Endothelial Cell News 3.22 June 5, 2018 | |
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TOP STORYTherapeutic Targeting of Vascular Remodeling and Right Heart Failure in PAH with HIF-2α Inhibitor Upregulation of HIF-2α and its target genes were observed in lung tissues and isolated pulmonary arterial endothelial cells from idiopathic pulmonary arterial hypertension (PAH) patients and three distinct rodent PAH models. [Am J Respir Crit Care Med] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Stem Cell Factor Is Selectively Secreted by Arterial Endothelial Cells in Bone Marrow Prospective isolation revealed that arterial endothelial cells (AECs) secrete nearly all detectable endothelial cells-derived stem cell factors. Genetic deletion of Scf in AECs, but not sinusoidal endothelial cells, significantly reduced functional hematopoietic stem cells. [Nat Commun] Full Article Targeting β1-Integrin Inhibits Vascular Leakage in Endotoxemia β1-integrin inhibiting antibodies bound to the vascular endothelium in vivo improved the integrity of endothelial cell-cell junctions and protected mice from endotoxemia-associated cardiac failure, without affecting endothelial inflammation, serum proinflammatory cytokine levels, or TIE receptor signaling. [Proc Natl Acad Sci USA] Full Article | Press Release Scientists identified protein disulfide isomerase A1 (PDIA1) as a thiol reductase for the mitochondrial fission protein Drp1. A biotin-labeled Cys-OH trapping probe and rescue experiments revealed that PDIA1 depletion in endothelial cells (ECs) induces sulfenylation of Drp1 at Cys644, promoting mitochondrial fragmentation and ROS elevation without inducing ER stress, which drives EC senescence. [Cell Rep] Abstract | Graphical Abstract Real-Time Observation of Leukocyte-Endothelium Interactions in Tissue-Engineered Blood Vessel Investigators demonstrated that treatment with anti-TNF-α or an NF-kB signaling pathway inhibitor would attenuate the endothelium activation and reduce the number of leukocyte adhesion and transendothelial migration events close to the control. [Lab Chip] Abstract | Graphical Abstract Soluble CD146 increased the number of isolated peripheral blood Endothelial Colony Forming Cells colonies and lowered their onset time. [Sci Rep] Full Article Effect of Calcium Electroporation on Tumor Vasculature Calcium electroporation considerably inhibited cell migratory capabilities of endothelial cells and their potential to form capillary-like structures. [Sci Rep] Full Article The Contribution of EDF1 to PPARγ Transcriptional Activation in VEGF-Treated Human Endothelial Cells Researchers showed that VEGF stimulates the nuclear translocation of endothelial differentiation-related factor 1, a highly conserved intracellular protein implicated in molecular events that are pivotal to endothelial function. [Int J Mol Sci] Full Article HUVECs were exposed to oxygen-glucose deprivation, cell proliferation, migration and apoptosis, in vitro tube formation and expression of PTEN/Akt pathway and angiogenic factors were examined in HUVECs after treatment with PTEN inhibitor bisperoxovanadium at different doses. [Metab Brain Dis] Abstract Subscribe to one of our other 19 science newsletters such as Extracellular Matrix News & Cell Therapy News. | |
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REVIEWSPharmacological Strategies to Inhibit Intra-Plaque Angiogenesis in Atherosclerosis The authors discuss the following potential pharmacological strategies to inhibit intra-plaque angiogenesis: inhibition of vascular endothelial growth factor signaling, inhibition of glycolytic flux, and inhibition of fatty acid oxidation. [Vascul Pharmacol] Abstract Visit our reviews page to see a complete list of reviews in the endothelial cell research field. | |
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INDUSTRY NEWSAphios and LSU Health Shreveport Inventors Granted Patent to Improve Transplantation Aphios Corporation announced that it and the LSU Health Shreveport Department of Molecular & Cellular Physiology have been granted United States Patent No. 9,994,585 entitled “Transplantation Therapies,” for the use of the marine pharmaceutical ‘Bryostatin-1’ as an additive to organ transport and storage solutions. ‘Bryostatin-1’ as a transplant solution additive stabilizes the vascular endothelial compartment against the infiltration of inflammatory leukocytes, especially neutrophils and macrophages in post-transplant liver and kidney which in large part drives graft failure in these and other organs. [Aphios Corporation] Press Release Johnson & Johnson Innovation LLC announced the opening of JLABS @ NYC. The 30,000-square foot facility, located at the New York Genome Center in the heart of SoHo, is a collaboration between Johnson & Johnson Innovation, New York State and the New York Genome Center. [Johnson & Johnson Innovation LLC] Press Release | |
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POLICY NEWSWhite House Proposes a Narrowing of FDA’s Mission — And a New Name The Trump administration has proposed a fundamental change to the mission of the FDA, one that would transfer most of the responsibility for regulating food safety to the Department of Agriculture and rename the FDA the “Federal Drug Administration”. [STAT News] Editorial US–Chinese Trade War Puts Scientists in the Cross Hairs Scientific research in the United States could become collateral damage in the country’s escalating trade dispute with China. Both countries went head-to-head in mid-June over tariffs on a long list of goods that includes lab equipment and reagents. That is likely to increase the cost of scientific research, and the impact could be felt more keenly in US labs. [Nature News] Editorial African Scientists Launch Their Own Preprint A group of open science advocates have launched the first preprint aimed exclusively at African scientists. AfricArxiv seeks to improve the visibility of African science by helping academics share their work quickly, say co-founders Justin Ahinon, and Jo Havemann. [Nature News] Editorial
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EVENTSNEW 2018 Till & McCulloch Meetings (TMM2018) Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Associate – Biomedical Engineering (University of Minnesota) Postdoctoral Position – Cardiovascular Disease and Diabetes (Goethe University) Research Technologist – Endothelial Cell Biology (STEMCELL Technologies Inc.) Postdoctoral Fellow – Vascular and Endothelial Cell Biology (Augusta University) Postdoctoral Position – Vascular Development (University of Massachusetts) Postdoctoral Fellow – Stem Cell Biology and Pharmacogenomics (Northwestern University) Postdoctoral Researcher – Immunotherapy (Memorial Sloan Kettering Cancer Center) Postdoctoral Fellow – Endothelial Cell Biology (Blood Research Institute) PhD Positions – Angiogenesis and Vascular Metabolism (VIB) Postdoctoral Fellows – Endothelial Cell Biology (KU Leuven) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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