Endothelial Cell News 3.21 June 18, 2018 | |
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TOP STORYNEDD9 Targets COL3A1 to Promote Endothelial Fibrosis and Pulmonary Arterial Hypertension Scientists developed and analyzed a fibrosis protein-protein network in silico, which predicted that the SMAD3 target neural precursor cell expressed developmentally down-regulated 9 (NEDD9) is a critical hyperaldosteronism-regulated node underpinning pathogenic vascular fibrosis. [Sci Transl Med] Abstract | Press Release | |
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PUBLICATIONS(Ranked by impact factor of the journal)Modulation of Angiogenic Activity by Light-Activatable miRNA-Loaded Nanocarriers The authors report a plasmonic nanocarrier to control the release of two microRNAs. Using an in vivo acute wound healing animal model, they demonstrated that the order by which each miRNA was released in transplanted outgrowth endothelial cells significantly impacted the wound healing kinetics. [ACS Nano] Abstract | Graphical Abstract Investigators showed that oxidized phospholipids (oxPAPC) induce a gene network regulating serine-glycine metabolism with the mitochondrial methylenetetrahydrofolate dehydrogenase/cyclohydrolase (MTHFD2) as a causal regulator using integrative network modeling and Bayesian network analysis in human aortic endothelial cells. [Nat Commun] Full Article Caspr1 Is a Host Receptor for Meningitis-Causing Escherichia coli Genetic ablation of endothelial Caspr1 and blocking IbeA-Caspr1 interaction effectively prevented E. coli penetration into the brain during meningitis in rodents. IbeA interacted with extracellular domain of Caspr1 to activate focal adhesion kinase signaling causing E. coli internalization into the brain endothelial cells of blood-brain barrier. [Nat Commun] Full Article In vivo, migration toward and adhesion to the ischemic endothelium facilitated the proangiogenic actions of transplanted proangiogenic cells (PACs). In vitro, PAC migration toward SDF-1α/CXCL12 was impaired by anti-miR-210 and enhanced by pre-miR-210. [Mol Ther] Abstract Flavorings in Tobacco Products Induce Endothelial Cell Dysfunction Freshly isolated endothelial cells from participants who use nonmenthol- or menthol-flavored tobacco cigarettes showed impaired A23187-stimulated nitric oxide production compared with endothelial cells from nonsmoking participants. [Arterioscler Thromb Vasc Biol] Abstract | Press Release Given that TLR-4 activation in microvascular endothelial cells triggers a robust inflammatory response, the authors hypothesized that inhibition of TLR-4 signaling prevents endothelial cell death and improves outcomes after stroke. [Mol Neurobiol] Abstract In vitro gain-of-function and loss-of-function studies revealed that ATP-binding cassette transporter G1 (ABCG1)-overexpressing endothelial progenitor cells showed increased migration and tube formation and differentiation via the Lck/Yes-related novel protein tyrosine kinase/Akt/endothelial NO synthase pathway by enhancing cellular cholesterol efflux. [FASEB J] Abstract Gap Junction-Mediated miR-200b on Osteogenesis and Angiogenesis in Coculture between MSCs and HUVECs Rat bone-marrow derived mesenchymal stem cells (BMSCs) formed functional gap junctions composed of connexin 43 with HUVECs, through which miR-200b could transfer from BMSCs to HUVECs to regulate osteogenesis and angiogenesis. As a negative regulator, the decrease in miR-200b level in BMSCs derepressed the expression of VEGF-A, leading to promoted osteogenic differentiation. [J Cell Sci] Abstract The authors investigated the effects of direct current stimulation (DCS) on fluid and solute transport across endothelial cell (EC) monolayers in vitro. DCS induced fluid and solute movement across EC layers that persisted only for the duration of the stimulation suggesting an electroosmosis mechanism. [Sci Rep] Full Article | |
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REVIEWSDevelopment of the Renal Vasculature Researchers provide an overview of the renal vascular anatomy, histology, and current knowledge of the embryological origin and molecular pathways involved in its development. [Semin Cell Dev Biol] Abstract Visit our reviews page to see a complete list of reviews in the endothelial cell research field. | |
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INDUSTRY NEWSNational Cancer Institute Selects ASU to Lead Revolutionary Research in Cancer Arizona State University (ASU) has been awarded more than $8.5 million over five years from the National Cancer Institute to establish the Arizona Cancer and Evolution Center. The grant will establish ASU as the hub of an international network of research scientists who are dedicated to understanding cancer in an entirely new way. [National Cancer Institute] Press Release The Scripps Research Institute and ShangPharma Innovation, Inc. announced a strategic collaboration to accelerate the development of innovative drug candidates through scientific collaboration, a services relationship with Shanghai ChemPartner Co. Ltd., and sponsored research at TSRI and its drug discovery affiliate, California Institute for Biomedical Research. [The Scripps Research Institute] Press Release | |
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POLICY NEWSHouse Bill Gives NIH a 3% Boost in 2019, to $38.3 Billion A draft bill released by a House of Representatives spending panel would give the National Institutes of Health (NIH) in Bethesda, Maryland, a $1.25 billion raise in 2019, to $38.3 billion. That is 3% more than this year’s level and $4.1 billion more than President Donald Trump’s administration had requested. [ScienceInsider] Editorial New Zealand Appoints First Female Chief Scientific Adviser The New Zealand government has appointed biochemist Juliet Gerrard as its next chief scientific adviser — the first woman to hold the position. [Nature News] Editorial
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EVENTSNEW Cell Symposia: Translation of Stem Cells to the Clinic: Challenges and Opportunities Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Position – Cardiovascular Disease and Diabetes (Goethe University) Research Technologist – Endothelial Cell Biology (STEMCELL Technologies Inc.) Postdoctoral Fellow – Vascular and Endothelial Cell Biology (Augusta University) Postdoctoral Position – Vascular Development (University of Massachusetts) Postdoctoral Fellow – Stem Cell Biology and Pharmacogenomics (Northwestern University) Postdoctoral Researcher – Immunotherapy (Memorial Sloan Kettering Cancer Center) Postdoctoral Fellow – Endothelial Cell Biology (Blood Research Institute) PhD Positions – Angiogenesis and Vascular Metabolism (VIB) Postdoctoral Fellows – Endothelial Cell Biology (KU Leuven) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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