Endothelial Cell News Volume 3.07 | Mar 5 2018

TOP STORY

Antiphospholipid Antibodies Induce Thrombosis by PP2A Activation via apoER2-Dab2-SHC1 Complex Formation in Endothelium

Investigators showed that in endothelial cells the apoER2 cytoplasmic tail serves as a scaffold for antiphospholipid antibody-induced assembly and activation of the heterotrimeric protein phosphatase PP2A. [Blood] Abstract

(Ranked by impact factor of the journal)

A Direct Comparison of In Vitro and In Vivo Nucleic Acid Delivery Mediated by Hundreds of Nanoparticles Reveals a Weak Correlation

Using high throughput lipid nanoparticle (LNP) barcoding, scientists quantified how well LNPs delivered DNA barcodes to endothelial cells and macrophages in vitro, as well as endothelial cells and macrophages isolated from the lung, heart, and bone marrow in vivo. [Nano Lett] Abstract | Press Release | Graphical Abstract

EGFL7 Reduces CNS Inflammation in Mouse

Researchers discovered that the expression of extracellular matrix epidermal growth factor-like protein 7 (EGFL7) is increased in the CNS vasculature of patients with multiple sclerosis, and in mice with experimental autoimmune encephalomyelitis. [Nat Commun] Full Article | Press Release

Primary Cilia Sensitize Endothelial Cells to BMP and Prevent Excessive Vascular Regression

The authors showed that endothelial cells in the developing mouse retina form and use luminal primary cilia to stabilize vessel connections selectively in parts of the remodeling vascular plexus experiencing low and intermediate shear stress. [J Cell Biol] Abstract | Graphical Abstract

Ectopic GRHL2 Expression Due to Non-Coding Mutations Promotes Cell State Transition and Causes Posterior Polymorphous Corneal Dystrophy 4

Researchers demonstrated that the GRHL2 regulatory variants identified in PPCD4-affected individuals induce increased transcriptional activity in vitro. Although GRHL2 was not expressed in corneal endothelial cells in control tissue, they detected GRHL2 in the corneal “endothelium” in PPCD4 tissue. [Am J Hum Genet] Full Article

The Ablation of the Matricellular Protein EMILIN2 Causes Defective Vascularization Due to Impaired EGFR-Dependent IL-8 Production Affecting Tumor Growth

Scientists showed that EMILIN2 promotes angiogenesis by directly binding epidermal growth factor receptor, which enhances interleukin-8 (IL-8) production. In turn, IL-8 stimulated the proliferation and migration of vascular endothelial cells. [Oncogene] Abstract

Wdpcp Promotes Epicardial EMT and Epicardium-Derived Cell Migration to Facilitate Coronary Artery Remodeling

In mice expressing a loss-of-function mutant form of Wdpcp, a gene involved in ciliogenesis, the enclosure of the surface of the heart by the subepicardial coronary plexus was accelerated because of enhanced chemotactic responses to Shh. [Sci Signal] Full Article

Exosomes from Endothelial Progenitor Cells Improve the Outcome of a Murine Model of Sepsis

Investigators demonstrated that exosomal miR-126-5p and 3p suppressed LPS-induced HMGB1 and VCAM1 levels, respectively, in human microvascular endothelial cells.. [Mol Ther] Abstract

Endothelial Progenitor Cells Contribute to Neovascularization of Non-Small Cell Lung Cancer via HDAC7 Mediated Cytoskeleton Regulation and Angiogenic Genes Transcription

To explore the function of HDAC7 in neovascularization induced by endothelial progenitor cells, tube formation assay, immunofluorescence, microarray, Western blot analysis and animal models were performed. [Int J Cancer] Abstract

Lymphatic Endothelial Cells Regulate B-Cell Homing to Lymph Nodes via a NIK-Dependent Mechanism

Investigators showed that nuclear factor (NF)-κB-inducing kinase (NIK), a kinase mediating activation of the noncanonical NF-κB pathway, functions in lymphatic endothelial cells to regulate B-cell homing to lymph nodes. [Cell Mol Immunol] Abstract

Platelet-Derived Microparticles Promote Endothelial Cell Proliferation in Hypertension via miR-142-3p

The authors determined how platelets induce endothelial cell (EC) dysfunction under hypertensive conditions. EC proliferation was increased in renal hypertensive rats established by abdominal aortic coarctation compared with control rats and that elevated thrombin in plasma promoted platelet activation, which may induce the release of platelet-derived microparticles [FASEB J] Abstract | Full Article

Characterization of a Drug-Targetable Allosteric Site Regulating Vascular Endothelial Growth Factor Signaling

Based on low-resolution structures, scientists identified allosteric sites in D4–5 and D7 of vascular endothelial growth factor receptor 2 (VEGFR-2) accomplishing regulatory functions. Allosteric inhibition of VEGFR-2 signaling represented an attractive option for the treatment of neovascular diseases. [Angiogenesis] Abstract

Multipotent Adult Progenitor Cells Support Lymphatic Regeneration at Multiple Anatomical Levels during Wound Healing and Lymphedema

The authors demonstrated that, although multipotent adult progenitor cells showed potential to differentiate down the lymphatic endothelial lineage, they mainly trophically supported lymphatic endothelial cell behaviour in vitro. [Sci Rep] Full Article

Vascular Tissue Engineering: Progress, Challenges, and Clinical Promise

Scientists explore recent bioengineering advances in creating functional blood macro and microvessels, particularly featuring stem cells as a seed source. They also highlight progress in integrating engineered vascular tissues with the host after implantation as well as the exciting pre-clinical and clinical applications of this technology. [Cell Stem Cell] Abstract

The Dark Side of Tumor-Associated Endothelial Cells

Researchers discuss the molecular properties of the tumor endothelial barrier and endothelial anergy and discuss the main immunosuppressive mechanisms triggered by the tumor endothelium. [Semin Immunol] Abstract

Visit our reviews page to see a complete list of reviews in the endothelial cell research field.

Symic Bio Announces Results of Locally-Administered Therapeutic SB-030 in Preclinical Model of Vascular Intervention

Symic Bio announced results from a preclinical study of locally-applied therapeutic SB-030 in the reduction of inflammatory response and clot formation. [Press release from Symic Bio (PR Newswire Association LLC) discussing research presented at the 2018 Cardiovascular Research Technologies (CRT) Conference, Washington, D.C.] Press Release

Endologix, Inc. Announces Enrollment of the First Patient in EVAS2 IDE Clinical Study of the Nellix^® EndoVascular Aneurysm Sealing System

Endologix, Inc. announced that the first patient was treated in the EVAS2 IDE Confirmatory Clinical Study of the investigational Nellix^® EndoVascular Aneurysm Sealing System. The Nellix System is an endovascular abdominal aortic aneurysm therapy designed to seal the entire aneurysm. [Endologix, Inc.] Press Release

Frederick National Laboratory for Cancer Research and Georgetown University Launch Research, Education Collaboration

A new collaboration established between Georgetown University and the Frederick National Laboratory for Cancer Research aims to expand both institutions’ research and training missions in the biomedical sciences. [Georgetown University Medical Center] Press Release

New NSF Rules on Sexual Harassment Leave Many Questions Unanswered

The National Science Foundation (NSF) in Alexandria, Virginia, hopes that its new policy on sexual harassment will spur universities to deal more aggressively with the pervasive problem. But the additional reporting requirements, which will be officially published in the Federal Register, are far from a definitive statement about how NSF plans to deal with this complex and sensitive subject. [ScienceInsider] Editorial

EU Research Chief’s Next Act: Changing the Future of Academic Publishing

Robert-Jan Smits, one of Europe’s most powerful figures in research, has been appointed as a special envoy on open science at the European Commission, to help push efforts to make all publicly funded research in Europe freely available by 2020. [Science|Business] Editorial

NEW Gordon Research Conferences: Notch Signaling in Development, Regeneration and Disease
July 22-27, 2018
Lewiston, Maine, United States

Visit our events page to see a complete list of events in the community.

NEW Director – Whitaker Cardiovascular Institute (Boston University)

NEW Postdoctoral/Research Associate – Renal and Cardiovascular Research (University of Virginia)

Research Associate – Vascular Biology (Case Western Reserve University)

Postdoctoral Fellow & Assistant Research Scientist Positions – Cardiovascular Physiology (University of Arizona College of Medicine)

Research Fellow – Endothelial Cell Programming (Birmingham University)

Postdoctoral Associate – Bioengineering (University of Pittsburgh)

Postdoctoral Research Associate – Vascular Inflammation (University of Illinois)

PhD Studentship – Tumor Biology (University College London)

Postdoctoral Fellow – Vascular Biology (Weill Cornell Medicine)

Postdoctoral Fellow – Vascular Biology (City of Hope)

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