Endothelial Cell News 3.20 June 11, 2018 | |
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TOP STORYSoluble E-Cadherin Promotes Tumor Angiogenesis and Localizes to Exosome Surface Researchers showed that soluble E-cadherin (sE-cad), which is highly expressed in the malignant ascites of ovarian cancer patients, is a potent inducer of angiogenesis. In addition to ectodomain shedding, they provided further evidence that sE-cad is abundantly released in the form of exosomes. [Nat Commun] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)The authors identified novel neuropilin-1 (NRP1) species in endothelial cells and demonstrated that regulation of NRP1 proteolysis via ADAMs 9 and 10 is a new regulatory pathway able to modulate vascular endothelial growth factor (VEGF) angiogenic signaling. [Arterioscler Thromb Vasc Biol] Abstract | Download Full Article Laminin-Dystroglycan Signaling Regulates Retinal Arteriogenesis Scientists provide evidence that Laminin-γ3 is deposited at both arterial and venous basement membranes (BMs) during arteriogenesis. Vascular BM Laminin-γ3 bound dystroglycan, a laminin receptor preferentially expressed by arterial endothelial cells during arteriogenesis. [FASEB J] Abstract Using a model of disturbed flow in mice, researchers found that ZBTB46 is expressed in murine arterial ECs in vivo, and is downregulated by disturbed flow. In vitro results using HAECs showed that cell confluence and laminar shear stress, both known physiological conditions promoting EC quiescence, led to upregulation of ZBTB46 expression. [Lab Invest] Full Article Sex Differences Influencing Micro- and Macrovascular Endothelial Phenotype In Vitro Scientists focused on vascular endothelial cells isolated from aorta and skeletal muscle vessels of age‐matched male and female rats under identical conditions of short term culture. [J Physiol] Abstract With increasing evidence for the importance of vascularization in tumor biology, investigators focused on the isolation and characterization of endothelial cells from primary glioblastomas, low-grade gliomas and meningiomas. [Sci Rep] Full Article The underlying mechanisms of action of endothelial progenitor cell exosomes were examined in vitro endothelial functional assays including the TEER, proliferation, angiogenesis and migration. [Exp Cell Res] Abstract Inhibition of miR-135b by SP-1 Promotes Hypoxia-Induced Vascular Endothelial Cell Injury via HIF-1α To investigate the underlying mechanism of SP-1 on hypoxia induced human umbilical vein endothelial cells injury, the anti-miR-135b or HIF-1α agonist were used. Results indicated that both anti-miR-135b or CoCl2 treatment reversed the effects of SP-1 siRNA under hypoxia. [Exp Cell Res] Abstract Notch1 Regulates Endothelial Apoptosis via ERK Pathway in Chronic Obstructive Pulmonary Disease The authors investigated whether Notch signaling was involved in cigarette smoke induced endothelial apoptosis in COPD. Notch1, 2, 4 were expressed in endothelial cells, whereas, Notch3 was mainly localized in smooth muscle cells. [Am J Physiol Cell Physiol] Abstract | Full Article Researchers showed that endothelial miR-342-3p expression was significantly compromised in type 2 diabetes mellitus (T2DM) organisms and this inhibition powerfully blocked vasculogenesis in vivo by repressing endothelial proliferation and migration. [Biochem Biophys Res Commun] Abstract | |
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REVIEWSLiver Sinusoidal Endothelial Cells — Gatekeepers of Hepatic Immunity The authors outline how liver sinusoidal endothelial cells influence the immune microenvironment within the liver and discuss their contribution to immune-mediated liver diseases and the complications of fibrosis and carcinogenesis. [Nat Rev Gastroenterol Hepatol] Abstract Von Willebrand Factor Regulation of Blood Vessel Formation Researchers review the evidence showing that Von Willebrand Factor (VWF) is involved in blood vessel formation, discuss the role of VWF high molecular weight multimers in regulating angiogenesis, and the value of studies on blood outgrowth endothelial cells in developing a precision medicine approach to validate novel treatments for angiodysplasia in congenital VWD and acquired von Willebrand syndrome. [Blood] Abstract Visit our reviews page to see a complete list of reviews in the endothelial cell research field. | |
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INDUSTRY NEWSDual-Purpose Wound Dressing Supported by $2 Million NIH Grant Development of wound dressings made of semi-synthetic biomaterials will be the focus of a five-year, $2 million grant from the National Institutes of Health’s National Institute of Arthritis and Musculoskeletal and Skin Diseases. Once developed, this new kind of wound dressing would promote faster and more complete healing for the millions of people who suffer from skin wounds. [The Pennsylvania State University] Press Release Researchers to Discuss Science Launching on Next Resupply Mission to Space Station NASA will host a media teleconference to discuss a number of science investigations launching to the International Space Station on the next SpaceX commercial resupply mission. Participating in the briefing will be Paul Jaminet, founder and chief executive officer, and Shou-Ching Jaminet, chief scientist, at Angiex who will discuss Angiex’s investigation of endothelial cells. Culturing endothelial cells in microgravity could create an important model system for evaluating the action of any vascular-targeted drug. [National Aeronautics and Space Administration] Press Release | |
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POLICY NEWSChina Introduces Sweeping Reforms to Crack Down on Academic Misconduct China is getting tough on scientific misconduct. The country’s most powerful bodies, the Chinese Communist Party and the State Council, introduced a raft of reforms on 30 May aimed at improving integrity across the research spectrum, from funding and job applications to peer-review and publications. [Nature News] Editorial More Restrictive U.S. Policy on Chinese Graduate Student Visas Raises Alarm Reversing yet another policy of the previous administration, the U.S. Department of State began applying tougher restrictions on some Chinese graduate students. The new policy shortens from five years to one year the duration of visas for those planning to study aviation, robotics, and advanced manufacturing. [ScienceInsider] Editorial Leading Salk Scientist Resigns after Allegations of Harassment The prominent cancer biologist Inder Verma unconditionally resigned from the Salk Institute for Biological Studies in San Diego, California, June 6, and the research institute’s board of trustees voted unanimously to accept his resignation. [ScienceInsider] Editorial Go for Launch: A Former Astronaut Becomes Spain’s Science Minister Spain has a ministry of science again—and none other than the first Spanish astronaut is leading it. The new transition government led by socialist Pedro Sánchez announced that Pedro Duque, who visited space twice, will be at the helm of the newly created Ministry for Science, Innovation, and Universities. The announcement was cheered by the Spanish scientific community, which has long suffered from declining budgets and bureaucratic hurdles. [ScienceInsider] Editorial EU to World: Join Our €100-Billion Research Program The European Commission has outlined how it plans to spend the biggest research and innovation budget in its history. In a document that sets out plans for its next major science-funding program, the Commission also confirmed new rules that will, for the first time, allow any country in the world — including a post-Brexit United Kingdom — to take part. [Nature News] Editorial
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EVENTSNEW Joint Dutch German Vascular Biology Meeting Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Fellow – Vascular and Endothelial Cell Biology (Augusta University) Research Technologist – Endothelial Cell Biology (STEMCELL Technologies Inc.) Postdoctoral Position – Vascular Development (University of Massachusetts) Postdoctoral Fellow – Stem Cell Biology and Pharmacogenomics (Northwestern University) Postdoctoral Researcher – Immunotherapy (Memorial Sloan Kettering Cancer Center) Postdoctoral Fellow – Endothelial Cell Biology (Blood Research Institute) Postdoctoral Position – Angiogenesis and Vessel Malformation (Karolinska Institutet) PhD Positions – Angiogenesis and Vascular Metabolism (VIB) Postdoctoral Fellows – Endothelial Cell Biology (KU Leuven) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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