EVENTSNEW Gordon Research Conferences: Fibroblast Growth Factors in Development and Disease Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW PhD Student – Hepatic Endothelial Cells (German Cancer Research Center) NEW PhD Student – Angiogenesis and Vessel Malformation and Function (Karolinska Institutet) NEW PhD Scholarship – Cardiovascular Science (Università degli Studi di Verona) NEW PhD Positions – Angiogenesis and Vascular Metabolism (VIB) PhD Scholarships – Human Endothelial Cells in Chronic Disease (University of Hull) Postdoctoral Position – Cardiac Metabolism (University of British Columbia) Postdoctoral Fellow – Physiology (The University of Tennessee Health Science Center) Postdoctoral Position – Biology of Blood Platelets (INSERM) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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