Endothelial Cell News 3.02 January 22, 2017 | |
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TOP STORYScientists studied how genetic and pharmacological manipulation of endothelial Notch signaling in adult mice affects endothelial fatty acid transport, cardiac angiogenesis, and heart function. Inhibition of Notch signaling specifically in the endothelium of adult mice by genetic ablation of Rbp-jκ caused heart hypertrophy and failure. [Circulation] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Researchers identified an enhancer-associated long non-coding RNA that enhances endothelial nitric oxide synthase (eNOS) expression (LEENE). Combining RNA-sequencing and chromatin conformation capture methods, they demonstrated that LEENE is co-regulated with eNOS and that its enhancer resides in proximity to eNOS promoter in endothelial cells. [Nat Commun] Full Article The lncRNA GATA6-AS Epigenetically Regulates Endothelial Gene Expression via Interaction with LOXL2 Investigators showed that the long non-coding antisense transcript of GATA6 (GATA6-AS) interacts with the epigenetic regulator LOXL2 to regulate endothelial gene expression via changes in histone methylation. Using RNA deep sequencing, they found that GATA6-AS is upregulated in endothelial cells during hypoxia. [Nat Commun] Full Article The authors studied binding to endothelial protein C receptor (EPCR) by Plasmodium falciparum-infected erythrocytes (IEs) expressing DC8 and DC13 P. falciparum erythrocyte membrane protein 1 (PfEMP1) variants whose recombinant proteins have been used in key prior functional and structural studies. IE binding to EPCR immobilized on plastic and on human brain endothelial cells was examined in static and flow adhesion assays. [Proc Natl Acad Sci USA] Full Article Scientists identified a subset of endoglin-expressing endothelial cells enriched in human bone marrow during fetal ontogeny and upon regeneration after chemotherapeutic injury. Interleukin-33 (IL-33) was significantly overexpressed in these endothelial cells and promoted the expansion of distinct subsets of hematopoietic precursor cells, endothelial cells, as well as osteogenic differentiation. [Cell Rep] Full Article | Graphical Abstract The authors report that mice lacking Drosha in the vascular endothelium developed a vascular phenotype resembling hereditary hemorrhagic telangiectasia that included dilated and disorganized vasculature, arteriovenous fistulae, and hemorrhages. [Sci Signal] Abstract Akap1 Regulates Vascular Function and Endothelial Cells Behavior Although mitochondrial alterations have been associated to endothelial dysfunction, the role of mitochondrial A kinase anchoring proteins in the vasculature is currently unknown. To test this, postischemic neovascularization, vascular function, and arterial blood pressure were analyzed in Akap1 knockout mice and their wild-type littermates. [Hypertension] Abstract Researchers generated a mouse model of vascular malformations by local expression of PIK3CA-activating mutation in endothelial cells. The expression of PIK3CA-activating mutations in human endothelial cells results in both increased proliferation rates and senescence. [Cell Death Dis] Full Article Investigators proved that autophagy determines the therapeutic effect of mesenchymal stem cells (MSCs) in cutaneous wound healing through promoting endothelial cells angiogenesis and demonstrated that the paracrine of VEGF in MSCs was required in wound site. [Cell Death Dis] Full Article The proangiogenic effects of a 20-amino-acid osteopontin peptide (OPNpt20) containing arginine-glycine-aspartate (RGD) and serine-leucine-alanine-tyrosine (SLAY) motifs were examined in HUVECs and in a rat focal cerebral ischemia model. OPNpt20 exerted robust proangiogenic effects in HUVECs by promoting proliferation, migration and tube formation. [Exp Mol Med] Full Article Human retinal microvascular endothelial cells (HRECs) were employed to investigate the impact of miR-210 on the angiogenic capacity of retinal endothelial cells. It was observed that without affecting the viability of HRECs, miR-210 significantly suppressed the migration and capillary-like tube formation in HRECs. [Angiogenesis] Abstract | |
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REVIEWSEndothelial Ca2+ Signaling and the Resistance to Anticancer Treatments: Partners in Crime The author describes how remodeling of the endothelial Ca2+ toolkit contributes to establish intrinsic or acquired resistance to standard anti-cancer therapies. The endothelial Ca2+ toolkit undergoes a major alteration in tumor endothelial cells and tumor-associated endothelial colony forming cells. [Int J Mol Sci] Full Article Visit our reviews page to see a complete list of reviews in the endothelial cell research field. | |
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INDUSTRY NEWSSecant Group Develops the First Synthetic Regenerative Cardiovascular Graft Secant Group, in partnership with its sister company SanaVita Medical, announced game changing technology to advance cardiovascular regenerative medicine with the development of a synthetic, small bore, vessel that encourages endogenous regeneration and new vessel formation. [Secant Group, LLC] Press Release Amgen and Allergan plc. announced that the European Commission has granted marketing authorization for MVASI®. MVASI is a biosimilar to bevacizumab, a recombinant immunoglobulin G1 monoclonal antibody that binds to VEGF and inhibits the interaction of VEGF with its receptors, VEGF receptor-1 and VEGF receptor-2, thus inhibiting establishment of new blood vessels necessary for the maintenance and growth of solid tumors. [Amgen Inc.] Press Release | |
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POLICY NEWSU.S. Scientists Breathe a Sigh of Relief as Government Shutdown to End It’s over—at least for the moment. The U.S. Senate voted 81–18 to advance legislation funding government activities, essentially ending a partial government shutdown that had moved into its third day. The House of Representatives is expected to follow suit, sending the bill to President Donald Trump for his signature. [ScienceInsider] Editorial Online Tool Calculates Reproducibility Scores of PubMed Papers A new online tool measures the reproducibility of published scientific papers by analyzing data about articles that cite them. The software comes at a time when scientific societies and journals are alarmed by evidence that findings in many published articles are not reproducible and are struggling to find reliable methods to evaluate whether they are. [ScienceInsider] Editorial India’s Education Minister Assails Evolutionary Theory, Calls for Curricula Overhaul A new front has opened in the war on science in India. India’s minister for higher education, Satyapal Singh, took aim at the theory of evolution. Calling himself “a responsible man of science,” Singh, a chemist, suggested that Darwin’s theory is “scientifically wrong” and “needs to change” in school and university curricula. [ScienceInsider] Editorial
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EVENTSNEW Annual Meeting of the Israel Stem Cell Society 2018 Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Research Fellow – Therapeutic Angiogenesis (University of Michigan) Postdoctoral Fellow – Vascular Biology (City of Hope) Research Faculty Position – Ophthalmology and Visual Science (Yale University) PhD Scholarship – Cardiovascular Science (Università degli Studi di Verona) PhD Positions – Angiogenesis and Vascular Metabolism (VIB) PhD Scholarships – Human Endothelial Cells in Chronic Disease (University of Hull) Postdoctoral Position – Cardiac Metabolism (University of British Columbia) Postdoctoral Position – Biology of Blood Platelets (INSERM) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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