Endothelial Cell News Volume 3.15 | Apr 30 2018

TOP STORY

LncRNA PVT1 Promotes Angiogenesis via Activating the STAT3/VEGFA Axis in Gastric Cancer

Researchers demonstrated that lncRNA PVT1 was upregulated and significantly associated with high-microvessel density and poor prognosis in gastric cancer. Through gain- and loss-of PVT1 expression, they found that PVT1 could induce angiogenesis within tumors, in addition to promoting tumor growth in vitro and in vivo. [Oncogene] Abstract

(Ranked by impact factor of the journal)

Biocompatible, Purified VEGF-A mRNA Improves Cardiac Function after Intracardiac Injection One Week Post-Myocardial Infarction in Swine

In small- and large-animal, permanent occlusion myocardial infarction models, VEGF-A 165 mRNA improved systolic ventricular function and limited myocardial damage. [Mol Ther Methods Clin Dev] Full Article

PA28γ Acts as a Dual Regulator of IL-6 and CCL2 and Contributes to Tumor Angiogenesis in Oral Squamous Cell Carcinoma

Researchers found that PA28γ enhanced the ability of oral squamous cell carcinoma cells to promote the migration, invasion, and tube formation of HUVECs and promoted tumor-induced angiogenesis in xenograft mice models in vivo. [Cancer Lett] Abstract

Angio-3, a 10-Residue Peptide Derived from Human Plasminogen Kringle 3, Suppresses Tumor Growth in Mice via Impeding Both Angiogenesis and Vascular Permeability

Angio-3 inhibited both VEGF- and bFGF-induced angiogenesis by inhibiting endothelial cell proliferation and migration while inducing apoptosis. When administered intravenously, angio-3 inhibited subcutaneous breast cancer and melanoma growth by suppressing both tumor angiogenesis and intra-tumor vascular permeability. [Angiogenesis] Abstract

Altered AKAP12 Expression in Portal Fibroblasts and Liver Sinusoids Mediates Transition from Hepatic Fibrogenesis to Fibrosis Resolution

A-kinase anchoring protein 12 (AKAP12) expression in portal fibroblasts and liver sinusoidal endothelial cells gradually decreased as fibrosis progressed but was restored after cessation of the fibrotic challenge. [Exp Mol Med] Full Article

MALAT1: An Epigenetic Regulator of Inflammation in Diabetic Retinopathy

Scientists established a novel epigenetic paradigm for metastasis-associated lung adenocarcinoma transcript (MALAT) in diabetic retinopathy by employing siRNA-mediated MALAT1 knockdown in human retinal endothelial cells, a Malat1 knockout animal model, vitreous humor from diabetic patients, pharmacological inhibitors for histone and DNA methylation, RNA immunoprecipitation, western blotting, and a unique DNA methylation array to determine glucose-related alterations in MALAT1. [Sci Rep] Full Article

Imaging of Angiogenesis of Human Umbilical Vein Endothelial Cells by Uptake of Exosomes Secreted from Hepatocellular Carcinoma Cells

Investigators examined the effects of the exosomes secreted from HepG2 cells on the lumen formation of HUVECs by the imaging of angiogenesis. [Sci Rep] Full Article

RASAL2 Inhibits Tumor Angiogenesis via P-AKT/ETS1 Signaling in Bladder Cancer

The authors discovered that RASAL2, a RAS GTPase activating protein, could inhibit bladder cancer angiogenesis based on their shRNA/siRNA knockdown or ectopic cDNA expression experiments. [Cell Signal] Abstract | Graphical Abstract

Curcumin Reverses Diabetes‐Induced Endothelial Progenitor Cell Dysfunction by Enhancing MnSOD Expression and Activity In Vitro and In Vivo

Researchers found that in vitro treatment of bone marrow endothelial progenitor cells from diabetic mice with curcumin restored their functionality, as judged by colony formation, tubule formation and migration assays. [J Tissue Eng Regen Med] Abstract

Stromal Interaction Molecule 1 Modulates Blood Pressure via NO Production in Vascular Endothelial Cells

The authors generated STIM1 fl/fl mice and vascular endothelial cell-specific STIM1 knockout mice using the Cre-loxP system, and conducted experiments using these mice to clarify the physiological role of STIM1 in vascular endothelial function and blood pressure. [Hypertens Res] Abstract

Feeder-Free Differentiation of Cells Exhibiting Characteristics of Corneal Endothelium from Human Induced Pluripotent Stem Cells

Investigators devised a strategy for the derivation of corneal endothelial cells from adult fibroblast-derived induced pluripotent stem cells. [Biol Open] Abstract | Full Article

Lymphatic Endothelial Progenitor Cells: Origins and Roles in Lymphangiogenesis

While embryonic veins and cells of mesenchymal origin have been recognised as sources of embryonic lymphatic endothelial cells for many years, recent advances in technology have revealed the existence of additional sources of lymphatic endothelial cells important for embryonic lymphangiogenesis. Intriguingly, distinct progenitor cell sources appear to be employed in a tissue specific manner during development. [Curr Opin Immunol] Abstract

Contribution of Tumor Endothelial Cells in Cancer Progression

The authors describe recent studies on tumor endothelial cell abnormalities related to cancer progression to provide insight into new anticancer therapies. [Int J Mol Sci] Full Article

Visit our reviews page to see a complete list of reviews in the endothelial cell research field.

STEMCELL Technologies Announces $45 Million Government Funding for Advanced Manufacturing Facility

STEMCELL Technologies announced a $45 million joint funding agreement between the Governments of Canada and British Columbia to help the company build a state-of-the-art advanced manufacturing facility. [STEMCELL Technologies Inc.] Press Release

Five Johns Hopkins Scientists Among 83 Who Will Share in $15 Million Award from Chan Zuckerberg Initiative to Fund Computer-Based Research on Human Cells

Five Johns Hopkins scientists, with specialties spanning computation, genetics, statistics and engineering, are among 83 others from 53 institutions in the U.S and eight other countries, who will share in a $15 million award from the Chan Zuckerberg Initiative. [Johns Hopkins University] Press Release

A House Too Far: Two Scientists Abandon Their Bids for Congress

When Phil Janowicz and Kristopher Larsen began their campaigns for a seat in the U.S. House of Representatives, they joined what appears to be a record number of Ph.D. scientists running for national office. But after spending months on the campaign trail, the two Democrats—an organic chemistry professor from southern California and a space physics researcher from Colorado, respectively—decided to drop out before a single ballot had been cast in their states. [ScienceInsider] Editorial

U.K. Commits to EU Trial Rules Post-Brexit as CRUK Hails ‘Fantastic News’

The U.K. government said it will endeavor to keep pace with the European Union’s impending changes in clinical trial procedures, bringing some solace to those wondering how the two will stay aligned after Brexit starts in earnest next March. [Questex LLC.] Editorial

Famed Cancer Biologist Allegedly Sexually Harassed Women for Decades

Inder Verma, the prominent geneticist and cancer scientist who has made his mark on U.S. research for decades, has sexually harassed women for just as long, according to allegations from eight women. [ScienceInsider] Editorial

NEW 10^th International Symposium on Neuroprotection and Neurorepair
October 9-11, 2018
Dresden, Germany

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Fellows – Endothelial Cell Biology (KU Leuven)

NEW Assistant/Associate/Full Professor – Translational and Vascular Biology (University of Texas Health Science Center)

Postdoctoral Researcher – Vascular Control of Adipose Tissue Metabolism (German Cancer Research Center)

Postdoctoral Fellow – Kidney Disease (University of Kansas Medical Center)

Postdoctoral Position – Vascular Biology (Uppsala University)

Postdoctoral Fellowships – Pulmonary Vascular Disease (Indiana University School of Medicine)

PhD Student – Hepatic Endothelial Cells (German Cancer Research Center)

Research Associate – Pulmonary Vascular Signaling and Endothelial Cell Biology (University of Maryland School of Medicine)

Postdoctoral Fellow/Assistant Staff Scientist – Cardiovascular Biology (Oklahoma Medical Research Foundation)

Postdoctoral/Research Associate – Renal and Cardiovascular Research (University of Virginia)

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