Endothelial Cell News 3.11 April 2, 2018 | |
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TOP STORYProgrammed Cell Death 5 Suppresses AKT-Mediated Cytoprotection of Endothelium The authors investigated whether programmed cell death 5 (PDCD5) regulates protein kinase B (PKB/AKT)-endothelial nitric oxide synthase (eNOS)-dependent signal transduction in the endothelium and affects atherosclerosis. Knockdown of PDCD5 accelerated HDAC3–AKT interaction, AKT and eNOS phosphorylation, and nitric oxide production in HUVECs. [Proc Natl Acad Sci USA] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)With the aim of translating the use of a human stem cell-derived endothelial cell product for treatment of critical limb ischemia in man, scientists report a GMP-compatible protocol and detailed cell tracking and efficacy data in multiple pre-clinical models. [Mol Ther] Abstract Hepatocellular carcinoma (HCC) cell-secreted exosomes promoted in vitro tubulogenesis of endothelial cells, which was strengthened by overexpressing miR-210 in HCC cells but was attenuated by repressing miR-210 or DROSHA in HCC cells. This pro-tubulogenesis effect by HCC exosomes was also abrogated by antagonizing miR-210 in endothelial cells. [Mol Ther Nucleic Acids] Full Article Characterization of Isolated Liver Sinusoidal Endothelial Cells for Liver Bioengineering Investigators isolated mouse liver sinusoidal endothelial cells and determined their ability to form capillary networks in vitro and in vivo for liver tissue engineering purposes. [Angiogenesis] Abstract Researchers found that clinically-relevant canagliflozin concentrations directly inhibit endothelial pro-inflammatory chemokine/cytokine secretion by AMP-activated protein kinase-dependent and -independent mechanisms without affecting early IL-1β signaling. [Sci Rep] Full Article Scientists proposed a systematic workflow for identification of cell wall associated ligands of pneumococcus that might adhere to the human brain microvascular endothelial cells. [Sci Rep] Full Article In order to evaluate whether introducing oligohistidine (Hn) sequence into gene carriers can promote endosomal escape and gene transfection or not, researchers designed and synthesized Arg-Glu-Asp-Val (REDV) peptide functionalized typical cell-penetrating peptide (TAT)-nuclear localization signals (NLS)-Hn peptides with different Hn sequence lengths. [J Nanobiotechnology] Full Article Investigators explored the role of miR-181c-3p and miR-181c-5p in high glucose-induced dysfunction in HUVECs by regulating leukemia inhibitory factor, their potential target with binding sites in 3-UTR region, that is also closely related to glucose metabolism. [Int J Biol Macromol] Abstract Scientists generated multivalent conjugates of basic fibroblast growth factor, a key growth factor involved in angiogenesis and wound healing, to hyaluronic acid polymer chains. The multivalent basic fibroblast growth factor (bFGF) conjugates demonstrated enhanced bioactivity compared to unconjugated bFGF in assays of cell proliferation and migration, processes critical to angiogenesis and tissue regeneration. [Biomater Sci] Abstract | Graphical Abstract The authors report that hsa-miR-6086 was markedly induced by TNFα stimulation in HUVECs, whereas cadherin 5 (CDH5) expression was greatly reduced. TNFα-induced suppression of CDH5 expression was largely prevented by inhibiting hsa-miR-6086, and hsa-miR-6086 mimic greatly decrease CDH5 expression in HUVECs, suggesting that the induction of hsa-miR-6086 is responsible for CDH5 downregulation by TNFα. [Gene] Abstract | |
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REVIEWSEndothelial MicroRNAs Regulating the NF-κB Pathway and Cell Adhesion Molecules during Inflammation Scientists highlight the role of various miRNAs in controlling the expression of E-selectin, ICAM-1, and VCAM-1: a type of regulation that can be harnessed for therapeutic prevention of inflammation-associated diseases such as atherosclerosis and sepsis. [FASEB J] Abstract Visit our reviews page to see a complete list of reviews in the endothelial cell research field. | |
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INDUSTRY NEWSExelixis, Inc. announced that its partner Ipsen received validation of the application for variation to the CABOMETYX® marketing authorization from the European Medicines Agency, the European regulatory authority, for the addition of a new indication for patients with previously treated advanced hepatocellular carcinoma. [Exelixis, Inc.] Press Release Disease Models from Human Pluripotent Stem Cells Now Commercially Available Elixirgen Scientific has begun selling a variety of cell-based human disease models after signing a new agreement, which allows the company to produce and distribute cells differentiated from the California Institute for Regenerative Medicine’s human pluripotent stem cell repository. [Elixirgen Scientific] Press Release | |
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POLICY NEWSIn Emotional Speech, CDC’s New Leader Vows to Uphold Science Robert Redfield Jr., the new director of the Centers for Disease Control and Prevention (CDC), gave a deeply personal agency-wide address in which he repeatedly underscored the importance of science and data and said the CDC’s most critical public health mission is to protect Americans “from that which we don’t expect”. [The Washington Post] Editorial Cancer Researcher at the Ohio State University Resigns following Multiple Misconduct Findings A cancer researcher has resigned from The Ohio State University in Columbus after the institution determined he had committed misconduct in eight papers. His work in designing anticancer compounds had led to millions of dollars in funding and multiple patents, as well as two compounds in clinical trials. [ScienceInsider] Editorial NIH Moves to Punish Researchers Who Violate Confidentiality in Proposal Reviews Late last year, National Institutes of Health (NIH) officials disclosed that they had discovered that someone involved in the proposal review process had violated confidentiality rules designed to protect its integrity. As a result, the agency announced in December 2017 that it would re-review dozens of applications that might have been compromised. Now, NIH says it has completed re-evaluating 60 applications and has also begun taking disciplinary action against researchers who broke its rules. [ScienceInsider] Editorial
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EVENTSNEW 16th Biennial Meeting of the International Society for Applied Cardiovascular Biology (ISACB) Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Research Associate – Nanomedicine Cellular Targeting and Trafficking (University College London) NEW Professor – Cell Biology (Universität Münster) Research Associate – Endothelial Cells (Imperial College London) Director – Whitaker Cardiovascular Institute (Boston University) Postdoctoral/Research Associate – Renal and Cardiovascular Research (University of Virginia) Postdoctoral Associate – Bioengineering (University of Pittsburgh) Postdoctoral Research Associate – Vascular Inflammation (University of Illinois) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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