Endothelial Cell News 3.08 March 12, 2018 | |
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TOP STORYAntisense Therapy for a Common Corneal Dystrophy Ameliorates TCF4 Repeat Expansion-Mediated Toxicity A Fuchs endothelial corneal dystrophy subject-derived corneal endothelial cell (CEC) model was developed to probe disease mechanism and investigate therapeutic approaches. The CEC model demonstrated that the repeat expansion leads to nuclear RNA foci, with the sequestration of splicing factor proteins to the foci and altered mRNA processing. [Am J Hum Genet] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)Scientists detected that miR-23a was highly enriched in nasopharyngeal carcinoma (NPC) tissues at the metastatic or premetastatic stage, and its levels in NPC were associated with microvessel density. Subsequently, they proved that alteration of miR-23a expression modulated the growth, migration, and tube formation of HUVECs in vitro and affected the blood vessel outgrowth in the zebrafish model. [Oncogene] Full Article Scientists revealed a previously unrealized endosomal protein trafficking pathway from late endosome to mitochondria that allows extracellular proteins to reach mitochondria and execute apoptosis. [Cell Death Differ] Full Article Lymphatic Endothelial Cells Regulate B-Cell Homing to Lymph Nodes via a NIK-Dependent Mechanism Researchers showed that nuclear factor (NF)-κB-inducing kinase (NIK), a kinase mediating activation of the noncanonical NF-κB pathway, functions in lymphatic endothelial cells to regulate B-cell homing to lymph nodes. [Cell Mol Immunol] Abstract Multiple growth factors, cytokines, and proteases were identified in the endothelial progenitor cell (EPC) secretome, including angiogenin. In vitro, the EPC secretome significantly enhanced endothelial and oligodendrocyte precursor cell proliferation and potentiated oligodendrocyte precursor cell maturation. [Stroke] Abstract Ultraviolet-Irradiated Endothelial Cells Secrete Stem Cell Factor and Induce Epidermal Pigmentation Investigators showed that UV-irradiated endothelial cells significantly increased the pigmentation of melanocytes through epithelial-mesenchymal crosstalk. RNA sequence analysis and enzyme-linked immunosorbent assay showed that endothelial cells secrete more stem cell factor upon UV irradiation than non-irradiated cells. [Sci Rep] Full Article Researchers examined the regenerative potential of endothelial progenitor cells (EPC) in an in vitro model of Shiga toxin 2a-induced glomerular endothelial injury present in post-enteropathic hemolytic uremic syndrome and the mechanisms of EPC-triggered endothelial regeneration. [Am J Physiol Renal Physiol] Abstract Chondroitin Sulfate Protects Vascular Endothelial Cells from Toxicities of Extracellular Histones To elucidate the therapeutic mechanisms of chondroitin sulfate (CS) in lethal thrombosis, the authors investigated the interaction between CS and extracellular histones. Mouse vascular endothelial cells were incubated with histones in the presence of heparin or CS, and the expression of caspase-3/7 was measured. [Eur J Pharmacol] Abstract Metformin Suppresses Retinal Angiogenesis and Inflammation In Vitro and In Vivo In human retinal vascular endothelial cell culture, metformin inhibited various steps of angiogenesis including endothelial cell proliferation, migration, and tube formation in a dose-dependent manner. [PLoS One] Full Article AKIP1 Promotes Angiogenesis and Tumor Growth by Upregulating CXC-Chemokines in Cervical Cancer Cells Cancer cell proliferation was inhibited and tumor growth and angiogenesis restrained in BALB/c nude mice by suppressing A-kinase-interacting protein 1 (AKIP1) expression in cervical cancer cell lines. [Mol Cell Biochem] Abstract HMEC-1 and HUVEC had similar morphologies, size and granularity. HMEC-1 expressed endothelial markers as HUVECs, as well as functional SR-B1 receptor since the cell line was able to internalize HDL particles. [Lipids Health Dis] Full Article | |
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REVIEWSTranslational Models of Tumor Angiogenesis: A Nexus of In Silico and In Vitro Models Scientists overview the necessity of incorporating vascular networks for both in vitro and in silico cancer models and discuss recent progresses and challenges of in vitro experimental microfluidic cancer vasculature-on-chip systems and their in silico counterparts. [Biotechnol Adv] Abstract Visit our reviews page to see a complete list of reviews in the endothelial cell research field. | |
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INDUSTRY NEWSConstant Pharmaceuticals, LLC Announces Japanese Patent Issuance for TXA302 in Treatment of Stroke Constant Pharmaceuticals LLC announced that the Japanese Patent Office has issued a patent covering the use of TXA302 in the treatment of stroke. [Constant Pharmaceuticals LLC (PR Newswire Association LLC)] Press Release Eisai Co., Ltd. and Merck announced that the companies have agreed upon a strategic collaboration for the worldwide co-development and co-commercialization of LENVIMA®, an orally available tyrosine kinase inhibitor discovered by Eisai. [Eisai Co., Ltd.] Press Release | |
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POLICY NEWSKey Republican Lawmaker Releases New ‘Right-to-Try’ Legislation A key Republican lawmaker released a new version of so-called “right to try” legislation, a pivotal next step in the effort to help dying patients get access to experimental therapies. [STAT News] Editorial Scientists Win and Lose in Texas Primary Contests Texas primary was the first test for scientists seeking seats in the U.S. House of Representatives, and the results were mixed. [ScienceInsider] Editorial Police Probe of Brazilian Marijuana Researcher Sparks Protests A police investigation targeting Brazil’s most prominent marijuana researcher has ignited a wave of protest among scientists. They say that the move by authorities from the state of São Paulo threatens research freedoms at a time when science in the country faces severe problems because of draconian budget cuts. [Nature News] Editorial
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EVENTSNEW NAVBO: Vasculata™ 2018 Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postgraduate Research Assistant – Cardiovascular Medicine (University of Oxford) Director – Whitaker Cardiovascular Institute (Boston University) Postdoctoral/Research Associate – Renal and Cardiovascular Research (University of Virginia) Research Associate – Vascular Biology (Case Western Reserve University) Research Fellow – Endothelial Cell Programming (Birmingham University) Postdoctoral Associate – Bioengineering (University of Pittsburgh) Postdoctoral Research Associate – Vascular Inflammation (University of Illinois) PhD Studentship – Tumor Biology (University College London) Postdoctoral Fellow – Vascular Biology (Weill Cornell Medicine) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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