Endothelial Cell News 3.03 January 29, 2018 | |
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TOP STORYClonal Expansion of Endothelial Cells Contributes to Ischemia-Induced Neovascularization Scientists elucidated whether clonal expansion contributes to vessel growth by using Confetti mice for genetic tracing of clonally expanding endothelial cells. [Circ Res] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)In order to study the contribution of Tie1 to tumor progression and metastasis, the authors conditionally deleted Tie1 in endothelial cells at different stages of tumor growth and metastatic dissemination. [J Clin Invest] Full Article Endothelial Deletion of Ino80 Disrupts Coronary Angiogenesis and Causes Congenital Heart Disease Scientists showed that deletion of the Ino80 chromatin remodeler in vascular endothelial cells prevents ventricular compaction in the developing mouse heart. [Nat Commun] Full Article | Press Release The authors showed that activation of central nervous system (CNS) endothelial cells by interleukin (IL)-1β enables inflammatory monocytes to enter the CNS and differentiate into antigen-presenting cells. [Proc Natl Acad Sci USA] Abstract Researchers found that after infection, neutrophils were almost immediately recruited to the lymph nodes via specialized blood vessels to cut bacteria off at the pass. [Proc Natl Acad Sci USA] Abstract miR‐29 Contributes to Normal Endothelial Function and Can Restore It in Cardiometabolic Disorders Researchers investigated the role of miRNA in endothelial dysfunction in the setting of cardiometabolic disorders represented by type 2 diabetes mellitus. [EMBO Mol Med] Full Article Investigators demonstrated that miR-153 directly inhibits expression of hypoxia-inducible factor 1-alpha (HIF1α) by binding to the 3′UTR of HIF1A mRNA, as well as suppresses tube formation of primary HUVECs and breast cancer angiogenesis by decreasing the secretion of VEGFA. [Oncogene] Full Article Simultaneous overexpression of FLI1 and activation of PKC rapidly and efficiently induced differentiation of human embryonic stem cells (hESCs) into induced endothelial cells (iECs) within three days, while neither FLI1 overexpression nor PKC activation alone could derive iECs from hESCs. [Cell Death Dis] Full Article Using a combination of in vitro and in vivo techniques and employing human and mouse endothelial cells under physiologic and pathologic conditions, the authors found only modest or non-significant effects in response to antibodies to PECAM-1, whether given solo or in pairs. [Sci Rep] Full Article Scientists report the increased expression of soluble ephrin-A1 in supernatants of bladder cancer cell lines co-cultured with HUVECs compared with that in immortalized uroepithelial cells co-cultured with HUVECs. [Sci Rep] Full Article Cell-Free Hemoglobin Promotes Primary Graft Dysfunction through Oxidative Lung Endothelial Injury Investigators hypothesized that cell-free hemoglobin contributes to primary graft dysfunction by increasing lung microvascular permeability and tested this in patients, ex vivo human lungs, and cultured human lung microvascular endothelial cells. [JCI Insight] Abstract | |
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REVIEWSDefining the Role of the Tumor Vasculature in Antitumor Immunity and Immunotherapy The authors discuss emerging evidence highlighting the major role played by tumor-associated blood and lymphatic vasculature in thwarting immunosurveillance mechanisms and antitumor immunity. They also discuss novel therapeutic approaches targeting the tumor vasculature and their potential to help overcoming immunotherapy resistance. [Cell Death Dis] Full Article Visit our reviews page to see a complete list of reviews in the endothelial cell research field. | |
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INDUSTRY NEWSAnGes, Inc. announced the submission of an application for marketing approval to the Pharmaceuticals and Medical Devices Agency (PMDA) of Japan for HGF plasmid, an investigational gene therapy for the treatment of critical limb ischemia, the most severe condition of peripheral arterial disease. [AnGes, Inc.] Press Release UF Launches New Center for Regenerative Medicine The University of Florida (UF) has launched a Center for Regenerative Medicine to develop lifesaving therapies “to heal the body from within” using stem cells that repair damaged tissue and organs. [University of Florida] Press Release | |
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POLICY NEWSComputer Scientist to Lead French Research Giant; Interim Head Leaves Amid Misconduct Allegations Computer scientist Antoine Petit, 57, is the new head of Europe’s largest research organization. There was an unusual twist to Petit’s appointment, however. A week before the official procedure ended, the French government named Petit interim president of the National Center for Scientific Research, a position that had been held by cell biologist Anne Peyroche since Fuchs’s departure. [ScienceInsider] Editorial German Scientists Hope for Windfall from Incoming Government Research budget could rise to 3.5% of gross domestic product if agreement struck during coalition talks holds. [Nature News] Editorial
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EVENTSNEW Advances in Cell and Tissue Culture (ACTC) 2018 Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Position – Angiogenesis and Vessel Malformation (Karolinska Institutet) Postdoctoral Research Fellow – Therapeutic Angiogenesis (University of Michigan) Postdoctoral Fellow – Vascular Biology (City of Hope) Research Faculty Position – Ophthalmology and Visual Science (Yale University) PhD Scholarship – Cardiovascular Science (Università degli Studi di Verona) PhD Positions – Angiogenesis and Vascular Metabolism (VIB) PhD Scholarships – Human Endothelial Cells in Chronic Disease (University of Hull) Postdoctoral Position – Biology of Blood Platelets (INSERM) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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