Endothelial Cell News 3.13 April 16, 2018 | |
| |
TOP STORYEphrinB2/EphB4 Signaling Regulates Non‐Sprouting Angiogenesis by VEGF Scientists identified ephrinB2/EphB4 signaling as a key regulator of intussusceptive angiogenesis and its outcome under therapeutically relevant conditions. EphB4 signaling fine‐tuned the degree of endothelial proliferation induced by specific VEGF doses during the initial stage of circumferential enlargement of vessels, thereby limiting their size and subsequently enabling successful splitting into normal capillary networks. [EMBO Rep] Full Article | Graphical Abstract | |
| |
PUBLICATIONS(Ranked by impact factor of the journal)Researchers carried out accurate characterization of human induced pluripotent stem cell (hiPSC)-derived endothelial cells (ECs) from multiple hiPSC lines and compared them with primary ECs in various functional assays, which included barrier function using real-time impedance spectroscopy with an integrated assay of electric wound healing, endothelia-leukocyte interaction under physiological flow to mimic inflammation and angiogenic responses in in vitro and in vivo assays. [Stem Cell Reports] Full Article Investigators showed that cobalt treatments significantly upregulated in vitro VEGF expression, but inhibited human periosteum-derived mesenchymal stem cells growth and HUVEC network formation in co-cultures. [Acta Biomater] Abstract | Graphical Abstract The authors showed that angiotensin II (AngII)—the major effector of the renin-angiotensin system and one of the most important regulators of the cardiovascular system—induces the expression of angiogenic factor with G-patch and FHA domains 1 (AGGF1) through NF-κB, and that AGGF1 plays a key role in AngII-induced angiogenesis. [FASEB J] Abstract Scientists evaluated the therapeutic effects of exosomes secreted from adipose-derived stem cells on stress-mediated senescence of endothelial progenitor cells induced by high glucose. [Exp Mol Med] Full Article Cyclin-Dependent Kinase 5 Mediates Pleiotrophin-Induced Endothelial Cell Migration In endothelial cells, pleiotrophin (PTN) activated cyclin-dependent kinase 5 (CDK5) in an receptor protein tyrosine phosphatase beta/zeta- and phosphoinositide 3-kinase-dependent manner. Pharmacological and genetic inhibition of CDK5 abolished PTN-induced endothelial cell migration, suggesting that CDK5 mediates PTN stimulatory effect. [Sci Rep] Full Article Endothelial Cell Phenotypes Are Maintained during Angiogenesis in Cultured Microvascular Networks Investigators compared endothelial cell phenotypes along capillary sprouts in cultured ex vivo rat mesentery microvascular networks to in vivo endothelial cell phenotypes. [Sci Rep] Full Article Scientists report that activator of G-protein signaling 8 regulated VEGF receptor-3, which is another subtype of the VEGF receptor family, and mediated VEGFC signaling in human dermal lymphatic endothelial cells. [Exp Cell Res] Abstract The authors revealed the functional sites of endothelial cell-specific molecule 2 (ECSM2), the crosstalk between ECSM2 and other endothelial cell specific molecules, and the expression of ECSM2 in tissues of angiogenesis diseases. [Gene] Abstract | |
| |
REVIEWSVascularized Microfluidic Organ-Chips for Drug Screening, Disease Models and Tissue Engineering Cutting-edge techniques including 3D bioprinting and in vitro angiogenesis and vasculogenesis could be applied to vascularize a range of tissues and organoids. Scientists describe the latest developments in vascularization and prevascularization of micro-tissues and provide an outlook on potential future strategies. [Curr Opin Biotechnol] Abstract | Graphical Abstract The Caveolar Membrane System in Endothelium: From Cell Signaling to Vascular Pathology The authors survey recent evidence of the involvement of the caveolar network in endothelial cell biology and endothelial cell dysfunction. [J Cell Biochem] Abstract Visit our reviews page to see a complete list of reviews in the endothelial cell research field. | |
| |
INDUSTRY NEWSPfizer Inc. announced that the independent Data Monitoring Committee for the Phase III ATLAS trial evaluating INLYTA® as adjuvant therapy for patients at high risk of recurrent renal cell carcinoma after nephrectomy recommended stopping the trial at a planned interim analysis due to futility. INLYTA is an oral therapy that is designed to inhibit tyrosine kinases, including VEGF receptors 1, 2 and 3. [Pfizer Inc.] Press Release SIO and BTG Announce Recipients of Immuno-Oncology/Interventional Oncology Grant Program The Society of Interventional Oncology (SIO) and BTG plc announced their 2018 Interventional Oncology/Immuno-Oncology research grant recipients. [The Society of Interventional Oncology (PR Newswire Association LLC.)] Press Release | |
| |
POLICY NEWSA Final Dash across the United States: Updates from the 2018 March for Science The March for Science celebrated its anniversary. And although the turnout around the world was significantly smaller than last year, supporters haven’t lost any of their energy. [ScienceInsider] Editorial Adding a Citizenship Question to the 2020 Census Would Be Disastrous for Public Health The Trump administration’s eleventh-hour decision to add a question about citizenship to the census will almost certainly have a major chilling effect among immigrants. One expert predicts that as many as 24 million people would not be counted as a result of adding this question. This would sabotage the census, seriously compromise vital public health research, and ultimately damage the public’s health. [STAT News] Editorial Panel Calls for a Postdoc Tax and Other Measures to Help Biomedical Scientists Find Jobs The U.S. Congress, federal funding agencies, universities, and other research institutions must take significant steps, such as a postdoc “tax” and a hard cap on how long postdocs can be funded by a lab head, to better usher young biomedical scientists into viable careers, a committee from the National Academies of Sciences, Engineering, and Medicine concluded in a report. [ScienceInsider] Editorial Spain’s Biggest-Ever Science Petition Decries ‘Abandonment’ of Research Leading Spanish scientific organizations delivered a petition signed by more than 277,000 people to the national parliament in Madrid, calling on the government to stop the “progressive abandonment of science in Spain” caused by budget cuts. The petition is the largest ever on a science-policy subject in Spain. [Nature News] Editorial
| |
EVENTSNEW 6th Cambridge International Stem Cell Symposium Visit our events page to see a complete list of events in the community.
| |
JOB OPPORTUNITIESNEW Postdoctoral Fellowships – Pulmonary Vascular Disease (Indiana University School of Medicine) NEW PhD Student – Hepatic Endothelial Cells (German Cancer Research Center) Research Associate – Nanomedicine Cellular Targeting and Trafficking (University College London) Professor – Cell Biology (Universität Münster) Research Associate – Endothelial Cells (Imperial College London) Director – Whitaker Cardiovascular Institute (Boston University) Postdoctoral/Research Associate – Renal and Cardiovascular Research (University of Virginia) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
| |
Have we missed an important article or publication in Endothelial Cell News? Click here to submit! Comments or suggestions? Submit your feedback here. | |
|