Endothelial Cell News Volume 3.19 | Jun 4 2018

TOP STORY

YAP Controls Endothelial Activation and Vascular Inflammation through TRAF6

Deletion of yes-associated protein (YAP) in endothelial cells markedly augmented the inflammatory response and cardiovascular dysfunction in a polymicrobial sepsis model induced by cecal ligation and puncture. [Circ Res] Abstract

(Ranked by impact factor of the journal)

Programmed Shape‐Morphing Scaffolds Enabling Facile 3D Endothelialization

Novel shape‐morphing scaffolds enabling programmed deformation from planar shapes to small‐diameter tubular shapes were designed and developed by combining biocompatible shape memory polymer and electrospun nanofibrous membrane. Endothelial cells could be conveniently seeded and attached on the 2D surface of the scaffolds and subsequently self‐rolled into 3D organization at physiological temperature. [Adv Funct Mater] Abstract | Press Release

Role of CD40 and ADAMTS13 in von Willebrand Factor-Mediated Endothelial Cell-Platelet-Monocyte Interaction

It is still elusive how monocytes transmigrate through the endothelial cell (EC) monolayer at atherosclerosis predilection sites. Platelets tethered to ultra-large von Willebrand factor multimers deposited on the luminal EC surface following CD40 ligand stimulation may facilitate monocyte diapedesis. [Proc Natl Acad Sci USA] Abstract

C5b9 Formation on Endothelial Cells Reflects Complement Defects among Patients with Renal Thrombotic Microangiopathy and Severe Hypertension

The authors studied a well defined cohort of 17 patients with hypertension-associated thrombotic microangiopathy to define the prevalence of complement defects by a specific ex vivo serum-based microvascular endothelial cell assay. [J Am Soc Nephrol] Abstract | Graphical Abstract

Endothelial Loss of Fzd5 Stimulates PKC/Ets1-Mediated Transcription of Angpt2 and Flt1

Investigators found that Fzd5 signaling promotes neovessel formation in vitro in a collagen matrix-based 3D co-culture of primary vascular cells. [Angiogenesis] Full Article

A Two-Phase Response of Endothelial Cells to Hydrostatic Pressure

Scientists used a combination of quantitative fluorescence microscopy, atomic force microscopy and molecular perturbations to characterize the specific response of endothelial cells to pressure application. They identified a two-phase response of endothelial cells to acute vs. chronic pressure application. [J Cell Sci] Abstract

In Vivo Antivascular Endothelial Growth Factor Treatment Induces Corneal Endothelium Apoptosis in Rabbits through Changes in p75NTR–proNGF Pathway

Researchers demonstrated that anterior chamber injection, but not intravitreal injection of two different anti‐VEGF agents, aflibercept and ranibizumab, affects rabbit corneal endothelium in terms of survival and apoptosis and is associated with changes in endothelial expression of nerve growth factor precursor (proNGF) and p75 neurotrophin receptor (p75NTR) receptor. [J Cell Physiol] Abstract

miR-503 Suppresses Hypoxia-Induced Proliferation, Migration and Angiogenesis of Endothelial Progenitor Cells by Targeting Apelin

Investigators found that the expression of miR-503 was decreased in mouse bone marrow derived endothelial progenitor cells under the hypoxic condition. [Peptides] Abstract

Pseudopodium-Enriched Atypical Kinase 1 Mediates Angiogenesis by Modulating GATA2-Dependent VEGFR2 Transcription

Researchers provide evidence that PEAK1 plays a central role in orchestrating new vessel formation in vertebrates. Deletion of the PEAK1 gene in zebrafish, mice, and human endothelial cells (ECs) induced severe defects in new blood vessel formation due to deficiencies in EC proliferation, survival, and migration. [Cell Discov] Full Article

Microvascular Endothelial Dysfunction in Rheumatoid Arthritis

Numerous studies have investigated microvascular endothelial dysfunction in rheumatoid arthritis, including its link with disease activity, disease duration and inflammation, the effect of treatments on endothelial function, and possible circulating biomarkers of microvascular endothelial dysfunction. [Nat Rev Rheumatol] Abstract

Vascular Endothelial Dysfunction, a Major Mediator in Diabetic Cardiomyopathy

The authors provide an update on mechanisms that specifically target endothelial dysfunction, which may lead to diabetic cardiomyopathy. [Acta Pharmacol Sin] Abstract

Visit our reviews page to see a complete list of reviews in the endothelial cell research field.

Eisai and Merck Announce Data from Investigational Studies of LENVIMA^® (Lenvatinib) and KEYTRUDA^® (Pembrolizumab) Combination Therapy in Four Different Tumor Types

Eisai Co., Ltd. and Merck & Co., Inc. announced results from presentations of new data and analyses of LENVIMA^®, an orally available kinase inhibitor discovered by Eisai, in combination with Merck & Co., Inc. anti-PD-1 therapy, KEYTRUDA^®, in four different tumor types: unresectable hepatocellular carcinoma, squamous cell carcinoma of the head and neck, advanced renal cell carcinoma, and advanced endometrial carcinoma. [Press release from Eisai Co., Ltd. discussing research presented at the American Society of Clinical Oncology (ASCO), Chicago] Press Release

Arix Bioscience Forms Strategic Collaboration with Evotec AG and Fred Hutchinson Cancer Research Center to Foster New Companies in Cancer and Infectious Diseases

Arix Bioscience plc announced the formation of the LAB591, an academic “BRIDGE” collaboration with the Fred Hutchinson Cancer Research Center and Evotec AG. LAB591 aims to accelerate research discoveries at Fred Hutch and leverage these discoveries to form new companies focused on cancer and infectious disease drug development. [Arix Bioscience plc] Press Release

UT Health San Antonio Receives $24 Million NIH Research Boost

For the third time in ten years, UT Health San Antonio has garnered highly competitive National Institutes of Health (NIH) grants to speed the translation of research discovery into improved patient care. [UT Health San Antonio] Press Release

Europe’s Top Science Funder Shows High-Risk Research Pays Off

A popular and unusual self-review carried out by Europe’s most prestigious science funder is back. The annual assessment, now in its third year, found that nearly one in five projects by the European Research Council led to a scientific breakthrough. [Nature News] Editorial

‘Right-to-Try’ Law Intended to Weaken the FDA, Measure’s Sponsor Says in Blunt Remarks

Sen. Ron Johnson, the author of the federal “right-to-try” law signed by President Trump this week, wants to make one thing clear: His new law is meant to weaken the FDA. “This law intends to diminish the FDA’s power over people’s lives, not increase it,” he wrote in a letter to Commissioner Scott Gottlieb. [STAT News] Editorial

China to Crack Down on Fraud in Scandal-Hit Scientific Research amid ZTE Wrangle

China has issued the first national guidelines to enforce academic integrity in scientific research and vowed to punish academics and institutes for misconduct such as plagiarism and fabrication of data. [South China Morning Post Publishers Ltd] Editorial

Sweden Commits to Open Science with New Open-Access Publishing Deal

Swedish researchers can now publish their articles in Frontiers’ Open Access journals through a simplified process that covers publishing fees, thanks to a national agreement announced between Frontiers and the National Library of Sweden, on behalf of the organizations participating in the Bibsam Consortium. [American Association for the Advancement of Science] Editorial

NEW ComBio 2018
September 23-26, 2018
Sydney, Australia

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Position – Vascular Development (University of Massachusetts)

NEW Postdoctoral Fellow – Stem Cell Biology and Pharmacogenomics (Northwestern University)

NEW Postdoctoral Researcher – Immunotherapy (Memorial Sloan Kettering Cancer Center)

Research Technologist – Endothelial Cell Biology (STEMCELL Technologies Inc.)

Postdoctoral Fellow – Endothelial Cell Biology (Blood Research Institute)

Postdoctoral Position – Angiogenesis and Vessel Malformation (Karolinska Institutet)

Postdoctoral Fellow – Vascular Smooth Muscle and Endothelial Cell Ion Channels (The University of Tennessee)

PhD Positions – Angiogenesis and Vascular Metabolism (VIB)

Postdoctoral Fellows – Endothelial Cell Biology (KU Leuven)

Assistant/Associate/Full Professor – Translational and Vascular Biology (University of Texas Health Science Center)

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